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B2TJ78 (IOLC_CLOBB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-dehydro-2-deoxygluconokinase
EC=2.7.1.92
Alternative name(s):
2-deoxy-5-keto-D-gluconate kinase
Short name=DKG kinase
Gene names
Name:iolC
Ordered Locus Names:CLL_A1302
OrganismClostridium botulinum (strain Eklund 17B / Type B) [Complete proteome] [HAMAP]
Taxonomic identifier508765 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium ›

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP) By similarity. HAMAP-Rule MF_01668

Catalytic activity

ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate. HAMAP-Rule MF_01668

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 5/7. HAMAP-Rule MF_01668

Sequence similarities

Belongs to the carbohydrate kinase PfkB family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processinositol catabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular_function5-dehydro-2-deoxygluconokinase activity

Inferred from electronic annotation. Source: HAMAP

ATP binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3393395-dehydro-2-deoxygluconokinase HAMAP-Rule MF_01668
PRO_0000352295

Sequences

Sequence LengthMass (Da)Tools
B2TJ78 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 0F9365A205506B7D

FASTA33937,895
        10         20         30         40         50         60 
MGYIKFQKDR KFEIVPIGRV AIDFNPIDIN RPLSESKTFK KYLGGSPANI AVGLSRLGKK 

        70         80         90        100        110        120 
VGFIGKVSKD QFGKFVVDYF DNEGIDTSQI KYAENGESLG LTFTEIASPT ESSILMYRNG 

       130        140        150        160        170        180 
IADLELDVNE IDEEYIKNTK AIVISGTALA KSPSREAALK ALELAKKNDT IVIFDVDYRE 

       190        200        210        220        230        240 
YNWKNKDEIA IYYSIVGKQS DIVMGSREEF DLMESLIVKE KSTDEESAKR WLGFGNKIVV 

       250        260        270        280        290        300 
IKHGKEGSTA YTNDRKSYKI KPFPVKLLKS FGGGDAYASA FIYGILEEWD IMDALEFGSA 

       310        320        330 
SAAMLVASHS CSEDMPTVKE INEFIKEKKE QYGEMIARG

« Hide

References

[1]"Complete sequence of Clostridium botulinum strain Eklund."
Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Eklund 17B / Type B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001056 Genomic DNA. Translation: ACD24006.1.
RefSeqYP_001885500.1. NC_010674.1.

3D structure databases

ProteinModelPortalB2TJ78.
ModBaseSearch...

Protein-protein interaction databases

STRING508765.CLL_A1302.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD24006; ACD24006; CLL_A1302.
GeneID6292774.
KEGGcbk:CLL_A1302.
PATRIC19395446. VBICloBot123574_1233.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0524.
HOGENOMHOG000235951.
KOK03338.
OMAREECEMA.
ProtClustDBCLSK873289.

Enzyme and pathway databases

BioCycCBOT508765:GJ4H-1296-MONOMER.
UniPathwayUPA00076; UER00146.

Family and domain databases

HAMAPMF_01668. IolC.
InterProIPR002173. Carboh/pur_kinase_PfkB_CS.
IPR022841. DKG_kinase.
IPR011611. PfkB_dom.
[Graphical view]
PfamPF00294. PfkB. 1 hit.
[Graphical view]
PROSITEPS00583. PFKB_KINASES_1. False negative.
PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOLC_CLOBB
AccessionPrimary (citable) accession number: B2TJ78
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: July 1, 2008
Last modified: May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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