B2TGB8 (UXUA_BURPP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	Bphyt_5748

Organism

Burkholderia phytofirmans (strain DSM 17436 / PsJN) [Complete proteome] [HAMAP]

Taxonomic identifier

398527 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Mannonate dehydratase HAMAP MF_00106		PRO_1000094213

Sequences

	Sequence		Length	Mass (Da)
	B2TGB8 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: BBDB8EE8005DFA40	FASTA	352	39,033
	10 20 30 40 50 60 MKMTFRWYGD TDPVPLAYIR QIPGMVGVVS AIYDVPVGEV WPIDRIRSLK EKIEAHGLTL 70 80 90 100 110 120 EVIESVPVHE DIKLGKPTRD TLIVNYGQTL RNLGACGVKV VCYNFMPVFD WTRTSLEMPL 130 140 150 160 170 180 PDGSTTLAFD TQAIRELDVS EGIQLPGWDA SYRPEQLKAL LRDYEALDEA GLWANLDYFL 190 200 210 220 230 240 RAIIPVAKEA GIKMAIHPDD PPRPIFGLPR IVKNRADLQR VLDIVDDPAN GLTLCSGSLG 250 260 270 280 290 300 ADLQNDIPAL VREFGARGRI HFAHLRNVQT NAAGDFHETS HRSADGSLDM AEIVKAYFET 310 320 330 340 350 GFEGYARPDH GRMIWGETGR AGYGLFDRAL GAVYLNGIWE GLAKHPADHA AE

References

[1]

"Complete sequence of chromosome 2 of Burkholderia phytofirmans PsJN." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17436 / PsJN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001053 Genomic DNA. Translation: ACD20090.1.
RefSeq	YP_001889461.1. NC_010676.1.
3D structure databases
ProteinModelPortal	B2TGB8.
ModBase	Search...
Protein-protein interaction databases
STRING	B2TGB8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6278551.
GenomeReviews	Gene locus Bphyt_5748 in contig CP001053_GR.
KEGG	bpy:Bphyt_5748.
PATRIC	19206254. VBIBurPhy117947_1929.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG585927.
OMA	DIKLGKP.
ProtClustDB	PRK03906.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_BURPP

Accession

Primary (citable) accession number: B2TGB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program