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B2TW40 (ARNT_SHIB3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase
EC=2.4.2.43
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferase
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
Undecaprenyl phosphate-alpha-L-Ara4N transferase
Gene names
Name:arnT
Ordered Locus Names:SbBS512_E2633
OrganismShigella boydii serotype 18 (strain CDC 3083-94 / BS512) [Complete proteome] [HAMAP]
Taxonomic identifier344609 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella ›

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides By similarity. HAMAP-Rule MF_01165

Catalytic activity

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate. HAMAP-Rule MF_01165

Pathway

Lipopolysaccharide metabolism; 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis. HAMAP-Rule MF_01165

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01165.

Sequence similarities

Belongs to the glycosyltransferase 83 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase HAMAP-Rule MF_01165
PRO_0000380036

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane111 – 13323Helical; Potential
Transmembrane137 – 15418Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane255 – 27521Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane315 – 33521Helical; Potential
Transmembrane346 – 36621Helical; Potential
Transmembrane382 – 40221Helical; Potential
Transmembrane406 – 42621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B2TW40 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 5A77BDADB66E981C

FASTA55062,548
        10         20         30         40         50         60 
MKSVRYLIGL FAFIACYYLL PISTRLLWQP DETRYAEISR EMLASGDWIV PHLLGLRYFE 

        70         80         90        100        110        120 
KPIAGYWINS IGQWLFGANN FGVRAGVIFA TLLTAALVTW FTLRLWRDKR LALLATVIYL 

       130        140        150        160        170        180 
SLFIVYAIGT YAVLDPFIAF WLVAGMCSFW LAMQAQTWKG KSAGFLLLGI TCGMGVMTKG 

       190        200        210        220        230        240 
FLALAVPVLS VLPWVATQKR WKDLFIYGWL AVISCVLTVL PWGLAIAQRE PDFWHYFFWI 

       250        260        270        280        290        300 
EHIQRFALDD AQHRAPFWYY VPVIIAGSLP WLGLLPGALY TGWKNRKHSA TVYLLSWTIM 

       310        320        330        340        350        360 
PLLFFSVAKG KLPTYILSCF ASLAMLMAHY ALLAAKNNPL ALRINGWINI AFGVTGIIAT 

       370        380        390        400        410        420 
FVVSPWGPMN TPVWQTFESY KVFCAWSIFS LWAFFGWYTL TNVEKTWSFA ALCPLGLALL 

       430        440        450        460        470        480 
VGFSIPDRVM EGKHPQFFVE MTQESLQPSR YILTDSVGVA AGLAWSLQRD DIIMYRQTGE 

       490        500        510        520        530        540 
LKYGLNYPDA KGRFVSGDEF ANWLNQHRQE GIITLVLSVD RDEDINSLAI PPADAIDRQE 

       550 
RLVLIQYRPK

« Hide

References

[1]"Complete sequence of Shigella boydii serotype 18 strain BS512."
Rasko D.A., Rosovitz M., Maurelli A.T., Myers G., Seshadri R., Cer R., Jiang L., Ravel J., Sebastian Y.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CDC 3083-94 / BS512.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001063 Genomic DNA. Translation: ACD10073.1.
RefSeqYP_001881080.1. NC_010658.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING344609.SbBS512_E2633.

Protein family/group databases

CAZyGT83. Glycosyltransferase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD10073; ACD10073; SbBS512_E2633.
GeneID6268944.
KEGGsbc:SbBS512_E2633.
PATRIC18672313. VBIShiBoy129590_2916.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1807.
HOGENOMHOG000273002.
KOK07264.
OMARFAMDDA.
ProtClustDBPRK13279.

Enzyme and pathway databases

BioCycSBOY344609:GI0O-4585-MONOMER.
UniPathwayUPA00037.

Family and domain databases

HAMAPMF_01165. ArnT_transfer.
InterProIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39.
[Graphical view]
PfamPF02366. PMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARNT_SHIB3
AccessionPrimary (citable) accession number: B2TW40
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 1, 2008
Last modified: May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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