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Protein

Anti-sigma F factor

Gene

spoIIAB

Organism
Clostridium botulinum (strain Eklund 17B / Type B)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Sporulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT508765:GJ4H-869-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-sigma F factorUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Stage II sporulation protein ABUniRule annotation
Gene namesi
Name:spoIIABUniRule annotation
Ordered Locus Names:CLL_A0875
OrganismiClostridium botulinum (strain Eklund 17B / Type B)
Taxonomic identifieri935198 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001195 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Anti-sigma F factorPRO_1000130809Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000269931.
KOiK06379.
OMAiHAYEDKI.
OrthoDBiEOG6S7XW5.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00637. Anti_sigma_F.
InterProiIPR010194. Anti-sigma_F.
IPR003594. HATPase_C.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01925. spIIAB. 1 hit.

Sequencei

Sequence statusi: Complete.

B2TLY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYENKMNLEF VSKSQNEAFA RVAVAAFIAQ LDPTIDEISD VKTAVSEAVT
60 70 80 90 100
NSIIHGYENK EDGVIKIEVE ICDGEVTIEI TDNGKGIEDI PKVMEPLYTS
110 120 130 140
RPDLERSGMG FTVMETFMDG LLVESEKEKG TRVRMKKKFN ILS
Length:143
Mass (Da):15,999
Last modified:July 1, 2008 - v1
Checksum:iC71467886F5BC559
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001056 Genomic DNA. Translation: ACD24377.1.
RefSeqiWP_012425133.1. NC_010674.1.

Genome annotation databases

EnsemblBacteriaiACD24377; ACD24377; CLL_A0875.
GeneIDi19964144.
KEGGicbk:CLL_A0875.
PATRICi19394597. VBICloBot123574_0810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001056 Genomic DNA. Translation: ACD24377.1.
RefSeqiWP_012425133.1. NC_010674.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD24377; ACD24377; CLL_A0875.
GeneIDi19964144.
KEGGicbk:CLL_A0875.
PATRICi19394597. VBICloBot123574_0810.

Phylogenomic databases

HOGENOMiHOG000269931.
KOiK06379.
OMAiHAYEDKI.
OrthoDBiEOG6S7XW5.

Enzyme and pathway databases

BioCyciCBOT508765:GJ4H-869-MONOMER.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00637. Anti_sigma_F.
InterProiIPR010194. Anti-sigma_F.
IPR003594. HATPase_C.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01925. spIIAB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Clostridium botulinum strain Eklund."
    Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Eklund 17B / Type B.

Entry informationi

Entry nameiSP2AB_CLOBB
AccessioniPrimary (citable) accession number: B2TLY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: November 11, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.