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Protein

Ubiquinone biosynthesis O-methyltransferase

Gene

ubiG

Organism
Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) (Burkholderia phytofirmans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361S-adenosyl-L-methionineUniRule annotation
Binding sitei55 – 551S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei76 – 761S-adenosyl-L-methionineUniRule annotation
Binding sitei120 – 1201S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBPHY398527:GJEX-3049-MONOMER.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferaseUniRule annotation
Alternative name(s):
2-polyprenyl-6-hydroxyphenol methylaseUniRule annotation (EC:2.1.1.222UniRule annotation)
3-demethylubiquinone 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Gene namesi
Name:ubiGUniRule annotation
Ordered Locus Names:Bphyt_3011
OrganismiParaburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) (Burkholderia phytofirmans)
Taxonomic identifieri398527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000001739 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Ubiquinone biosynthesis O-methyltransferasePRO_1000199674Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398527.Bphyt_3011.

Structurei

3D structure databases

ProteinModelPortaliB2T641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108HWB. Bacteria.
COG2227. LUCA.
HOGENOMiHOG000278065.
KOiK00568.
OMAiVNYMLAC.
OrthoDBiPOG091H064Z.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.

Sequencei

Sequence statusi: Complete.

B2T641-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNADPHELQ KFSDLAHRWW DPNAEFKPLH ELNPIRLKWI DAHAHLAGKT
60 70 80 90 100
VLDIGCGGGI LSESMAGLGA HVKGIDLSTQ ALGVADLHSL ESGVTVDYEE
110 120 130 140 150
IAAEALAARE PAKYDVVTCM EMLEHVPQPA AIVEACKTLV KPGGWVFFST
160 170 180 190 200
LNRNVKSYLF AVIGAEYIAR MLPKGTHDYA RFIRPSELAS FVRAADLRTA
210 220 230
DIKGIVYNPL SKHFMLSADT SVNYMLACRR DV
Length:232
Mass (Da):25,530
Last modified:July 1, 2008 - v1
Checksum:i2B0F8C8EF12EC619
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001052 Genomic DNA. Translation: ACD17405.1.
RefSeqiWP_012433984.1. NC_010681.1.

Genome annotation databases

EnsemblBacteriaiACD17405; ACD17405; Bphyt_3011.
KEGGibpy:Bphyt_3011.
PATRICi19216454. VBIBurPhy117947_6981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001052 Genomic DNA. Translation: ACD17405.1.
RefSeqiWP_012433984.1. NC_010681.1.

3D structure databases

ProteinModelPortaliB2T641.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi398527.Bphyt_3011.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD17405; ACD17405; Bphyt_3011.
KEGGibpy:Bphyt_3011.
PATRICi19216454. VBIBurPhy117947_6981.

Phylogenomic databases

eggNOGiENOG4108HWB. Bacteria.
COG2227. LUCA.
HOGENOMiHOG000278065.
KOiK00568.
OMAiVNYMLAC.
OrthoDBiPOG091H064Z.

Enzyme and pathway databases

UniPathwayiUPA00232.
BioCyciBPHY398527:GJEX-3049-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBIG_PARPJ
AccessioniPrimary (citable) accession number: B2T641
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.