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B2TNG3

- PYRB_CLOBB

UniProt

B2TNG3 - PYRB_CLOBB

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Protein

Aspartate carbamoyltransferase

Gene
pyrB, CLL_A2581
Organism
Clostridium botulinum (strain Eklund 17B / Type B)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. aspartate carbamoyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  3. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCBOT508765:GJ4H-2570-MONOMER.
UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferase (EC:2.1.3.2)
Alternative name(s):
Aspartate transcarbamylase
Short name:
ATCase
Gene namesi
Name:pyrB
Ordered Locus Names:CLL_A2581
OrganismiClostridium botulinum (strain Eklund 17B / Type B)
Taxonomic identifieri508765 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001195: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Aspartate carbamoyltransferaseUniRule annotationPRO_1000088750Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi508765.CLL_A2581.

Structurei

3D structure databases

ProteinModelPortaliB2TNG3.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.

Phylogenomic databases

eggNOGiCOG0540.
HOGENOMiHOG000022685.
KOiK00609.
OMAiFDQYGKY.
OrthoDBiEOG61KBJZ.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2TNG3-1 [UniParc]FASTAAdd to Basket

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MIKDKHLIDP MDFTVEELEE IFKLAHEIIL DPEKFSHVCE GKILGTLFYE    50
PSTRTRFSFE AAMMRLGGKI LGFSEPNSSS ASKGESLSDT IKMVSIYTDI 100
IAMRHPKEGS AKVASLYSSV PIINAGDGGH QHPTQTLTDL LTIEMLKDGL 150
SNHTIGICGD LKYGRTVHSL IKAMSRYKGN KFLLISPKEL RIPDYIREEI 200
LRKNNIEFLE VETLEEVIDK VDILYMTRIQ KERFFNEEEY LRLRDSYILN 250
KEKMNLAKSD MIVMHPLPRV NEIACEVDYD KRAAYFKQAE YGMYARMALM 300
AKLLGVL 307
Length:307
Mass (Da):35,157
Last modified:July 1, 2008 - v1
Checksum:i373E089ACECEF97E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001056 Genomic DNA. Translation: ACD24851.1.
RefSeqiWP_012425577.1. NC_010674.1.
YP_001886770.1. NC_010674.1.

Genome annotation databases

EnsemblBacteriaiACD24851; ACD24851; CLL_A2581.
GeneIDi6295109.
KEGGicbk:CLL_A2581.
PATRICi19397980. VBICloBot123574_2495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001056 Genomic DNA. Translation: ACD24851.1 .
RefSeqi WP_012425577.1. NC_010674.1.
YP_001886770.1. NC_010674.1.

3D structure databases

ProteinModelPortali B2TNG3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 508765.CLL_A2581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD24851 ; ACD24851 ; CLL_A2581 .
GeneIDi 6295109.
KEGGi cbk:CLL_A2581.
PATRICi 19397980. VBICloBot123574_2495.

Phylogenomic databases

eggNOGi COG0540.
HOGENOMi HOG000022685.
KOi K00609.
OMAi FDQYGKY.
OrthoDBi EOG61KBJZ.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00116 .
BioCyci CBOT508765:GJ4H-2570-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1370. 2 hits.
HAMAPi MF_00001. Asp_carb_tr.
InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view ]
Pfami PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view ]
PRINTSi PR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMi SSF53671. SSF53671. 1 hit.
TIGRFAMsi TIGR00670. asp_carb_tr. 1 hit.
PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Clostridium botulinum strain Eklund."
    Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Eklund 17B / Type B.

Entry informationi

Entry nameiPYRB_CLOBB
AccessioniPrimary (citable) accession number: B2TNG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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