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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Iron, Manganese

Enzyme and pathway databases

BioCyciSBOY344609:GI0O-4787-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:SbBS512_E4792
OrganismiShigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Taxonomic identifieri344609 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
Proteomesi
  • UP000001030 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Mannonate dehydratasePRO_1000094225Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB2TYW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000195381.
KOiK01686.
OMAiEGDVDMY.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA. 1 hit.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 2 hits.
TIGRFAMsiTIGR00695. uxuA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2TYW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTWRWYGP NDLVSLADVR QAGATGVVTA LHHIPNGEVW SVEEILKRKA
60 70 80 90 100
IVEDAGLVWS VVESIPIHED IKTHTGNYEQ WIANYQQTLR NLAQCGIRTV
110 120 130 140 150
CYNFMPVLDW TRTDLEYVLP DGSKALRFDQ IEFAAFEMHI LKRPGAEADY
160 170 180 190 200
TEEEIAQAAE RFATMSDEDK ARLTRNIIAG LPGAEEGYTL DQFRKHLELY
210 220 230 240 250
KDIDKAKLRE NFAVFLKAII PVAEEVGVRM AVHPDDPPRP ILGLPRIVST
260 270 280 290 300
IEDMQWMVDT VNSMANGFTM CTGSYGVRAD NDLVDMIKQF GPRIYFTHLR
310 320 330 340 350
STMREDNPKT FHEAAHLNSD VDMYEVVKAI VEEEHRRKAE GKEDLIPMRP
360 370 380 390
DHGHQMLDDL KKKTNPGYSA IGRLKGLAEV RGVELAIQRA FFSR
Length:394
Mass (Da):44,884
Last modified:July 1, 2008 - v1
Checksum:iE89B520744C4F7DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001063 Genomic DNA. Translation: ACD07065.1.
RefSeqiWP_000438558.1. NC_010658.1.

Genome annotation databases

EnsemblBacteriaiACD07065; ACD07065; SbBS512_E4792.
KEGGisbc:SbBS512_E4792.
PATRICi18677095. VBIShiBoy129590_5227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001063 Genomic DNA. Translation: ACD07065.1.
RefSeqiWP_000438558.1. NC_010658.1.

3D structure databases

ProteinModelPortaliB2TYW4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD07065; ACD07065; SbBS512_E4792.
KEGGisbc:SbBS512_E4792.
PATRICi18677095. VBIShiBoy129590_5227.

Phylogenomic databases

HOGENOMiHOG000195381.
KOiK01686.
OMAiEGDVDMY.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciSBOY344609:GI0O-4787-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA. 1 hit.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 2 hits.
TIGRFAMsiTIGR00695. uxuA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUXUA_SHIB3
AccessioniPrimary (citable) accession number: B2TYW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.