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Protein

Argininosuccinate lyase

Gene

argH

Organism
Clostridium botulinum (strain Eklund 17B / Type B)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:CLL_A3115
OrganismiClostridium botulinum (strain Eklund 17B / Type B)
Taxonomic identifieri935198 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001195 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000890751 – 465Argininosuccinate lyaseAdd BLAST465

Structurei

3D structure databases

ProteinModelPortaliB2TQ24.
SMRiB2TQ24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242744.
KOiK01755.
OMAiSIMPHKK.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 2 hits.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiView protein in InterPro
IPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
PANTHERiPTHR43814. PTHR43814. 1 hit.
PfamiView protein in Pfam
PF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiView protein in PROSITE
PS00163. FUMARATE_LYASES. 1 hit.

Sequencei

Sequence statusi: Complete.

B2TQ24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLWGGRFKK GTDELVNDFN SSINIDSRMY KEDIEGSLAH ATMLGEQNII
60 70 80 90 100
SKEASLKITS GLLEILKRMD NNVINVDLTS EDIHSFVEST LTYYIGEYGK
110 120 130 140 150
MLHTARSRND QVTLDLKLYL KKALVKLRKD ILYLEKVLLE KSKEHISTIM
160 170 180 190 200
PGYTHMQKAQ PITLSHHLLA YAEMFKRDIG RINDAYKRTD SMPLGSGALA
210 220 230 240 250
TSTYPIDRYM VAKDLGFSTI TLNSLDSVSD RDYVIETLSA LSLIMMHLSR
260 270 280 290 300
FSEEIILWCT GEFNFVELDD GYSTGSSIMP QKKNPDVAEL IRGKTGRVYG
310 320 330 340 350
DLITLLTVMK GIPLAYNKDM QEDKEALFDA LDTVTLSLKT FAGMIKTMKV
360 370 380 390 400
NKDNMKKSAA LGFTNATDLA DYLVKKGSYF RDAHGIVGQI VLQCIKDNKM
410 420 430 440 450
IEDLTLAELK EYSPTFEEDV YEAINLYTCV EERKVIGGPS SESVKFQIKE
460
LQEFIHQFKG DEMYD
Length:465
Mass (Da):52,652
Last modified:July 1, 2008 - v1
Checksum:i388B1F8AD417BCBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001056 Genomic DNA. Translation: ACD22821.1.
RefSeqiWP_012423666.1. NC_018648.1.

Genome annotation databases

EnsemblBacteriaiACD22821; ACD22821; CLL_A3115.
GeneIDi19963626.
KEGGicbk:CLL_A3115.
PATRICifig|935198.13.peg.3079.

Similar proteinsi

Entry informationi

Entry nameiARLY_CLOBB
AccessioniPrimary (citable) accession number: B2TQ24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: February 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome