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B2TCJ8 (BETA_BURPP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1
Gene names
Name:betA
Ordered Locus Names:Bphyt_5058
OrganismBurkholderia phytofirmans (strain DSM 17436 / PsJN) [Complete proteome] [HAMAP]
Taxonomic identifier398527 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750

Cofactor

FAD By similarity. HAMAP MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Choline dehydrogenase HAMAP MF_00750
PRO_1000133325

Regions

Nucleotide binding7 – 3630FAD Potential

Sites

Active site4741 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2TCJ8 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: FF6ACA98B6EAE91F

FASTA56162,134
        10         20         30         40         50         60 
MAANEYDYII VGAGSAGNVL ASRLTEDADV TVLLLEAGGP DYRFDFRTQM PAALAFPLQG 

        70         80         90        100        110        120 
RRYNWAYETD PEPHMNNRRM ECGRGKGLGG SSLINGMCYI RGNALDYDGW AAHAGLENWT 

       130        140        150        160        170        180 
YLDCLPYFRK AETRDAGANA YHGGDGPVHV TTSKPGNNPL FAAMVEAGVQ AGFPRTDDLN 

       190        200        210        220        230        240 
GYQQEGFGPM DRTVTANGRR ASTARGYLDR AKTRPNLTIV THAVTDRVLF SGKRAVGVAY 

       250        260        270        280        290        300 
LHHGNAVNAQ ARREVLVCSG AIASPQLLQR SGVGRSTWLR ELDVPLVHDL PGVGENLQDH 

       310        320        330        340        350        360 
LEMYIQYECK EPISLYPALQ WWNQPAIGLE WMLKGTGIGA SNQFEAGGFI RTRDDDLWPN 

       370        380        390        400        410        420 
IQYHFLPVAI NYNGSNAIKM HGFQAHVGSM RSPSRGRVKL TSRDPNAHPS ILFNYMADPL 

       430        440        450        460        470        480 
DWREFRDGIR ITREIMRQPA LDRYRGRELN PGAELTTDEQ LDTFVRMRAE TAFHPSCSCK 

       490        500        510        520        530        540 
MGYDDMAVVD NEGRVHGMEA LRVVDASIMP RITTGNLNAP TIMLAEKIAD RIHGREPLAR 

       550        560 
VDTPYFVANG VASRKQESAT V

« Hide

References

[1]"Complete sequence of chromosome 2 of Burkholderia phytofirmans PsJN."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17436 / PsJN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001053 Genomic DNA. Translation: ACD19422.1.
RefSeqYP_001888792.1. NC_010676.1.

3D structure databases

ProteinModelPortalB2TCJ8.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2TCJ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6280429.
GenomeReviewsGene locus Bphyt_5058 in contig CP001053_GR.
KEGGbpy:Bphyt_5058.
PATRIC19204761. VBIBurPhy117947_1183.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG734713.
OMARSTAPYY.
ProtClustDBPRK02106.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
[Tree]
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
KOK00108.
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. BetA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_BURPP
AccessionPrimary (citable) accession number: B2TCJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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