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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) (Burkholderia phytofirmans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Iron, Manganese

Enzyme and pathway databases

UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:Bphyt_5748
OrganismiParaburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) (Burkholderia phytofirmans)
Taxonomic identifieri398527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000001739 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000942131 – 352Mannonate dehydrataseAdd BLAST352

Interactioni

Protein-protein interaction databases

STRINGi398527.Bphyt_5748.

Structurei

3D structure databases

ProteinModelPortaliB2TGB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
HOGENOMiHOG000195381.
KOiK01686.
OMAiEGDVDMY.
OrthoDBiPOG091H06MP.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA. 1 hit.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2TGB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMTFRWYGD TDPVPLAYIR QIPGMVGVVS AIYDVPVGEV WPIDRIRSLK
60 70 80 90 100
EKIEAHGLTL EVIESVPVHE DIKLGKPTRD TLIVNYGQTL RNLGACGVKV
110 120 130 140 150
VCYNFMPVFD WTRTSLEMPL PDGSTTLAFD TQAIRELDVS EGIQLPGWDA
160 170 180 190 200
SYRPEQLKAL LRDYEALDEA GLWANLDYFL RAIIPVAKEA GIKMAIHPDD
210 220 230 240 250
PPRPIFGLPR IVKNRADLQR VLDIVDDPAN GLTLCSGSLG ADLQNDIPAL
260 270 280 290 300
VREFGARGRI HFAHLRNVQT NAAGDFHETS HRSADGSLDM AEIVKAYFET
310 320 330 340 350
GFEGYARPDH GRMIWGETGR AGYGLFDRAL GAVYLNGIWE GLAKHPADHA

AE
Length:352
Mass (Da):39,033
Last modified:July 1, 2008 - v1
Checksum:iBBDB8EE8005DFA40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001053 Genomic DNA. Translation: ACD20090.1.

Genome annotation databases

EnsemblBacteriaiACD20090; ACD20090; Bphyt_5748.
KEGGibpy:Bphyt_5748.
PATRICi19206254. VBIBurPhy117947_1929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001053 Genomic DNA. Translation: ACD20090.1.

3D structure databases

ProteinModelPortaliB2TGB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi398527.Bphyt_5748.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD20090; ACD20090; Bphyt_5748.
KEGGibpy:Bphyt_5748.
PATRICi19206254. VBIBurPhy117947_1929.

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
HOGENOMiHOG000195381.
KOiK01686.
OMAiEGDVDMY.
OrthoDBiPOG091H06MP.

Enzyme and pathway databases

UniPathwayiUPA00246.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA. 1 hit.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUXUA_PARPJ
AccessioniPrimary (citable) accession number: B2TGB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: November 2, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.