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B2TQ23

- ASSY_CLOBB

UniProt

B2TQ23 - ASSY_CLOBB

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Protein
Argininosuccinate synthase
Gene
argG, CLL_A3114
Organism
Clostridium botulinum (strain Eklund 17B / Type B)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881Citrulline By similarity
Binding sitei93 – 931Citrulline By similarity
Binding sitei118 – 1181ATP; via amide nitrogen By similarity
Binding sitei120 – 1201Aspartate By similarity
Binding sitei124 – 1241Aspartate By similarity
Binding sitei124 – 1241Citrulline By similarity
Binding sitei125 – 1251Aspartate By similarity
Binding sitei128 – 1281Citrulline By similarity
Binding sitei177 – 1771Citrulline By similarity
Binding sitei186 – 1861Citrulline By similarity
Binding sitei263 – 2631Citrulline By similarity
Binding sitei275 – 2751Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT508765:GJ4H-3102-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:CLL_A3114
OrganismiClostridium botulinum (strain Eklund 17B / Type B)
Taxonomic identifieri508765 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001195: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Argininosuccinate synthaseUniRule annotation
PRO_1000089030Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi508765.CLL_A3114.

Structurei

3D structure databases

ProteinModelPortaliB2TQ23.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2TQ23-1 [UniParc]FASTAAdd to Basket

« Hide

MNKLNKVILA YSGGLDTSII IPWLKENYNC EVIAVCGNVG QKDELDGLEE    50
KAIKTGASKL YIEDLTKEFV EDYIFPTIQA GAIYEGKYLL GTSFARPLIG 100
KRLVEIAKAE GADAICHGCT GKGNDQVRFE LAVKAFDPDM KIIAPWRIWD 150
IKSREDEIAY AEARNVPIKI NHETNYSKDK NIWHLSHEGL DLEDPKNEPK 200
YDEILELSNS LEKAPNEPTY ITLTFEKGNA VALNGEKMDA VTLLDELNKI 250
GGKNAIGITD MVENRLVGMK SRGVYETPGG TILYKAHKDL EELCLDKETS 300
HYKEQISLKF ADLVYNGLWF TPLREALSEF IKKTQETVTG EIKLKLYKGN 350
IVNAGMTSPY SLYSEEYATF GEDAVYNQND SAGFITLYGL PTVVKAKMYQ 400
SLKKGTK 407
Length:407
Mass (Da):45,558
Last modified:July 1, 2008 - v1
Checksum:i2A35596CB3602E87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001056 Genomic DNA. Translation: ACD22097.1.
RefSeqiYP_001887300.1. NC_010674.1.

Genome annotation databases

EnsemblBacteriaiACD22097; ACD22097; CLL_A3114.
GeneIDi6293898.
KEGGicbk:CLL_A3114.
PATRICi19399040. VBICloBot123574_3022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001056 Genomic DNA. Translation: ACD22097.1 .
RefSeqi YP_001887300.1. NC_010674.1.

3D structure databases

ProteinModelPortali B2TQ23.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 508765.CLL_A3114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD22097 ; ACD22097 ; CLL_A3114 .
GeneIDi 6293898.
KEGGi cbk:CLL_A3114.
PATRICi 19399040. VBICloBot123574_3022.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci CBOT508765:GJ4H-3102-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Clostridium botulinum strain Eklund."
    Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Eklund 17B / Type B.

Entry informationi

Entry nameiASSY_CLOBB
AccessioniPrimary (citable) accession number: B2TQ23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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