Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B2TCJ8

- BETA_BURPP

UniProt

B2TCJ8 - BETA_BURPP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Burkholderia phytofirmans (strain DSM 17436 / PsJN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei474 – 4741UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 3630FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciBPHY398527:GJEX-5131-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:Bphyt_5058
OrganismiBurkholderia phytofirmans (strain DSM 17436 / PsJN)
Taxonomic identifieri398527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001739: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Oxygen-dependent choline dehydrogenasePRO_1000133325Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398527.Bphyt_5058.

Structurei

3D structure databases

ProteinModelPortaliB2TCJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiTHGAMIS.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2TCJ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAANEYDYII VGAGSAGNVL ASRLTEDADV TVLLLEAGGP DYRFDFRTQM
60 70 80 90 100
PAALAFPLQG RRYNWAYETD PEPHMNNRRM ECGRGKGLGG SSLINGMCYI
110 120 130 140 150
RGNALDYDGW AAHAGLENWT YLDCLPYFRK AETRDAGANA YHGGDGPVHV
160 170 180 190 200
TTSKPGNNPL FAAMVEAGVQ AGFPRTDDLN GYQQEGFGPM DRTVTANGRR
210 220 230 240 250
ASTARGYLDR AKTRPNLTIV THAVTDRVLF SGKRAVGVAY LHHGNAVNAQ
260 270 280 290 300
ARREVLVCSG AIASPQLLQR SGVGRSTWLR ELDVPLVHDL PGVGENLQDH
310 320 330 340 350
LEMYIQYECK EPISLYPALQ WWNQPAIGLE WMLKGTGIGA SNQFEAGGFI
360 370 380 390 400
RTRDDDLWPN IQYHFLPVAI NYNGSNAIKM HGFQAHVGSM RSPSRGRVKL
410 420 430 440 450
TSRDPNAHPS ILFNYMADPL DWREFRDGIR ITREIMRQPA LDRYRGRELN
460 470 480 490 500
PGAELTTDEQ LDTFVRMRAE TAFHPSCSCK MGYDDMAVVD NEGRVHGMEA
510 520 530 540 550
LRVVDASIMP RITTGNLNAP TIMLAEKIAD RIHGREPLAR VDTPYFVANG
560
VASRKQESAT V
Length:561
Mass (Da):62,134
Last modified:July 1, 2008 - v1
Checksum:iFF6ACA98B6EAE91F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001053 Genomic DNA. Translation: ACD19422.1.
RefSeqiWP_012426933.1. NC_010676.1.
YP_001888792.1. NC_010676.1.

Genome annotation databases

EnsemblBacteriaiACD19422; ACD19422; Bphyt_5058.
GeneIDi6280429.
KEGGibpy:Bphyt_5058.
PATRICi19204761. VBIBurPhy117947_1183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001053 Genomic DNA. Translation: ACD19422.1 .
RefSeqi WP_012426933.1. NC_010676.1.
YP_001888792.1. NC_010676.1.

3D structure databases

ProteinModelPortali B2TCJ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398527.Bphyt_5058.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD19422 ; ACD19422 ; Bphyt_5058 .
GeneIDi 6280429.
KEGGi bpy:Bphyt_5058.
PATRICi 19204761. VBIBurPhy117947_1183.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi THGAMIS.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci BPHY398527:GJEX-5131-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia phytofirmans PsJN."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
    , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17436 / PsJN.

Entry informationi

Entry nameiBETA_BURPP
AccessioniPrimary (citable) accession number: B2TCJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3