B2TNG3 (PYRB_CLOBB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	CLL_A2581

Organism

Clostridium botulinum (strain Eklund 17B / Type B) [Complete proteome] [HAMAP]

Taxonomic identifier

508765 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium botulinum › Clostridium botulinum B

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP-Rule MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP-Rule MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' UMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway 'de novo' pyrimidine nucleobase biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Aspartate carbamoyltransferase HAMAP-Rule MF_00001		PRO_1000088750

Sequences

	Sequence		Length	Mass (Da)
	B2TNG3 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 373E089ACECEF97E	FASTA	307	35,157
	10 20 30 40 50 60 MIKDKHLIDP MDFTVEELEE IFKLAHEIIL DPEKFSHVCE GKILGTLFYE PSTRTRFSFE 70 80 90 100 110 120 AAMMRLGGKI LGFSEPNSSS ASKGESLSDT IKMVSIYTDI IAMRHPKEGS AKVASLYSSV 130 140 150 160 170 180 PIINAGDGGH QHPTQTLTDL LTIEMLKDGL SNHTIGICGD LKYGRTVHSL IKAMSRYKGN 190 200 210 220 230 240 KFLLISPKEL RIPDYIREEI LRKNNIEFLE VETLEEVIDK VDILYMTRIQ KERFFNEEEY 250 260 270 280 290 300 LRLRDSYILN KEKMNLAKSD MIVMHPLPRV NEIACEVDYD KRAAYFKQAE YGMYARMALM AKLLGVL

References

[1]

"Complete sequence of Clostridium botulinum strain Eklund." Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Eklund 17B / Type B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001056 Genomic DNA. Translation: ACD24851.1.
RefSeq	YP_001886770.1. NC_010674.1.
3D structure databases
ProteinModelPortal	B2TNG3.
ModBase	Search...
Protein-protein interaction databases
STRING	508765.CLL_A2581.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACD24851; ACD24851; CLL_A2581.
GeneID	6295109.
KEGG	cbk:CLL_A2581.
PATRIC	19397980. VBICloBot123574_2495.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HOG000022685.
KO	K00609.
OMA	YGVPVRM.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	CBOT508765:GJ4H-2570-MONOMER.
UniPathway	UPA00070; UER00116.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr.
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR002082. Asp_carbamoyltransf. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_CLOBB

Accession

Primary (citable) accession number: B2TNG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 1, 2008
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program