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B2TNG3 (PYRB_CLOBB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aspartate carbamoyltransferase

EC=2.1.3.2
Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase
Gene names
Name:pyrB
Ordered Locus Names:CLL_A2581
OrganismClostridium botulinum (strain Eklund 17B / Type B) [Complete proteome] [HAMAP]
Taxonomic identifier508765 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP-Rule MF_00001

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP-Rule MF_00001

Sequence similarities

Belongs to the ATCase/OTCase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Aspartate carbamoyltransferase HAMAP-Rule MF_00001
PRO_1000088750

Sequences

Sequence LengthMass (Da)Tools
B2TNG3 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 373E089ACECEF97E

FASTA30735,157
        10         20         30         40         50         60 
MIKDKHLIDP MDFTVEELEE IFKLAHEIIL DPEKFSHVCE GKILGTLFYE PSTRTRFSFE 

        70         80         90        100        110        120 
AAMMRLGGKI LGFSEPNSSS ASKGESLSDT IKMVSIYTDI IAMRHPKEGS AKVASLYSSV 

       130        140        150        160        170        180 
PIINAGDGGH QHPTQTLTDL LTIEMLKDGL SNHTIGICGD LKYGRTVHSL IKAMSRYKGN 

       190        200        210        220        230        240 
KFLLISPKEL RIPDYIREEI LRKNNIEFLE VETLEEVIDK VDILYMTRIQ KERFFNEEEY 

       250        260        270        280        290        300 
LRLRDSYILN KEKMNLAKSD MIVMHPLPRV NEIACEVDYD KRAAYFKQAE YGMYARMALM 


AKLLGVL 

« Hide

References

[1]"Complete sequence of Clostridium botulinum strain Eklund."
Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Eklund 17B / Type B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001056 Genomic DNA. Translation: ACD24851.1.
RefSeqYP_001886770.1. NC_010674.1.

3D structure databases

ProteinModelPortalB2TNG3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING508765.CLL_A2581.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD24851; ACD24851; CLL_A2581.
GeneID6295109.
KEGGcbk:CLL_A2581.
PATRIC19397980. VBICloBot123574_2495.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0540.
HOGENOMHOG000022685.
KOK00609.
OMAFDQYGKY.
OrthoDBEOG61KBJZ.

Enzyme and pathway databases

BioCycCBOT508765:GJ4H-2570-MONOMER.
UniPathwayUPA00070; UER00116.

Family and domain databases

Gene3D3.40.50.1370. 2 hits.
HAMAPMF_00001. Asp_carb_tr.
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMSSF53671. SSF53671. 1 hit.
TIGRFAMsTIGR00670. asp_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRB_CLOBB
AccessionPrimary (citable) accession number: B2TNG3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways