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B2T7I8

- GCSP_BURPP

UniProt

B2T7I8 - GCSP_BURPP

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Bphyt_3882
Organism
Burkholderia phytofirmans (strain DSM 17436 / PsJN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBPHY398527:GJEX-3945-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Bphyt_3882
OrganismiBurkholderia phytofirmans (strain DSM 17436 / PsJN)
Taxonomic identifieri398527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001739: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 978978Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000190211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei726 – 7261N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi398527.Bphyt_3882.

Structurei

3D structure databases

ProteinModelPortaliB2T7I8.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B2T7I8-1 [UniParc]FASTAAdd to Basket

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MKLEHPDRLM NRTPLSLAAL EVHDAFAERH IGPDAADQHA MLEALGFASR    50
AALIDAVIPK TIRRTETLPL GPFTQPKSEA EALAALRELA DKNQVFRSYI 100
GQGYYNAHTP TVILRNVLEN PAWYTAYTPY QPEISQGRLE ALLNFQQMIV 150
DLTGLAISNA SLLDEATAAA EAMTLLQRVG KPKSNVFFVA DDVLPQTIEV 200
VRTRATPVGI EVKVGPASEA ANANAFGVLL QYPGVNGDVR DYRALTEAIH 250
AAGGHVVVAA DLLALTVLTP PGEWGADVAV GNTQRFGVPV GFGGPHAAYL 300
AVRDEFKRQM PGRLVGVTVD AQGNPALRLA LQTREQHIRR EKATSNVCTA 350
QALLAIMASM YAVYHGPHGL KTIALRVNRI AALLAEGAKQ LGYTLANETF 400
FDTLTFDTGA RTQALLDAAT AKRINLRRVS ATQVGLSIDE TTTRHDLADL 450
LAVFAQAAFT NDVPQVDALD AKLAASNTAS VPAALERTSA YLTHHVFNRH 500
HSETEMLRYL RSLSDKDLAL DRSMIPLGSC TMKLNATSEM LPVTWPEFGQ 550
IHPFAPAEQT VGYREMIDQL EEMLVAATGY AAVSLQPNAG SQGEYAGLLI 600
IHAYHASRGE AHRNVCLIPA SAHGTNPASA QMAGMQVVVV ACDAQGNVDI 650
EDLKKKAGQH ADKLAAIMIT YPSTHGVFEQ NVREICEIVH AHGGQVYVDG 700
ANMNAMVGLT APGQFGGDVS HLNLHKTFCI PHGGGGPGVG PVAVGAHLAQ 750
FLPNQISSGY ERAPNGIGAV SGAPYGSASI LPISWMYIAM MGAKNLTAAT 800
ETAILNANYV AKKLAPHYPV LYSGPGGLVA HECILDLRPI KETSGITVDD 850
VAKRLADYGF HAPTMSFPVP GTLMVEPTES ESKEELDRFI EAMIAIREEI 900
RAVEDGRSDR EDNPLKHAPH TAAVVIANDW KHAYARETAA YPLPTLIAKK 950
YWPPVGRADN VYGDRNLFCS CVPIADYE 978
Length:978
Mass (Da):105,136
Last modified:July 1, 2008 - v1
Checksum:iB2DA4FFE230474A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001052 Genomic DNA. Translation: ACD18269.1.
RefSeqiWP_012434789.1. NC_010681.1.
YP_001897493.1. NC_010681.1.

Genome annotation databases

EnsemblBacteriaiACD18269; ACD18269; Bphyt_3882.
GeneIDi6282817.
KEGGibpy:Bphyt_3882.
PATRICi19218389. VBIBurPhy117947_7924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001052 Genomic DNA. Translation: ACD18269.1 .
RefSeqi WP_012434789.1. NC_010681.1.
YP_001897493.1. NC_010681.1.

3D structure databases

ProteinModelPortali B2T7I8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 398527.Bphyt_3882.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD18269 ; ACD18269 ; Bphyt_3882 .
GeneIDi 6282817.
KEGGi bpy:Bphyt_3882.
PATRICi 19218389. VBIBurPhy117947_7924.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BPHY398527:GJEX-3945-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia phytofirmans PsJN."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
    , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17436 / PsJN.

Entry informationi

Entry nameiGCSP_BURPP
AccessioniPrimary (citable) accession number: B2T7I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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