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B2TW40

- ARNT_SHIB3

UniProt

B2TW40 - ARNT_SHIB3

Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase

Gene

arnT

Organism
Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

    Catalytic activityi

    4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. mannosyltransferase activity Source: InterPro
    2. transferase activity, transferring pentosyl groups Source: InterPro

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-HAMAP
    2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW
    3. protein O-linked glycosylation Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciSBOY344609:GI0O-2632-MONOMER.
    UniPathwayiUPA00037.

    Protein family/group databases

    CAZyiGT83. Glycosyltransferase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferaseUniRule annotation (EC:2.4.2.43UniRule annotation)
    Alternative name(s):
    4-amino-4-deoxy-L-arabinose lipid A transferaseUniRule annotation
    Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
    Undecaprenyl phosphate-alpha-L-Ara4N transferaseUniRule annotation
    Gene namesi
    Name:arnTUniRule annotation
    Ordered Locus Names:SbBS512_E2633
    OrganismiShigella boydii serotype 18 (strain CDC 3083-94 / BS512)
    Taxonomic identifieri344609 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001030: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferasePRO_0000380036Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi344609.SbBS512_E2633.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalUniRule annotationAdd
    BLAST
    Transmembranei81 – 10121HelicalUniRule annotationAdd
    BLAST
    Transmembranei111 – 13323HelicalUniRule annotationAdd
    BLAST
    Transmembranei137 – 15418HelicalUniRule annotationAdd
    BLAST
    Transmembranei165 – 18521HelicalUniRule annotationAdd
    BLAST
    Transmembranei204 – 22421HelicalUniRule annotationAdd
    BLAST
    Transmembranei255 – 27521HelicalUniRule annotationAdd
    BLAST
    Transmembranei288 – 30821HelicalUniRule annotationAdd
    BLAST
    Transmembranei315 – 33521HelicalUniRule annotationAdd
    BLAST
    Transmembranei346 – 36621HelicalUniRule annotationAdd
    BLAST
    Transmembranei382 – 40221HelicalUniRule annotationAdd
    BLAST
    Transmembranei406 – 42621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 83 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1807.
    HOGENOMiHOG000273002.
    KOiK07264.
    OMAiGNWIAPH.
    OrthoDBiEOG6NKQWN.

    Family and domain databases

    HAMAPiMF_01165. ArnT_transfer.
    InterProiIPR022839. ArnT_tfrase.
    IPR003342. Glyco_trans_39.
    [Graphical view]
    PfamiPF02366. PMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2TW40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSVRYLIGL FAFIACYYLL PISTRLLWQP DETRYAEISR EMLASGDWIV    50
    PHLLGLRYFE KPIAGYWINS IGQWLFGANN FGVRAGVIFA TLLTAALVTW 100
    FTLRLWRDKR LALLATVIYL SLFIVYAIGT YAVLDPFIAF WLVAGMCSFW 150
    LAMQAQTWKG KSAGFLLLGI TCGMGVMTKG FLALAVPVLS VLPWVATQKR 200
    WKDLFIYGWL AVISCVLTVL PWGLAIAQRE PDFWHYFFWI EHIQRFALDD 250
    AQHRAPFWYY VPVIIAGSLP WLGLLPGALY TGWKNRKHSA TVYLLSWTIM 300
    PLLFFSVAKG KLPTYILSCF ASLAMLMAHY ALLAAKNNPL ALRINGWINI 350
    AFGVTGIIAT FVVSPWGPMN TPVWQTFESY KVFCAWSIFS LWAFFGWYTL 400
    TNVEKTWSFA ALCPLGLALL VGFSIPDRVM EGKHPQFFVE MTQESLQPSR 450
    YILTDSVGVA AGLAWSLQRD DIIMYRQTGE LKYGLNYPDA KGRFVSGDEF 500
    ANWLNQHRQE GIITLVLSVD RDEDINSLAI PPADAIDRQE RLVLIQYRPK 550
    Length:550
    Mass (Da):62,548
    Last modified:July 1, 2008 - v1
    Checksum:i5A77BDADB66E981C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001063 Genomic DNA. Translation: ACD10073.1.
    RefSeqiYP_001881080.1. NC_010658.1.

    Genome annotation databases

    EnsemblBacteriaiACD10073; ACD10073; SbBS512_E2633.
    GeneIDi6268944.
    KEGGisbc:SbBS512_E2633.
    PATRICi18672313. VBIShiBoy129590_2916.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001063 Genomic DNA. Translation: ACD10073.1 .
    RefSeqi YP_001881080.1. NC_010658.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 344609.SbBS512_E2633.

    Protein family/group databases

    CAZyi GT83. Glycosyltransferase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD10073 ; ACD10073 ; SbBS512_E2633 .
    GeneIDi 6268944.
    KEGGi sbc:SbBS512_E2633.
    PATRICi 18672313. VBIShiBoy129590_2916.

    Phylogenomic databases

    eggNOGi COG1807.
    HOGENOMi HOG000273002.
    KOi K07264.
    OMAi GNWIAPH.
    OrthoDBi EOG6NKQWN.

    Enzyme and pathway databases

    UniPathwayi UPA00037 .
    BioCyci SBOY344609:GI0O-2632-MONOMER.

    Family and domain databases

    HAMAPi MF_01165. ArnT_transfer.
    InterProi IPR022839. ArnT_tfrase.
    IPR003342. Glyco_trans_39.
    [Graphical view ]
    Pfami PF02366. PMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Shigella boydii serotype 18 strain BS512."
      Rasko D.A., Rosovitz M., Maurelli A.T., Myers G., Seshadri R., Cer R., Jiang L., Ravel J., Sebastian Y.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CDC 3083-94 / BS512.

    Entry informationi

    Entry nameiARNT_SHIB3
    AccessioniPrimary (citable) accession number: B2TW40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3