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B2TCJ9

- BETB_BURPP

UniProt

B2TCJ9 - BETB_BURPP

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Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB, Bphyt_5059
Organism
Burkholderia phytofirmans (strain DSM 17436 / PsJN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi26 – 261Potassium 1 By similarity
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei162 – 1621Charge relay system By similarity
Metal bindingi180 – 1801Potassium 1; via carbonyl oxygen By similarity
Binding sitei209 – 2091NAD/NADP; via amide nitrogen By similarity
Metal bindingi245 – 2451Potassium 2; via carbonyl oxygen By similarity
Sitei247 – 2471Seems to be a necessary countercharge to the potassium cations By similarity
Active sitei251 – 2511Proton acceptor By similarity
Binding sitei285 – 2851NAD/NADP By similarity
Binding sitei386 – 3861NAD/NADP By similarity
Metal bindingi456 – 4561Potassium 2; via carbonyl oxygen By similarity
Metal bindingi459 – 4591Potassium 2; via carbonyl oxygen By similarity
Active sitei463 – 4631Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1534NAD/NADP By similarity
Nucleotide bindingi176 – 1794NAD/NADP By similarity
Nucleotide bindingi228 – 2336NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciBPHY398527:GJEX-5132-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:Bphyt_5059
OrganismiBurkholderia phytofirmans (strain DSM 17436 / PsJN)
Taxonomic identifieri398527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001739: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation
PRO_1000133945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei285 – 2851Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi398527.Bphyt_5059.

Structurei

3D structure databases

ProteinModelPortaliB2TCJ9.
SMRiB2TCJ9. Positions 4-489.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiPTQIACW.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2TCJ9-1 [UniParc]FASTAAdd to Basket

« Hide

MAVFATQRLY IGGGYVDATS GETFDTLDPA TGETLASVQQ ASAADVDRAV    50
RSAKQGQREW AALTAMQRSR ILRRAVDLLR ERNDELAALE TRDTGKPIAE 100
TLAVDIVTGA DVIEYYAGLA TAIEGQQIPL RPTSFVYTRR EPLGVCAGIG 150
AWNYPIQIAC WKSAPALAAG NAMIFKPSEI TPLSALKLAE IFTEAGVPAG 200
VFNVVQGDGR VGAMLAAHPD IEKISFTGGV ETGKKVMSMA GASSLKEVTM 250
ELGGKSPLLV FDDANLERAA DIATSANFFS SGQVCTNGTR VFVQRGVLDR 300
FEALVLERVK RIRVGKPTDA ATNFGPLVSA AQLHKVLGYI ESGKQEGARL 350
VAGGKRLTEG HFAGGQYVEP TVFADCRDDM RIVREEIFGP VMSILVFDDE 400
DEAIARANHT AYGLAAGVVT ENLARAHRVI HRLEAGICWI NTWGESPAEM 450
PVGGYKQSGV GRENGITTLE HYTRIKSVQV ELGPYQPVF 489
Length:489
Mass (Da):52,478
Last modified:July 1, 2008 - v1
Checksum:i131E1FA2DF8266CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001053 Genomic DNA. Translation: ACD19423.1.
RefSeqiYP_001888793.1. NC_010676.1.

Genome annotation databases

EnsemblBacteriaiACD19423; ACD19423; Bphyt_5059.
GeneIDi6277848.
KEGGibpy:Bphyt_5059.
PATRICi19204763. VBIBurPhy117947_1184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001053 Genomic DNA. Translation: ACD19423.1 .
RefSeqi YP_001888793.1. NC_010676.1.

3D structure databases

ProteinModelPortali B2TCJ9.
SMRi B2TCJ9. Positions 4-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398527.Bphyt_5059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD19423 ; ACD19423 ; Bphyt_5059 .
GeneIDi 6277848.
KEGGi bpy:Bphyt_5059.
PATRICi 19204763. VBIBurPhy117947_1184.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi PTQIACW.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci BPHY398527:GJEX-5132-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia phytofirmans PsJN."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
    , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17436 / PsJN.

Entry informationi

Entry nameiBETB_BURPP
AccessioniPrimary (citable) accession number: B2TCJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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