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B2TPW1

- B2TPW1_CLOBB

UniProt

B2TPW1 - B2TPW1_CLOBB

Protein

Putative K(+)-stimulated pyrophosphate-energized sodium pump

Gene

hppA

Organism
Clostridium botulinum (strain Eklund 17B / Type B)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane.UniRule annotation

    Catalytic activityi

    Diphosphate + H2O = 2 phosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Enzyme regulationi

    Requires K+ for maximal activity.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei450 – 4501Determinant of potassium dependenceUniRule annotation

    GO - Molecular functioni

    1. hydrogen-translocating pyrophosphatase activity Source: UniProtKB-HAMAP
    2. inorganic diphosphatase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. potassium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. proton transport Source: InterPro
    2. sodium ion transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Ion transport, Sodium transportUniRule annotation, Transport

    Keywords - Ligandi

    MagnesiumUniRule annotation, PotassiumUniRule annotation, Sodium

    Enzyme and pathway databases

    BioCyciCBOT508765:GJ4H-3040-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative K(+)-stimulated pyrophosphate-energized sodium pumpUniRule annotation (EC:3.6.1.1UniRule annotation)
    Alternative name(s):
    Membrane-bound sodium-translocating pyrophosphataseUniRule annotation
    Pyrophosphate-energized inorganic pyrophosphataseUniRule annotation
    Gene namesi
    Name:hppAUniRule annotation
    Ordered Locus Names:CLL_A3052Imported
    ORF Names:CB17B2968Imported
    OrganismiClostridium botulinum (strain Eklund 17B / Type B)Imported
    Taxonomic identifieri935198 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001195: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell membraneUniRule annotation, Membrane

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi508765.CLL_A3052.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121Helical;UniRule annotationAdd
    BLAST
    Transmembranei54 – 7421Helical;UniRule annotationAdd
    BLAST
    Transmembranei77 – 9721Helical;UniRule annotationAdd
    BLAST
    Transmembranei126 – 14621Helical;UniRule annotationAdd
    BLAST
    Transmembranei153 – 17321Helical;UniRule annotationAdd
    BLAST
    Transmembranei221 – 24121Helical;UniRule annotationAdd
    BLAST
    Transmembranei247 – 26721Helical;UniRule annotationAdd
    BLAST
    Transmembranei280 – 30021Helical;UniRule annotationAdd
    BLAST
    Transmembranei303 – 32321Helical;UniRule annotationAdd
    BLAST
    Transmembranei365 – 38521Helical;UniRule annotationAdd
    BLAST
    Transmembranei392 – 41221Helical;UniRule annotationAdd
    BLAST
    Transmembranei450 – 47021Helical;UniRule annotationAdd
    BLAST
    Transmembranei487 – 50721Helical;UniRule annotationAdd
    BLAST
    Transmembranei555 – 57521Helical;UniRule annotationAdd
    BLAST
    Transmembranei577 – 59721Helical;UniRule annotationAdd
    BLAST
    Transmembranei650 – 67021Helical;UniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    eggNOGiCOG3808.
    HOGENOMiHOG000007098.
    KOiK15987.
    OMAiYIESGVH.
    OrthoDBiEOG6TXQSF.

    Family and domain databases

    HAMAPiMF_01129. PPase_energized_pump.
    InterProiIPR004131. PPase-energised_H-pump.
    [Graphical view]
    PfamiPF03030. H_PPase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001265. H+-PPase. 1 hit.
    TIGRFAMsiTIGR01104. V_PPase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2TPW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLLYVSLIA GFIALIVVIF LAKDILKKSP GNEKMIEISG YIEEGAMAFL    50
    RKEYSYLCVF IVVVAIAILV FLNYKTAIAF VVGALFSIIA GYIGMRIAVK 100
    SNVRTAEAAK SGIKEALSVA FSGGTVMGLC VVGLGIIGLS IFSIVFDLNV 150
    EYITGFGLGA SSIALFARVG GGIYTKAADV GADLVGKVEA GIPEDDPRNP 200
    AVIADNVGDN VGDVAGMGAD LFESYVGSII SAITLGAVLV SSWGKEIVIF 250
    PLVLSSIGIL ASLIGIVFVK SYKGDNPQKA LNLGSTISGA IVLVAGFIAC 300
    KYLLGSYKIF LPVIAGLLIG LLIGKITEFY TSADYKSVKF IANESETGPA 350
    TNIIAGLSVG MRSTVVPILL IAVGIIVSFF AIGGAKDTAL GLYGIALSAV 400
    GMLSTTAITV AVDAYGPIAD NAGGIAEMCD LDDSIREITD KLDSVGNTTA 450
    AIGKGFAIGS AALTALALFA SYSQIVNLET INLLNPLTLV GVLIGGMLPF 500
    LFAALTMQSV GKAATQMVEE VRRQFKENDG ILKGTQKPDY SKCVEISTNA 550
    ALKEMILPGI LAIAVPLLVG ILLGTEALAG VIGGGVVTGV MLAIMMANAG 600
    GAWDNAKKYI ESGVHGGKGS YAHKAGVVGD TVGDPFKDTS GPSMNILIKL 650
    MTIVSVVFAP VILKYGGILI NLFIK 675
    Length:675
    Mass (Da):69,724
    Last modified:July 1, 2008 - v1
    Checksum:iD98A300F27682602
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001056 Genomic DNA. Translation: ACD24512.1.
    FR745875 Genomic DNA. Translation: CDH91957.1.
    RefSeqiYP_001887238.1. NC_010674.1.

    Genome annotation databases

    EnsemblBacteriaiACD24512; ACD24512; CLL_A3052.
    GeneIDi6292085.
    KEGGicbk:CLL_A3052.
    PATRICi19398918. VBICloBot123574_2961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001056 Genomic DNA. Translation: ACD24512.1 .
    FR745875 Genomic DNA. Translation: CDH91957.1 .
    RefSeqi YP_001887238.1. NC_010674.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 508765.CLL_A3052.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD24512 ; ACD24512 ; CLL_A3052 .
    GeneIDi 6292085.
    KEGGi cbk:CLL_A3052.
    PATRICi 19398918. VBICloBot123574_2961.

    Phylogenomic databases

    eggNOGi COG3808.
    HOGENOMi HOG000007098.
    KOi K15987.
    OMAi YIESGVH.
    OrthoDBi EOG6TXQSF.

    Enzyme and pathway databases

    BioCyci CBOT508765:GJ4H-3040-MONOMER.

    Family and domain databases

    HAMAPi MF_01129. PPase_energized_pump.
    InterProi IPR004131. PPase-energised_H-pump.
    [Graphical view ]
    Pfami PF03030. H_PPase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001265. H+-PPase. 1 hit.
    TIGRFAMsi TIGR01104. V_PPase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Clostridium botulinum strain Eklund."
      Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Eklund 17B / Type BImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Eklund 17BImported.
    3. Shrivastava S., Brinkac L.M., Dodson R.J., Harkins D.M., Durkin A.S., Sutton G.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Eklund 17BImported.
    4. "Genomic and physiological variability within Group II (non-proteolytic) Clostridium botulinum."
      Stringer S.C., Carter A.T., Webb M.D., Wachnicka E., Crossman L.C., Sebaihia M., Peck M.W.
      BMC Genomics 14:333-333(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B str. Eklund 17BImported.

    Entry informationi

    Entry nameiB2TPW1_CLOBB
    AccessioniPrimary (citable) accession number: B2TPW1
    Secondary accession number(s): U4PC04
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3