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B2TPW1 (B2TPW1_CLOBB) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative K(+)-stimulated pyrophosphate-energized sodium pump HAMAP-Rule MF_01129
EC=3.6.1.1 HAMAP-Rule MF_01129
Alternative name(s):
Membrane-bound sodium-translocating pyrophosphatase HAMAP-Rule MF_01129
Pyrophosphate-energized inorganic pyrophosphatase HAMAP-Rule MF_01129
Gene names
Name:hppA HAMAP-Rule MF_01129
Ordered Locus Names:CLL_A3052 EMBL ACD24512.1
OrganismClostridium botulinum (strain Eklund 17B / Type B) [Complete proteome] [HAMAP] EMBL ACD24512.1
Taxonomic identifier508765 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium ›

Protein attributes

Sequence length675 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane By similarity. HAMAP-Rule MF_01129

Catalytic activity

Diphosphate + H2O = 2 phosphate. HAMAP-Rule MF_01129

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01129

Enzyme regulation

Requires K+ for maximal activity By similarity. HAMAP-Rule MF_01129

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01129

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01129.

Sequence similarities

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. [View classification] HAMAP-Rule MF_01129

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane1 – 2121Helical; By similarity HAMAP-Rule MF_01129
Transmembrane54 – 7421Helical; By similarity HAMAP-Rule MF_01129
Transmembrane77 – 9721Helical; By similarity HAMAP-Rule MF_01129
Transmembrane126 – 14621Helical; By similarity HAMAP-Rule MF_01129
Transmembrane153 – 17321Helical; By similarity HAMAP-Rule MF_01129
Transmembrane221 – 24121Helical; By similarity HAMAP-Rule MF_01129
Transmembrane247 – 26721Helical; By similarity HAMAP-Rule MF_01129
Transmembrane280 – 30021Helical; By similarity HAMAP-Rule MF_01129
Transmembrane303 – 32321Helical; By similarity HAMAP-Rule MF_01129
Transmembrane365 – 38521Helical; By similarity HAMAP-Rule MF_01129
Transmembrane392 – 41221Helical; By similarity HAMAP-Rule MF_01129
Transmembrane450 – 47021Helical; By similarity HAMAP-Rule MF_01129
Transmembrane487 – 50721Helical; By similarity HAMAP-Rule MF_01129
Transmembrane555 – 57521Helical; By similarity HAMAP-Rule MF_01129
Transmembrane577 – 59721Helical; By similarity HAMAP-Rule MF_01129
Transmembrane650 – 67021Helical; By similarity HAMAP-Rule MF_01129

Sites

Site4501Determinant of potassium dependence By similarity HAMAP-Rule MF_01129

Sequences

Sequence LengthMass (Da)Tools
B2TPW1 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: D98A300F27682602

FASTA67569,724
        10         20         30         40         50         60 
MNLLYVSLIA GFIALIVVIF LAKDILKKSP GNEKMIEISG YIEEGAMAFL RKEYSYLCVF 

        70         80         90        100        110        120 
IVVVAIAILV FLNYKTAIAF VVGALFSIIA GYIGMRIAVK SNVRTAEAAK SGIKEALSVA 

       130        140        150        160        170        180 
FSGGTVMGLC VVGLGIIGLS IFSIVFDLNV EYITGFGLGA SSIALFARVG GGIYTKAADV 

       190        200        210        220        230        240 
GADLVGKVEA GIPEDDPRNP AVIADNVGDN VGDVAGMGAD LFESYVGSII SAITLGAVLV 

       250        260        270        280        290        300 
SSWGKEIVIF PLVLSSIGIL ASLIGIVFVK SYKGDNPQKA LNLGSTISGA IVLVAGFIAC 

       310        320        330        340        350        360 
KYLLGSYKIF LPVIAGLLIG LLIGKITEFY TSADYKSVKF IANESETGPA TNIIAGLSVG 

       370        380        390        400        410        420 
MRSTVVPILL IAVGIIVSFF AIGGAKDTAL GLYGIALSAV GMLSTTAITV AVDAYGPIAD 

       430        440        450        460        470        480 
NAGGIAEMCD LDDSIREITD KLDSVGNTTA AIGKGFAIGS AALTALALFA SYSQIVNLET 

       490        500        510        520        530        540 
INLLNPLTLV GVLIGGMLPF LFAALTMQSV GKAATQMVEE VRRQFKENDG ILKGTQKPDY 

       550        560        570        580        590        600 
SKCVEISTNA ALKEMILPGI LAIAVPLLVG ILLGTEALAG VIGGGVVTGV MLAIMMANAG 

       610        620        630        640        650        660 
GAWDNAKKYI ESGVHGGKGS YAHKAGVVGD TVGDPFKDTS GPSMNILIKL MTIVSVVFAP 

       670 
VILKYGGILI NLFIK

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References

[1]"Complete sequence of Clostridium botulinum strain Eklund."
Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Eklund 17B / Type B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001056 Genomic DNA. Translation: ACD24512.1.
RefSeqYP_001887238.1. NC_010674.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING508765.CLL_A3052.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD24512; ACD24512; CLL_A3052.
GeneID6292085.
KEGGcbk:CLL_A3052.
PATRIC19398918. VBICloBot123574_2961.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3808.
HOGENOMHOG000007098.
KOK15987.
OMAKSPGNEK.
ProtClustDBPRK00733.

Enzyme and pathway databases

BioCycCBOT508765:GJ4H-3040-MONOMER.

Family and domain databases

HAMAPMF_01129. PPase_energized_pump.
InterProIPR004131. PPase-energised_H-pump.
[Graphical view]
PfamPF03030. H_PPase. 1 hit.
[Graphical view]
PIRSFPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsTIGR01104. V_PPase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2TPW1_CLOBB
AccessionPrimary (citable) accession number: B2TPW1
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info