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B2TNG3

- PYRB_CLOBB

UniProt

B2TNG3 - PYRB_CLOBB

Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Clostridium botulinum (strain Eklund 17B / Type B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. aspartate carbamoyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
    3. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciCBOT508765:GJ4H-2570-MONOMER.
    UniPathwayiUPA00070; UER00116.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
    Alternative name(s):
    Aspartate transcarbamylaseUniRule annotation
    Short name:
    ATCaseUniRule annotation
    Gene namesi
    Name:pyrBUniRule annotation
    Ordered Locus Names:CLL_A2581
    OrganismiClostridium botulinum (strain Eklund 17B / Type B)
    Taxonomic identifieri935198 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001195: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Aspartate carbamoyltransferasePRO_1000088750Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi508765.CLL_A2581.

    Structurei

    3D structure databases

    ProteinModelPortaliB2TNG3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATCase/OTCase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0540.
    HOGENOMiHOG000022685.
    KOiK00609.
    OMAiFDQYGKY.
    OrthoDBiEOG61KBJZ.

    Family and domain databases

    Gene3Di3.40.50.1370. 2 hits.
    HAMAPiMF_00001. Asp_carb_tr.
    InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR002082. Asp_carbamoyltransf.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    [Graphical view]
    PfamiPF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view]
    PRINTSiPR00100. AOTCASE.
    PR00101. ATCASE.
    SUPFAMiSSF53671. SSF53671. 1 hit.
    TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
    PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2TNG3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKDKHLIDP MDFTVEELEE IFKLAHEIIL DPEKFSHVCE GKILGTLFYE    50
    PSTRTRFSFE AAMMRLGGKI LGFSEPNSSS ASKGESLSDT IKMVSIYTDI 100
    IAMRHPKEGS AKVASLYSSV PIINAGDGGH QHPTQTLTDL LTIEMLKDGL 150
    SNHTIGICGD LKYGRTVHSL IKAMSRYKGN KFLLISPKEL RIPDYIREEI 200
    LRKNNIEFLE VETLEEVIDK VDILYMTRIQ KERFFNEEEY LRLRDSYILN 250
    KEKMNLAKSD MIVMHPLPRV NEIACEVDYD KRAAYFKQAE YGMYARMALM 300
    AKLLGVL 307
    Length:307
    Mass (Da):35,157
    Last modified:July 1, 2008 - v1
    Checksum:i373E089ACECEF97E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001056 Genomic DNA. Translation: ACD24851.1.
    RefSeqiWP_012425577.1. NC_010674.1.
    YP_001886770.1. NC_010674.1.

    Genome annotation databases

    EnsemblBacteriaiACD24851; ACD24851; CLL_A2581.
    GeneIDi6295109.
    KEGGicbk:CLL_A2581.
    PATRICi19397980. VBICloBot123574_2495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001056 Genomic DNA. Translation: ACD24851.1 .
    RefSeqi WP_012425577.1. NC_010674.1.
    YP_001886770.1. NC_010674.1.

    3D structure databases

    ProteinModelPortali B2TNG3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 508765.CLL_A2581.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD24851 ; ACD24851 ; CLL_A2581 .
    GeneIDi 6295109.
    KEGGi cbk:CLL_A2581.
    PATRICi 19397980. VBICloBot123574_2495.

    Phylogenomic databases

    eggNOGi COG0540.
    HOGENOMi HOG000022685.
    KOi K00609.
    OMAi FDQYGKY.
    OrthoDBi EOG61KBJZ.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00116 .
    BioCyci CBOT508765:GJ4H-2570-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1370. 2 hits.
    HAMAPi MF_00001. Asp_carb_tr.
    InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR002082. Asp_carbamoyltransf.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    [Graphical view ]
    Pfami PF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00100. AOTCASE.
    PR00101. ATCASE.
    SUPFAMi SSF53671. SSF53671. 1 hit.
    TIGRFAMsi TIGR00670. asp_carb_tr. 1 hit.
    PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Clostridium botulinum strain Eklund."
      Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Eklund 17B / Type B.

    Entry informationi

    Entry nameiPYRB_CLOBB
    AccessioniPrimary (citable) accession number: B2TNG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3