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B2TIZ1 (G6PI_CLOBB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:CLL_A0403
OrganismClostridium botulinum (strain Eklund 17B / Type B) [Complete proteome] [HAMAP]
Taxonomic identifier508765 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_1000125708

Sites

Active site3121 By similarity
Active site4261 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2TIZ1 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 3DEA22C4E498C8D7

FASTA44950,336
        10         20         30         40         50         60 
MKKGLTLDLS KTQAFVKDYE LDYMEGMVKD SHDRLHSKTG QGNDFLGWID LPVDYDKEEF 

        70         80         90        100        110        120 
ARIKKAAEKI QSDSDVLIVI GIGGSYLGAR AAIEMLTSNF HNVLDDNKRK VPKIFYAGNN 

       130        140        150        160        170        180 
ISSTYMAELL EAIDGKDVSV NVISKSGTTT EPAIAFRIFK SYLEKKYGVE EARKRIYATT 

       190        200        210        220        230        240 
DKAKGALKGL ADVEGYETFV IPDDVGGRFT VLTPVGLLPI AVAGINIDEM MQGAADAREA 

       250        260        270        280        290        300 
YSNPSLKEND CYKYAVTRNA LYNKGKEIEV LVNYEPCIHY FNEWWKQLYG ESEGKDKKGL 

       310        320        330        340        350        360 
FPAAVDFSTD LHSMGQYIQD GRRNLFETVI NVEKARKEIT IEFSEGDLDG LNFLTGKTMD 

       370        380        390        400        410        420 
FVNNKAFQGT LLAHNDGEVP NMVLNVPELS PYYFGHMVYF FEKACGISGY LLGINPFDQP 

       430        440 
GVEAYKKNMF ALLGKPGYED MKDELEKRL

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References

[1]"Complete sequence of Clostridium botulinum strain Eklund."
Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Eklund 17B / Type B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001056 Genomic DNA. Translation: ACD23777.1.
RefSeqYP_001884638.1. NC_010674.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2TIZ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6291810.
GenomeReviewsGene locus CLL_A0403 in contig CP001056_GR.
KEGGcbk:CLL_A0403.
PATRIC19393661. VBICloBot123574_0372.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG615843.
OMAGQGNDFL.
ProtClustDBPRK14097.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_CLOBB
AccessionPrimary (citable) accession number: B2TIZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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