Reviewed, UniProtKB/Swiss-Prot B2TL86 (DEOC_CLOBB)

Names and origin

Protein names

Recommended name:
    Deoxyribose-phosphate aldolase
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase
      Short name=Deoxyriboaldolase
      Short name=DERA

Gene names

Name:	deoC
Ordered Locus Names:	CLL_A0734

Organism

Clostridium botulinum (strain Eklund 17B / Type B) [Complete proteome] [HAMAP]

Taxonomic identifier

508765 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_1000094840
Sites
	Active site	153	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	182	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2TL86-1 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 2E2E81666177253C	FASTA	221	23,999
	10 20 30 40 50 60 MNNAEILKHV DHTLLKPVAT WDDIKKICDE SIEYNTASIC IPACYISRIH ATYGDKVNIC 70 80 90 100 110 120 TVVGFPLGYS STEGKIAETK QALADGANEI DMVINISDVK NKAYDKVTEE IRALKEVVGN 130 140 150 160 170 180 KILKVIIETC YLTEEEKIAM CKAVTEAGAD YIKTSTGFGT GGATLEDIKL FKKHIGPNVK 190 200 210 220 IKAAGGVSTV EDLNMFINEG CDRLGTSRAV GLLKGEETQG Y

References

[1]	"Complete sequence of Clostridium botulinum strain Eklund." Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001056 Genomic DNA. Translation: ACD22952.1.
RefSeq	YP_001884935.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6293808.
GenomeReviews	Gene locus CLL_A0734 in contig CP001056_GR.
KEGG	cbk:CLL_A0734.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EEKIAMC.
Family and domain databases
HAMAP	MF_00114. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_CLOBB

Accession

Primary (citable) accession number: B2TL86

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 1, 2008
Last modified:	November 3, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)