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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) (Burkholderia phytofirmans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandIron, Manganese

Enzyme and pathway databases

UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:Bphyt_5748
OrganismiParaburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) (Burkholderia phytofirmans)
Taxonomic identifieri398527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000001739 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000942131 – 352Mannonate dehydrataseAdd BLAST352

Interactioni

Protein-protein interaction databases

STRINGi398527.Bphyt_5748.

Structurei

3D structure databases

ProteinModelPortaliB2TGB8.
SMRiB2TGB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
HOGENOMiHOG000195381.
KOiK01686.
OMAiRPDHGHL.
OrthoDBiPOG091H06MP.

Family and domain databases

HAMAPiMF_00106. UxuA. 1 hit.
InterProiView protein in InterPro
IPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
PANTHERiPTHR30387:SF3. PTHR30387:SF3. 1 hit.
PfamiView protein in Pfam
PF03786. UxuA. 1 hit.
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2TGB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMTFRWYGD TDPVPLAYIR QIPGMVGVVS AIYDVPVGEV WPIDRIRSLK
60 70 80 90 100
EKIEAHGLTL EVIESVPVHE DIKLGKPTRD TLIVNYGQTL RNLGACGVKV
110 120 130 140 150
VCYNFMPVFD WTRTSLEMPL PDGSTTLAFD TQAIRELDVS EGIQLPGWDA
160 170 180 190 200
SYRPEQLKAL LRDYEALDEA GLWANLDYFL RAIIPVAKEA GIKMAIHPDD
210 220 230 240 250
PPRPIFGLPR IVKNRADLQR VLDIVDDPAN GLTLCSGSLG ADLQNDIPAL
260 270 280 290 300
VREFGARGRI HFAHLRNVQT NAAGDFHETS HRSADGSLDM AEIVKAYFET
310 320 330 340 350
GFEGYARPDH GRMIWGETGR AGYGLFDRAL GAVYLNGIWE GLAKHPADHA

AE
Length:352
Mass (Da):39,033
Last modified:July 1, 2008 - v1
Checksum:iBBDB8EE8005DFA40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001053 Genomic DNA. Translation: ACD20090.1.

Genome annotation databases

EnsemblBacteriaiACD20090; ACD20090; Bphyt_5748.
KEGGibpy:Bphyt_5748.

Similar proteinsi

Entry informationi

Entry nameiUXUA_PARPJ
AccessioniPrimary (citable) accession number: B2TGB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: August 30, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families