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B2TLZ7 (DNAK_CLOBB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene names
Name:dnaK
Ordered Locus Names:CLL_A0891
OrganismClostridium botulinum (strain Eklund 17B / Type B) [Complete proteome] [HAMAP]
Taxonomic identifier508765 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length616 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a chaperone By similarity. HAMAP MF_00332

Induction

By stress conditions e.g. heat shock By similarity. HAMAP MF_00332

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Biological processStress response
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein folding

Inferred from electronic annotation. Source: InterPro

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

unfolded protein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 616616Chaperone protein DnaK HAMAP MF_00332
PRO_1000119689

Amino acid modifications

Modified residue1751Phosphothreonine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
B2TLZ7 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: B522699D34792E75

FASTA61665,842
        10         20         30         40         50         60 
MGKIIGIDLG TTNSCVAVME GGEPVVITNS EGARTTPSVV SFQADGERLV GQVAKRQSIT 

        70         80         90        100        110        120 
NPDKTIISIK RHMGTSYKVD IDGKNYSPQE ISAMVLQKIK ADAESYLGES VTQAVITVPA 

       130        140        150        160        170        180 
YFNDSERQAT KDAGKIAGLE VLRIINEPTA AALAYGLDKM DSNHKILVYD LGGGTFDVSI 

       190        200        210        220        230        240 
LELGDGVFEV LSTNGDTKLG GDDFDQKVMD YIAETFKAEN GIDLRQDKMA LQRLKEAAEK 

       250        260        270        280        290        300 
AKIELSSSMQ TNINLPFITA DATGPKHIDL NLTRAKFNEI TNDLVQRSIE PMKKALSDAA 

       310        320        330        340        350        360 
ISIDEIEKII LVGGSTRIPA VVEAVKNFTG KDPSKGVNPD ECVAVGAAVQ AGVLTGEVKD 

       370        380        390        400        410        420 
VLLLDVTPLT LGIETAGGIA TPLIERNTTI PTKKSQIFST AADSQTSVEI NVVQGERQMA 

       430        440        450        460        470        480 
MDNKSLGRFT LSGIAPAPRG IPQIEVTFDI DANGIVKVSA LDKGTGKEAN ITITASTNLN 

       490        500        510        520        530        540 
DDEIDKAVKE AEKFAEEDKK RKEKVETLNN ADQLIYQTEK ALTELGDKVS AEDKAKVTEK 

       550        560        570        580        590        600 
LEALKAIKDG EDLEAIKKAT EELTQEFYAV SSKVYAAAGG DPSQAGGFDP NAAGGAQQEP 

       610 
HDDNVVDADF KVDDDK

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References

[1]"Complete sequence of Clostridium botulinum strain Eklund."
Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Eklund 17B / Type B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001056 Genomic DNA. Translation: ACD22007.1.
RefSeqYP_001885092.1. NC_010674.1.

3D structure databases

ProteinModelPortalB2TLZ7.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2TLZ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6293073.
GenomeReviewsGene locus CLL_A0891 in contig CP001056_GR.
KEGGcbk:CLL_A0891.
PATRIC19394629. VBICloBot123574_0826.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG334976.
OMAMQTNINL.
ProtClustDBPRK00290.

Family and domain databases

HAMAPMF_00332. DnaK.
[Tree]
InterProIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR001023. Hsp70.
IPR013126. Hsp_70.
[Graphical view]
KOK04043.
PANTHERPTHR19375. Hsp70. 1 hit.
PfamPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
TIGRFAMsTIGR02350. Prok_dnaK. 1 hit.
PROSITEPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNAK_CLOBB
AccessionPrimary (citable) accession number: B2TLZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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