Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alanine racemase

Gene

alr

Organism
Clostridium botulinum (strain Eklund 17B / Type B)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Active sitei267Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei315Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CLL_A1573Imported
OrganismiClostridium botulinum (strain Eklund 17B / Type B)Imported
Taxonomic identifieri935198 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001195 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliB2TKD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini246 – 374Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiWRGPILL.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

B2TKD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIMRPVWA EIDLDAIAYN MRNIKKLAQN KDVIAVVKAD CYGHGALDVV
60 70 80 90 100
PTLLENGASR LAVAVLTEAI ELRNNNITAP IMILGYTPEY LFEEVVNYDI
110 120 130 140 150
EQTVYDLEYA KKLSHLAIKF NKKAKVHIAI DTGMGRIGFI PNEKAIKDIK
160 170 180 190 200
KIYNLKGLDV IGIFTHFSTS DETDKEYTNE QFNKFTSFID MLSKVGVKIP
210 220 230 240 250
IKHISNSGAI IDMPKTYLDS VRAGIILYGY YPSDEINKDN IKLKPALTLK
260 270 280 290 300
ASLTRVQELD INSYISYGKT FKTERKSIIA TLPIGYADGY SRLLAPGAKV
310 320 330 340 350
IINGKFSPII GRICMDQCMI DVTDIDDIHV GDEVIILGED GNLKLTANDL
360 370 380
AKSMGTINYE ILCMLKYRIP RVYMKNGKIF TVRNYL
Length:386
Mass (Da):43,373
Last modified:July 1, 2008 - v1
Checksum:i1B36636BDEEB26D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001056 Genomic DNA. Translation: ACD22809.1.
RefSeqiWP_012423654.1. NC_018648.1.

Genome annotation databases

EnsemblBacteriaiACD22809; ACD22809; CLL_A1573.
GeneIDi19965073.
KEGGicbk:CLL_A1573.
PATRICifig|935198.13.peg.1519.

Similar proteinsi

Entry informationi

Entry nameiB2TKD2_CLOBB
AccessioniPrimary (citable) accession number: B2TKD2
Secondary accession number(s): U4PFB0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 27, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported