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B2TCJ8

- BETA_BURPP

UniProt

B2TCJ8 - BETA_BURPP

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Burkholderia phytofirmans (strain DSM 17436 / PsJN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei474 – 4741UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 3630FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciBPHY398527:GJEX-5131-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:Bphyt_5058
    OrganismiBurkholderia phytofirmans (strain DSM 17436 / PsJN)
    Taxonomic identifieri398527 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001739: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 561561Oxygen-dependent choline dehydrogenasePRO_1000133325Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398527.Bphyt_5058.

    Structurei

    3D structure databases

    ProteinModelPortaliB2TCJ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiTHGAMIS.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2TCJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAANEYDYII VGAGSAGNVL ASRLTEDADV TVLLLEAGGP DYRFDFRTQM    50
    PAALAFPLQG RRYNWAYETD PEPHMNNRRM ECGRGKGLGG SSLINGMCYI 100
    RGNALDYDGW AAHAGLENWT YLDCLPYFRK AETRDAGANA YHGGDGPVHV 150
    TTSKPGNNPL FAAMVEAGVQ AGFPRTDDLN GYQQEGFGPM DRTVTANGRR 200
    ASTARGYLDR AKTRPNLTIV THAVTDRVLF SGKRAVGVAY LHHGNAVNAQ 250
    ARREVLVCSG AIASPQLLQR SGVGRSTWLR ELDVPLVHDL PGVGENLQDH 300
    LEMYIQYECK EPISLYPALQ WWNQPAIGLE WMLKGTGIGA SNQFEAGGFI 350
    RTRDDDLWPN IQYHFLPVAI NYNGSNAIKM HGFQAHVGSM RSPSRGRVKL 400
    TSRDPNAHPS ILFNYMADPL DWREFRDGIR ITREIMRQPA LDRYRGRELN 450
    PGAELTTDEQ LDTFVRMRAE TAFHPSCSCK MGYDDMAVVD NEGRVHGMEA 500
    LRVVDASIMP RITTGNLNAP TIMLAEKIAD RIHGREPLAR VDTPYFVANG 550
    VASRKQESAT V 561
    Length:561
    Mass (Da):62,134
    Last modified:July 1, 2008 - v1
    Checksum:iFF6ACA98B6EAE91F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001053 Genomic DNA. Translation: ACD19422.1.
    RefSeqiWP_012426933.1. NC_010676.1.
    YP_001888792.1. NC_010676.1.

    Genome annotation databases

    EnsemblBacteriaiACD19422; ACD19422; Bphyt_5058.
    GeneIDi6280429.
    KEGGibpy:Bphyt_5058.
    PATRICi19204761. VBIBurPhy117947_1183.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001053 Genomic DNA. Translation: ACD19422.1 .
    RefSeqi WP_012426933.1. NC_010676.1.
    YP_001888792.1. NC_010676.1.

    3D structure databases

    ProteinModelPortali B2TCJ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398527.Bphyt_5058.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD19422 ; ACD19422 ; Bphyt_5058 .
    GeneIDi 6280429.
    KEGGi bpy:Bphyt_5058.
    PATRICi 19204761. VBIBurPhy117947_1183.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi THGAMIS.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci BPHY398527:GJEX-5131-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 2 of Burkholderia phytofirmans PsJN."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
      , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17436 / PsJN.

    Entry informationi

    Entry nameiBETA_BURPP
    AccessioniPrimary (citable) accession number: B2TCJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3