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B2TA75

- B2TA75_BURPP

UniProt

B2TA75 - B2TA75_BURPP

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Protein

Diaminopimelate decarboxylase

Gene
lysA, Bphyt_7089
Organism
Burkholderia phytofirmans (strain DSM 17436 / PsJN)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine By similarity.UniRule annotation

Catalytic activityi

Meso-2,6-diaminoheptanedioate = L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei219 – 2191Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei263 – 2631Substrate By similarityUniRule annotation
Binding sitei299 – 2991Substrate By similarityUniRule annotation
Binding sitei303 – 3031Substrate By similarityUniRule annotation
Binding sitei334 – 3341Substrate By similarityUniRule annotation
Binding sitei369 – 3691Pyridoxal phosphate By similarityUniRule annotation
Binding sitei369 – 3691Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. diaminopimelate decarboxylase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotations, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBPHY398527:GJEX-7166-MONOMER.
UniPathwayiUPA00034; UER00027.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)
Short name:
DAP decarboxylaseUniRule annotation
Short name:
DAPDCUniRule annotation
Gene namesi
Name:lysAUniRule annotation
Ordered Locus Names:Bphyt_7089Imported
OrganismiBurkholderia phytofirmans (strain DSM 17436 / PsJN)Imported
Taxonomic identifieri398527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001739: Chromosome 2

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi398527.Bphyt_7089.

Structurei

3D structure databases

ProteinModelPortaliB2TA75.
SMRiB2TA75. Positions 6-402.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni260 – 2634Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0019.
HOGENOMiHOG000045070.
KOiK01586.
OMAiTRIRENC.
OrthoDBiEOG6Z9B18.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_02120. LysA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01048. lysA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2TA75-1 [UniParc]FASTAAdd to Basket

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MPFNPQQLVE LAHEHGTPLW VYDADTIRRR IAELRSFDVI RYAQKACSNL    50
HILKLMRDEG AMVDAVSLGE IKRSLAAGFK PDGDPEGVVF TADLIDHATL 100
ATVIEHRITV NAGSLDMLEQ IGRHAPEGHR VWLRINPGFG HGHSNKTNTG 150
GEHSKHGIWL DDVPRAVELV RRYRLKLVGL HMHIGSGVDY GHLSRVCEAM 200
VEAVKGLGHD IEAISAGGGL SVPYREGEPD IDVAHYFRLW DAARRQIETH 250
VGHRVRLEIE PGRFLVAQSG VLVAEVHALN RRPAQQFALL DAGFNDLVRP 300
SFYGSHHEMT VLRRDGALSE APIDSFAVAG PLCEAGDVFT QAESGVITNR 350
SIHTPEVGDF IVFHDAGAYG ASMSSNYNSR PLAPEVLLDH GKPRLIRRRQ 400
TIDELLALEE TAA 413
Length:413
Mass (Da):45,539
Last modified:July 1, 2008 - v1
Checksum:i9F021CE2A1EE4E53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001053 Genomic DNA. Translation: ACD21377.1.
RefSeqiWP_012428873.1. NC_010676.1.
YP_001890748.1. NC_010676.1.

Genome annotation databases

EnsemblBacteriaiACD21377; ACD21377; Bphyt_7089.
GeneIDi6277930.
KEGGibpy:Bphyt_7089.
PATRICi19209169. VBIBurPhy117947_3379.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001053 Genomic DNA. Translation: ACD21377.1 .
RefSeqi WP_012428873.1. NC_010676.1.
YP_001890748.1. NC_010676.1.

3D structure databases

ProteinModelPortali B2TA75.
SMRi B2TA75. Positions 6-402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398527.Bphyt_7089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD21377 ; ACD21377 ; Bphyt_7089 .
GeneIDi 6277930.
KEGGi bpy:Bphyt_7089.
PATRICi 19209169. VBIBurPhy117947_3379.

Phylogenomic databases

eggNOGi COG0019.
HOGENOMi HOG000045070.
KOi K01586.
OMAi TRIRENC.
OrthoDBi EOG6Z9B18.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00027 .
BioCyci BPHY398527:GJEX-7166-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_02120. LysA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PRINTSi PR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01048. lysA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia phytofirmans PsJN."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
    , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17436 / PsJN.

Entry informationi

Entry nameiB2TA75_BURPP
AccessioniPrimary (citable) accession number: B2TA75
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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