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B2TQ14 (THIM_CLOBB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:CLL_A3105
OrganismClostridium botulinum (strain Eklund 17B / Type B) [Complete proteome] [HAMAP]
Taxonomic identifier508765 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383842

Sites

Binding site481Substrate; via amide nitrogen By similarity
Binding site1241ATP By similarity
Binding site1751ATP By similarity
Binding site2021Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B2TQ14 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 48081706B98733C3

FASTA27829,382
        10         20         30         40         50         60 
MINEILDKVV RLLEEVRAKK PLVHSITNYI TATDCANVIL AVGGSPTMAD YVKEVEEIAS 

        70         80         90        100        110        120 
ISSAVVLNMG VISDGMVESM ILAGKSANKN NVPVIFDPVG AGVANFRNES AEKILSEVKI 

       130        140        150        160        170        180 
DIIRGNISEI KFICGLSSET KGVDASESDM NMGNDKKAIV AQELAKKLNC VVAITGVDDI 

       190        200        210        220        230        240 
ISDGKRNVIL SNGHKMLANV TGTGCMSSAL CGAFAGASND YFIAAICAIL TMGISGEIAY 

       250        260        270 
EKSKGIGMGT FHTSLIDAIS MMNENIIKEK AKVTTINR 

« Hide

References

[1]"Complete sequence of Clostridium botulinum strain Eklund."
Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Eklund 17B / Type B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001056 Genomic DNA. Translation: ACD24375.1.
RefSeqYP_001887291.1. NC_010674.1.

3D structure databases

ProteinModelPortalB2TQ14.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING508765.CLL_A3105.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD24375; ACD24375; CLL_A3105.
GeneID6292590.
KEGGcbk:CLL_A3105.
PATRIC19399022. VBICloBot123574_3013.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMALPLMATH.
OrthoDBEOG628F8M.
ProtClustDBPRK09355.

Enzyme and pathway databases

BioCycCBOT508765:GJ4H-3093-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_CLOBB
AccessionPrimary (citable) accession number: B2TQ14
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 1, 2008
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways