Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B2TA75

- B2TA75_BURPP

UniProt

B2TA75 - B2TA75_BURPP

Protein

Diaminopimelate decarboxylase

Gene

lysA

Organism
Burkholderia phytofirmans (strain DSM 17436 / PsJN)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.UniRule annotation

    Catalytic activityi

    Meso-2,6-diaminoheptanedioate = L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei219 – 2191Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei263 – 2631SubstrateUniRule annotation
    Binding sitei299 – 2991SubstrateUniRule annotation
    Binding sitei303 – 3031SubstrateUniRule annotation
    Binding sitei334 – 3341SubstrateUniRule annotation
    Binding sitei369 – 3691Pyridoxal phosphateUniRule annotation
    Binding sitei369 – 3691SubstrateUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate decarboxylase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotationSAAS annotation, Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBPHY398527:GJEX-7166-MONOMER.
    UniPathwayiUPA00034; UER00027.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)
    Short name:
    DAP decarboxylaseUniRule annotation
    Short name:
    DAPDCUniRule annotation
    Gene namesi
    Name:lysAUniRule annotation
    Ordered Locus Names:Bphyt_7089Imported
    OrganismiBurkholderia phytofirmans (strain DSM 17436 / PsJN)Imported
    Taxonomic identifieri398527 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001739: Chromosome 2

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi398527.Bphyt_7089.

    Structurei

    3D structure databases

    ProteinModelPortaliB2TA75.
    SMRiB2TA75. Positions 6-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni260 – 2634Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0019.
    HOGENOMiHOG000045070.
    KOiK01586.
    OMAiTRIRENC.
    OrthoDBiEOG6Z9B18.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_02120. LysA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002986. DAP_deCOOHase_LysA.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PRINTSiPR01181. DAPDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01048. lysA. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2TA75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPFNPQQLVE LAHEHGTPLW VYDADTIRRR IAELRSFDVI RYAQKACSNL    50
    HILKLMRDEG AMVDAVSLGE IKRSLAAGFK PDGDPEGVVF TADLIDHATL 100
    ATVIEHRITV NAGSLDMLEQ IGRHAPEGHR VWLRINPGFG HGHSNKTNTG 150
    GEHSKHGIWL DDVPRAVELV RRYRLKLVGL HMHIGSGVDY GHLSRVCEAM 200
    VEAVKGLGHD IEAISAGGGL SVPYREGEPD IDVAHYFRLW DAARRQIETH 250
    VGHRVRLEIE PGRFLVAQSG VLVAEVHALN RRPAQQFALL DAGFNDLVRP 300
    SFYGSHHEMT VLRRDGALSE APIDSFAVAG PLCEAGDVFT QAESGVITNR 350
    SIHTPEVGDF IVFHDAGAYG ASMSSNYNSR PLAPEVLLDH GKPRLIRRRQ 400
    TIDELLALEE TAA 413
    Length:413
    Mass (Da):45,539
    Last modified:July 1, 2008 - v1
    Checksum:i9F021CE2A1EE4E53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001053 Genomic DNA. Translation: ACD21377.1.
    RefSeqiWP_012428873.1. NC_010676.1.
    YP_001890748.1. NC_010676.1.

    Genome annotation databases

    EnsemblBacteriaiACD21377; ACD21377; Bphyt_7089.
    GeneIDi6277930.
    KEGGibpy:Bphyt_7089.
    PATRICi19209169. VBIBurPhy117947_3379.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001053 Genomic DNA. Translation: ACD21377.1 .
    RefSeqi WP_012428873.1. NC_010676.1.
    YP_001890748.1. NC_010676.1.

    3D structure databases

    ProteinModelPortali B2TA75.
    SMRi B2TA75. Positions 6-402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398527.Bphyt_7089.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD21377 ; ACD21377 ; Bphyt_7089 .
    GeneIDi 6277930.
    KEGGi bpy:Bphyt_7089.
    PATRICi 19209169. VBIBurPhy117947_3379.

    Phylogenomic databases

    eggNOGi COG0019.
    HOGENOMi HOG000045070.
    KOi K01586.
    OMAi TRIRENC.
    OrthoDBi EOG6Z9B18.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00027 .
    BioCyci BPHY398527:GJEX-7166-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_02120. LysA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002986. DAP_deCOOHase_LysA.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PRINTSi PR01181. DAPDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01048. lysA. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 2 of Burkholderia phytofirmans PsJN."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
      , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17436 / PsJNImported.

    Entry informationi

    Entry nameiB2TA75_BURPP
    AccessioniPrimary (citable) accession number: B2TA75
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3