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B2T7I8

- GCSP_BURPP

UniProt

B2T7I8 - GCSP_BURPP

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Burkholderia phytofirmans (strain DSM 17436 / PsJN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBPHY398527:GJEX-3945-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Bphyt_3882
    OrganismiBurkholderia phytofirmans (strain DSM 17436 / PsJN)
    Taxonomic identifieri398527 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001739: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 978978Glycine dehydrogenase (decarboxylating)PRO_1000190211Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei726 – 7261N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi398527.Bphyt_3882.

    Structurei

    3D structure databases

    ProteinModelPortaliB2T7I8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiAELMPVS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2T7I8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLEHPDRLM NRTPLSLAAL EVHDAFAERH IGPDAADQHA MLEALGFASR    50
    AALIDAVIPK TIRRTETLPL GPFTQPKSEA EALAALRELA DKNQVFRSYI 100
    GQGYYNAHTP TVILRNVLEN PAWYTAYTPY QPEISQGRLE ALLNFQQMIV 150
    DLTGLAISNA SLLDEATAAA EAMTLLQRVG KPKSNVFFVA DDVLPQTIEV 200
    VRTRATPVGI EVKVGPASEA ANANAFGVLL QYPGVNGDVR DYRALTEAIH 250
    AAGGHVVVAA DLLALTVLTP PGEWGADVAV GNTQRFGVPV GFGGPHAAYL 300
    AVRDEFKRQM PGRLVGVTVD AQGNPALRLA LQTREQHIRR EKATSNVCTA 350
    QALLAIMASM YAVYHGPHGL KTIALRVNRI AALLAEGAKQ LGYTLANETF 400
    FDTLTFDTGA RTQALLDAAT AKRINLRRVS ATQVGLSIDE TTTRHDLADL 450
    LAVFAQAAFT NDVPQVDALD AKLAASNTAS VPAALERTSA YLTHHVFNRH 500
    HSETEMLRYL RSLSDKDLAL DRSMIPLGSC TMKLNATSEM LPVTWPEFGQ 550
    IHPFAPAEQT VGYREMIDQL EEMLVAATGY AAVSLQPNAG SQGEYAGLLI 600
    IHAYHASRGE AHRNVCLIPA SAHGTNPASA QMAGMQVVVV ACDAQGNVDI 650
    EDLKKKAGQH ADKLAAIMIT YPSTHGVFEQ NVREICEIVH AHGGQVYVDG 700
    ANMNAMVGLT APGQFGGDVS HLNLHKTFCI PHGGGGPGVG PVAVGAHLAQ 750
    FLPNQISSGY ERAPNGIGAV SGAPYGSASI LPISWMYIAM MGAKNLTAAT 800
    ETAILNANYV AKKLAPHYPV LYSGPGGLVA HECILDLRPI KETSGITVDD 850
    VAKRLADYGF HAPTMSFPVP GTLMVEPTES ESKEELDRFI EAMIAIREEI 900
    RAVEDGRSDR EDNPLKHAPH TAAVVIANDW KHAYARETAA YPLPTLIAKK 950
    YWPPVGRADN VYGDRNLFCS CVPIADYE 978
    Length:978
    Mass (Da):105,136
    Last modified:July 1, 2008 - v1
    Checksum:iB2DA4FFE230474A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001052 Genomic DNA. Translation: ACD18269.1.
    RefSeqiWP_012434789.1. NC_010681.1.
    YP_001897493.1. NC_010681.1.

    Genome annotation databases

    EnsemblBacteriaiACD18269; ACD18269; Bphyt_3882.
    GeneIDi6282817.
    KEGGibpy:Bphyt_3882.
    PATRICi19218389. VBIBurPhy117947_7924.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001052 Genomic DNA. Translation: ACD18269.1 .
    RefSeqi WP_012434789.1. NC_010681.1.
    YP_001897493.1. NC_010681.1.

    3D structure databases

    ProteinModelPortali B2T7I8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398527.Bphyt_3882.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD18269 ; ACD18269 ; Bphyt_3882 .
    GeneIDi 6282817.
    KEGGi bpy:Bphyt_3882.
    PATRICi 19218389. VBIBurPhy117947_7924.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi AELMPVS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BPHY398527:GJEX-3945-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia phytofirmans PsJN."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
      , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17436 / PsJN.

    Entry informationi

    Entry nameiGCSP_BURPP
    AccessioniPrimary (citable) accession number: B2T7I8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3