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B2T672 (ADE_BURPP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2
Alternative name(s):
Adenine aminohydrolase
Short name=AAH
Gene names
Ordered Locus Names:Bphyt_3044
OrganismBurkholderia phytofirmans (strain DSM 17436 / PsJN) [Complete proteome] [HAMAP]
Taxonomic identifier398527 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962

Catalytic activity

Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Adenine deaminase HAMAP MF_01962
PRO_1000128835

Sites

Active site2101Proton donor By similarity
Metal binding241Zinc; catalytic By similarity
Metal binding261Zinc; catalytic By similarity
Metal binding2071Zinc; catalytic By similarity
Metal binding2881Zinc; catalytic By similarity
Binding site2891Substrate By similarity
Site2311Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
B2T672 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 1046B8E88942CEAE

FASTA35038,771
        10         20         30         40         50         60 
MTTTTVTPTP LAEKTALAPK AELHIHIEGS LEPELIFALA ERNGVKLAYD SIDALRAAYA 

        70         80         90        100        110        120 
FTDLQSFLDI YYAGASVLLH EQDFYDMTMA YVERCLADNV IHSEIFFDPQ THTERGVPIA 

       130        140        150        160        170        180 
TVVAGIERAL ADAEKRGMTS KLILCFLRHL SEEDALATFE EALPLFEQYK HRLIGVGLDS 

       190        200        210        220        230        240 
SERGHPPSKF ERVFAKARAL GLKLVAHAGE EGPPSYIYEA LDLLKVDRVD HGVRSIEDPA 

       250        260        270        280        290        300 
LVTRLADSRV ALTVCPLSNL KLCVFDDLTK HTLKDLLDRG VAVTVNSDDP AYFGGYVNAN 

       310        320        330        340        350 
YFATIDALKL NDAEVYTIIR NSFEASFVTP EQRSELIAKL DAHWHPSGPH

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia phytofirmans PsJN."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17436 / PsJN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001052 Genomic DNA. Translation: ACD17436.1.
RefSeqYP_001896660.1. NC_010681.1.

3D structure databases

ProteinModelPortalB2T672.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2T672.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6283244.
GenomeReviewsGene locus Bphyt_3044 in contig CP001052_GR.
KEGGbpy:Bphyt_3044.
PATRIC19216530. VBIBurPhy117947_7019.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG630382.
OMASYIYEAL.
ProtClustDBPRK09358.

Family and domain databases

HAMAPMF_01962. Adenine_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameADE_BURPP
AccessionPrimary (citable) accession number: B2T672
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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