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B2TIG1

- B2TIG1_CLOBB

UniProt

B2TIG1 - B2TIG1_CLOBB

Protein

Elongation factor Tu

Gene

tuf

Organism
Clostridium botulinum (strain Eklund 17B / Type B)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 268GTPUniRule annotation
    Nucleotide bindingi81 – 855GTPUniRule annotation
    Nucleotide bindingi136 – 1394GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factorUniRule annotationImported

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBOT508765:GJ4H-222-MONOMER.
    CBOT508765:GJ4H-234-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor TuUniRule annotation
    Short name:
    EF-TuUniRule annotation
    Gene namesi
    Name:tufUniRule annotationImported
    Synonyms:tufBImported
    Ordered Locus Names:CLL_A0224Imported, CLL_A0236Imported
    ORF Names:CB17B0192Imported
    OrganismiClostridium botulinum (strain Eklund 17B / Type B)Imported
    Taxonomic identifieri935198 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001195: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi508765.CLL_A0236.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.UniRule annotation
    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0050.
    HOGENOMiHOG000229290.
    KOiK02358.
    OMAiDNIEMVG.
    OrthoDBiEOG6R5C6X.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. EFACTOR_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2TIG1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKEKFERSK PHVNIGTIGH VDHGKTTLTA AITTVLANRG FAEAFNYAEI    50
    DKAPEEKERG ITINTAHVEY ETENRHYAHV DCPGHADYVK NMITGAAQMD 100
    GAILVCSAAD GPMPQTREHI LLASRVGVDY IVVFLNKADM VDDEELLELV 150
    EMEVRELLSE YNFPGDDIPV IKGSALKALE NPTDETAIAP ILELMEAVDS 200
    YIPTPERATD KPFIMPVEDV FTITGRGTVA TGRVETGILH VGDEVEIVGL 250
    SEEKKKVVVT GIEMFRKLLD EAQAGDNIGA LLRGVQRADI ERGQVIAVPN 300
    SVHPHTKFVG QVYVLKKEEG GRHTPFFDGY RPQFYFRTTD VTGSIKLPDG 350
    MEMVMPGDHI DMNVELITPV AMDEGLRFAI REGGRTVGSG VVTKINA 397
    Length:397
    Mass (Da):43,569
    Last modified:July 1, 2008 - v1
    Checksum:i34E040177E382AB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001056 Genomic DNA. Translation: ACD23275.1.
    CP001056 Genomic DNA. Translation: ACD24211.1.
    FR745875 Genomic DNA. Translation: CDH89184.1.
    RefSeqiYP_001884459.1. NC_010674.1.
    YP_001884471.1. NC_010674.1.

    Genome annotation databases

    EnsemblBacteriaiACD23275; ACD23275; CLL_A0236.
    ACD24211; ACD24211; CLL_A0224.
    GeneIDi6292480.
    6293092.
    KEGGicbk:CLL_A0224.
    cbk:CLL_A0236.
    PATRICi19393303. VBICloBot123574_0193.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001056 Genomic DNA. Translation: ACD23275.1 .
    CP001056 Genomic DNA. Translation: ACD24211.1 .
    FR745875 Genomic DNA. Translation: CDH89184.1 .
    RefSeqi YP_001884459.1. NC_010674.1.
    YP_001884471.1. NC_010674.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 508765.CLL_A0236.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD23275 ; ACD23275 ; CLL_A0236 .
    ACD24211 ; ACD24211 ; CLL_A0224 .
    GeneIDi 6292480.
    6293092.
    KEGGi cbk:CLL_A0224.
    cbk:CLL_A0236.
    PATRICi 19393303. VBICloBot123574_0193.

    Phylogenomic databases

    eggNOGi COG0050.
    HOGENOMi HOG000229290.
    KOi K02358.
    OMAi DNIEMVG.
    OrthoDBi EOG6R5C6X.

    Enzyme and pathway databases

    BioCyci CBOT508765:GJ4H-222-MONOMER.
    CBOT508765:GJ4H-234-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. EFACTOR_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Clostridium botulinum strain Eklund."
      Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Eklund 17B / Type BImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Eklund 17BImported.
    3. Shrivastava S., Brinkac L.M., Dodson R.J., Harkins D.M., Durkin A.S., Sutton G.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Eklund 17BImported.
    4. "Genomic and physiological variability within Group II (non-proteolytic) Clostridium botulinum."
      Stringer S.C., Carter A.T., Webb M.D., Wachnicka E., Crossman L.C., Sebaihia M., Peck M.W.
      BMC Genomics 14:333-333(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B str. Eklund 17BImported.

    Entry informationi

    Entry nameiB2TIG1_CLOBB
    AccessioniPrimary (citable) accession number: B2TIG1
    Secondary accession number(s): U4P1I3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3