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B2TUE4

- PNCB_SHIB3

UniProt

B2TUE4 - PNCB_SHIB3

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciSBOY344609:GI0O-2389-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:SbBS512_E2387
OrganismiShigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Taxonomic identifieri344609 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001030: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Nicotinate phosphoribosyltransferasePRO_1000129490Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi344609.SbBS512_E2387.

Structurei

3D structure databases

ProteinModelPortaliB2TUE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

B2TUE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQFASPVLH SLLDTDAYKL HMQQAVFHHY YDVHVAAEFR CRGDDLLGIY
60 70 80 90 100
ADAIREQIQA MQHLRLQDDE YQWLSALPFF KADYLNWLRE FRFNPEQVTV
110 120 130 140 150
SNDNGKLDIR LSGPWREVIL WEVPLLAVIS EMVHRYRSPQ ADVAQALDTL
160 170 180 190 200
ESKLVDFSAL TAGLDMSRFH LMDFGTRRRF SREVQETIVK RLQQESWFVG
210 220 230 240 250
TSNYDLARRL SLTPMGTQAH EWFQAHQQIS PDLANSQRAA LAAWLEEYPD
260 270 280 290 300
QLGIALTDCI TMDAFLRDFG VEFASRYQGL RHDSGDPVEW GEKAIAHYKK
310 320 330 340 350
LGIDPQSKTL VFSDNLDLRK AVELYRHFSS RVQLSFGIGT RLTCDIPQVK
360 370 380 390 400
PLNIVIKLVE CNGKPVAKLS DSPGKTICHD KAFVRALRKA FDLPHIKKAS
Length:400
Mass (Da):45,910
Last modified:July 1, 2008 - v1
Checksum:iBE3367D17E789ABD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001063 Genomic DNA. Translation: ACD09571.1.
RefSeqiYP_001880868.1. NC_010658.1.

Genome annotation databases

EnsemblBacteriaiACD09571; ACD09571; SbBS512_E2387.
GeneIDi6272878.
KEGGisbc:SbBS512_E2387.
PATRICi18671762. VBIShiBoy129590_2643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001063 Genomic DNA. Translation: ACD09571.1 .
RefSeqi YP_001880868.1. NC_010658.1.

3D structure databases

ProteinModelPortali B2TUE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 344609.SbBS512_E2387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD09571 ; ACD09571 ; SbBS512_E2387 .
GeneIDi 6272878.
KEGGi sbc:SbBS512_E2387.
PATRICi 18671762. VBIShiBoy129590_2643.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci SBOY344609:GI0O-2389-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Shigella boydii serotype 18 strain BS512."
    Rasko D.A., Rosovitz M., Maurelli A.T., Myers G., Seshadri R., Cer R., Jiang L., Ravel J., Sebastian Y.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CDC 3083-94 / BS512.

Entry informationi

Entry nameiPNCB_SHIB3
AccessioniPrimary (citable) accession number: B2TUE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3