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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Clostridium botulinum (strain Eklund 17B / Type B)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:CLL_A2443
OrganismiClostridium botulinum (strain Eklund 17B / Type B)
Taxonomic identifieri935198 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001195 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Transmembranei57 – 77HelicalUniRule annotationAdd BLAST21
Transmembranei85 – 105HelicalUniRule annotationAdd BLAST21
Transmembranei121 – 141HelicalUniRule annotationAdd BLAST21
Transmembranei154 – 175HelicalUniRule annotationAdd BLAST22
Transmembranei179 – 199HelicalUniRule annotationAdd BLAST21
Transmembranei201 – 221HelicalUniRule annotationAdd BLAST21
Transmembranei243 – 263HelicalUniRule annotationAdd BLAST21
Transmembranei303 – 323HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000906131 – 324Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST324

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B2TS25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDTIKELLN PTVLSALLMG FAFSMVLGPI FIPMLHKLKF GQNIRTDGPK
60 70 80 90 100
SHLKKSGTPT MGGLIFFISV SVTMLIIEYK PTDEGMIVLY SLIAFGIIGF
110 120 130 140 150
LDDILKIIHR DNLGLRAYQK MILLLLFSIA LAYYGYTNIG TDIIIPFMNS
160 170 180 190 200
KLNLGIFYIP LVVVYYAATT NAVNLTDGID GLASSVTVIV LTFFAIVGFK
210 220 230 240 250
TGHYQVGVFS IALAGALLGF LRYNAFPAKI FMGDTGSLAL GGAIATIALI
260 270 280 290 300
LKMPLFIIIV GGIYVVETLS VIIQVTSFKT TGKRVFKMAP IHHHFEQCGW
310 320
SEVKLVTVFS IITLILCIIG FIAL
Length:324
Mass (Da):35,305
Last modified:July 1, 2008 - v1
Checksum:iA17AF6AEF512311D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001056 Genomic DNA. Translation: ACD23486.1.
RefSeqiWP_012424298.1. NC_018648.1.

Genome annotation databases

EnsemblBacteriaiACD23486; ACD23486; CLL_A2443.
GeneIDi19964816.
KEGGicbk:CLL_A2443.
PATRICifig|935198.13.peg.2403.

Similar proteinsi

Entry informationi

Entry nameiMRAY_CLOBB
AccessioniPrimary (citable) accession number: B2TS25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: August 30, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families