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Protein

Small heat shock protein IbpB

Gene

ibpB

Organism
Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.UniRule annotation

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Small heat shock protein IbpBUniRule annotation
Alternative name(s):
16 kDa heat shock protein BUniRule annotation
Gene namesi
Name:ibpBUniRule annotation
Ordered Locus Names:SbBS512_E4233
OrganismiShigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Taxonomic identifieri344609 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000001030 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001891141 – 142Small heat shock protein IbpBAdd BLAST142

Interactioni

Subunit structurei

Homodimer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to oligomers at high temperatures or high ionic concentrations. The decrease in size of the multimers is accompanied by an increase in chaperone activity.UniRule annotation

Structurei

3D structure databases

SMRiB2TUT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 137sHSPPROSITE-ProRule annotationAdd BLAST112

Domaini

The N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity.UniRule annotation

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000251750
KOiK04081
OMAiKASDGYP

Family and domain databases

CDDicd06470 ACD_IbpA-B_like, 1 hit
Gene3Di2.60.40.790, 1 hit
HAMAPiMF_02001 HSP20_IbpB, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037913 ACD_IbpA/B
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
IPR022848 HSP20_IbpB
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

B2TUT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNFDLSPLM RQWIGFDKLA NALQNAGEGQ SFPPYNIEKS DDNHYRITLA
60 70 80 90 100
LAGFRQEDLE IQLEGTRLSV KGTPEQPKEE KKWLHQGLMN QPFSLSFTLA
110 120 130 140
ENMEVSGATF VNGLLHIDLI RNEPEPIAAQ RIAISERPAL NS
Length:142
Mass (Da):16,063
Last modified:July 1, 2008 - v1
Checksum:i8669D6B66D510A97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001063 Genomic DNA Translation: ACD07660.1

Genome annotation databases

EnsemblBacteriaiACD07660; ACD07660; SbBS512_E4233
KEGGisbc:SbBS512_E4233

Similar proteinsi

Entry informationi

Entry nameiIBPB_SHIB3
AccessioniPrimary (citable) accession number: B2TUT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health