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Protein

Putative K(+)-stimulated pyrophosphate-energized sodium pump

Gene

hppA

Organism
Clostridium botulinum (strain Eklund 17B / Type B)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Requires K+ for maximal activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei450Determinant of potassium dependenceUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processIon transport, Sodium transportUniRule annotation, Transport
LigandMagnesiumUniRule annotation, PotassiumUniRule annotation, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Putative K(+)-stimulated pyrophosphate-energized sodium pumpUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Membrane-bound sodium-translocating pyrophosphataseUniRule annotation
Pyrophosphate-energized inorganic pyrophosphataseUniRule annotation
Short name:
Na(+)-PPaseUniRule annotation
Gene namesi
Name:hppAUniRule annotation
Ordered Locus Names:CLL_A3052Imported
OrganismiClostridium botulinum (strain Eklund 17B / Type B)Imported
Taxonomic identifieri935198 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001195 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei54 – 72HelicalUniRule annotationAdd BLAST19
Transmembranei78 – 99HelicalUniRule annotationAdd BLAST22
Transmembranei119 – 146HelicalUniRule annotationAdd BLAST28
Transmembranei152 – 169HelicalUniRule annotationAdd BLAST18
Transmembranei225 – 243HelicalUniRule annotationAdd BLAST19
Transmembranei249 – 269HelicalUniRule annotationAdd BLAST21
Transmembranei281 – 304HelicalUniRule annotationAdd BLAST24
Transmembranei310 – 330HelicalUniRule annotationAdd BLAST21
Transmembranei365 – 384HelicalUniRule annotationAdd BLAST20
Transmembranei390 – 412HelicalUniRule annotationAdd BLAST23
Transmembranei456 – 475HelicalUniRule annotationAdd BLAST20
Transmembranei487 – 507HelicalUniRule annotationAdd BLAST21
Transmembranei555 – 573HelicalUniRule annotationAdd BLAST19
Transmembranei579 – 599HelicalUniRule annotationAdd BLAST21
Transmembranei646 – 674HelicalUniRule annotationAdd BLAST29

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOGENOMiHOG000007098.
KOiK15987.
OMAiNVMPALY.

Family and domain databases

HAMAPiMF_01129. PPase_energized_pump. 1 hit.
InterProiView protein in InterPro
IPR004131. PPase-energised_H-pump.
PANTHERiPTHR31998. PTHR31998. 1 hit.
PfamiView protein in Pfam
PF03030. H_PPase. 1 hit.
PIRSFiPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsiTIGR01104. V_PPase. 1 hit.

Sequencei

Sequence statusi: Complete.

B2TPW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLYVSLIA GFIALIVVIF LAKDILKKSP GNEKMIEISG YIEEGAMAFL
60 70 80 90 100
RKEYSYLCVF IVVVAIAILV FLNYKTAIAF VVGALFSIIA GYIGMRIAVK
110 120 130 140 150
SNVRTAEAAK SGIKEALSVA FSGGTVMGLC VVGLGIIGLS IFSIVFDLNV
160 170 180 190 200
EYITGFGLGA SSIALFARVG GGIYTKAADV GADLVGKVEA GIPEDDPRNP
210 220 230 240 250
AVIADNVGDN VGDVAGMGAD LFESYVGSII SAITLGAVLV SSWGKEIVIF
260 270 280 290 300
PLVLSSIGIL ASLIGIVFVK SYKGDNPQKA LNLGSTISGA IVLVAGFIAC
310 320 330 340 350
KYLLGSYKIF LPVIAGLLIG LLIGKITEFY TSADYKSVKF IANESETGPA
360 370 380 390 400
TNIIAGLSVG MRSTVVPILL IAVGIIVSFF AIGGAKDTAL GLYGIALSAV
410 420 430 440 450
GMLSTTAITV AVDAYGPIAD NAGGIAEMCD LDDSIREITD KLDSVGNTTA
460 470 480 490 500
AIGKGFAIGS AALTALALFA SYSQIVNLET INLLNPLTLV GVLIGGMLPF
510 520 530 540 550
LFAALTMQSV GKAATQMVEE VRRQFKENDG ILKGTQKPDY SKCVEISTNA
560 570 580 590 600
ALKEMILPGI LAIAVPLLVG ILLGTEALAG VIGGGVVTGV MLAIMMANAG
610 620 630 640 650
GAWDNAKKYI ESGVHGGKGS YAHKAGVVGD TVGDPFKDTS GPSMNILIKL
660 670
MTIVSVVFAP VILKYGGILI NLFIK
Length:675
Mass (Da):69,724
Last modified:July 1, 2008 - v1
Checksum:iD98A300F27682602
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001056 Genomic DNA. Translation: ACD24512.1.
RefSeqiWP_012425260.1. NC_018648.1.

Genome annotation databases

EnsemblBacteriaiACD24512; ACD24512; CLL_A3052.
GeneIDi19965447.
KEGGicbk:CLL_A3052.
PATRICi19398918. VBICloBot123574_2961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001056 Genomic DNA. Translation: ACD24512.1.
RefSeqiWP_012425260.1. NC_018648.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD24512; ACD24512; CLL_A3052.
GeneIDi19965447.
KEGGicbk:CLL_A3052.
PATRICi19398918. VBICloBot123574_2961.

Phylogenomic databases

HOGENOMiHOG000007098.
KOiK15987.
OMAiNVMPALY.

Family and domain databases

HAMAPiMF_01129. PPase_energized_pump. 1 hit.
InterProiView protein in InterPro
IPR004131. PPase-energised_H-pump.
PANTHERiPTHR31998. PTHR31998. 1 hit.
PfamiView protein in Pfam
PF03030. H_PPase. 1 hit.
PIRSFiPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsiTIGR01104. V_PPase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB2TPW1_CLOBB
AccessioniPrimary (citable) accession number: B2TPW1
Secondary accession number(s): U4PC04
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: March 15, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.