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Protein

3-deoxy-manno-octulosonate cytidylyltransferase 2

Gene

kdsB2

Organism
Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) (Burkholderia phytofirmans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi: CMP-3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase 2 (kdsB2), 3-deoxy-manno-octulosonate cytidylyltransferase 1 (kdsB1)
This subpathway is part of the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP, the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis and in Nucleotide-sugar biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00030
UPA00358; UER00476

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferase 2UniRule annotation (EC:2.7.7.38UniRule annotation)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase 2UniRule annotation
Short name:
CKS 2UniRule annotation
Short name:
CMP-KDO synthase 2UniRule annotation
Gene namesi
Name:kdsB2UniRule annotation
Ordered Locus Names:Bphyt_6258
OrganismiParaburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) (Burkholderia phytofirmans)
Taxonomic identifieri398527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000001739 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003700341 – 2633-deoxy-manno-octulosonate cytidylyltransferase 2Add BLAST263

Interactioni

Protein-protein interaction databases

STRINGi398527.Bphyt_6258

Structurei

3D structure databases

ProteinModelPortaliB2TAY9
SMRiB2TAY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CET Bacteria
COG1212 LUCA
HOGENOMiHOG000007602
KOiK00979
OMAiIRICEAR
OrthoDBiPOG091H00UN

Family and domain databases

CDDicd02517 CMP-KDO-Synthetase, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00057 KdsB, 1 hit
InterProiView protein in InterPro
IPR003329 Cytidylyl_trans
IPR004528 KdsB
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF02348 CTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR00466 kdsB, 1 hit

Sequencei

Sequence statusi: Complete.

B2TAY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSSDPASI HVVIPARFGS TRLPGKPLID LAGEPMIVRV YEAVRAALPE
60 70 80 90 100
TVNIVVATDD ERIVGSLEAY RIPVRMTDPE HQSGTDRCAQ VARELGWNSD
110 120 130 140 150
DLVVNVQGDE PLVPQPLLAS FVQFCANAQA FDMATVAVPL TEVSHLTDPN
160 170 180 190 200
VVKLVVGAQG QAIVFSRSAI PFCRDLPQNE WPLSAYLRHV GIYAYRCSAL
210 220 230 240 250
YRLTETPSCE LEELERLEQM RAIWLGMPIR VFEWPEPPPP GVDTKEDVAR
260
VREILFVNAS GRS
Length:263
Mass (Da):29,101
Last modified:July 1, 2008 - v1
Checksum:iA312D8EE67ED3AB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001053 Genomic DNA Translation: ACD20585.1
RefSeqiWP_012428093.1, NC_010676.1

Genome annotation databases

EnsemblBacteriaiACD20585; ACD20585; Bphyt_6258
KEGGibpy:Bphyt_6258

Similar proteinsi

Entry informationi

Entry nameiKDSB2_PARPJ
AccessioniPrimary (citable) accession number: B2TAY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health