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B2T5I1

- LPXB_BURPP

UniProt

B2T5I1 - LPXB_BURPP

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Bphyt_2442
Organism
Burkholderia phytofirmans (strain DSM 17436 / PsJN)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBPHY398527:GJEX-2462-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Bphyt_2442
OrganismiBurkholderia phytofirmans (strain DSM 17436 / PsJN)
Taxonomic identifieri398527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001739: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000191468Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398527.Bphyt_2442.

Structurei

3D structure databases

ProteinModelPortaliB2T5I1.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B2T5I1-1 [UniParc]FASTAAdd to Basket

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MALQPSPLRV AMVAGEPSGD LLAASLLDGL TSRLPAGTQY YGIGGPRMIA    50
TGFDAHFPME KLSVRGYVEA LKHIPGILGI RNELKRQLLA EPPSVFVGVD 100
APDFNFGLEH PLREAGIPTV HFVCPSIWAW RGGRIKKIAK AVDHMLCVFP 150
FETALLEKAG VAASYVGHPL ADEIPLVPDT LGARRALGLA QDGPIIAVLP 200
GSRRSEIDLI GPTFFAAMEM MQHQEPNLRF VMPAATPALR EMLRPLVDSH 250
PGLALTITDG QAQLAMTAAD AILVKSGTVT LEAALLKKPM VISYKVPWLT 300
GQIMRRQGYL PYVGLPNILA GRFVVPEILQ HFATPQALAE ATLKQLRDET 350
NRRTLTEIFT EMHHVLKQNT AQRAAEVVAS VIEKRKGRP 389
Length:389
Mass (Da):42,289
Last modified:July 1, 2008 - v1
Checksum:i8D9D334B4775203E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001052 Genomic DNA. Translation: ACD16838.1.
RefSeqiYP_001896062.1. NC_010681.1.

Genome annotation databases

EnsemblBacteriaiACD16838; ACD16838; Bphyt_2442.
GeneIDi6284042.
KEGGibpy:Bphyt_2442.
PATRICi19215160. VBIBurPhy117947_6352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001052 Genomic DNA. Translation: ACD16838.1 .
RefSeqi YP_001896062.1. NC_010681.1.

3D structure databases

ProteinModelPortali B2T5I1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398527.Bphyt_2442.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD16838 ; ACD16838 ; Bphyt_2442 .
GeneIDi 6284042.
KEGGi bpy:Bphyt_2442.
PATRICi 19215160. VBIBurPhy117947_6352.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci BPHY398527:GJEX-2462-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia phytofirmans PsJN."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
    , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17436 / PsJN.

Entry informationi

Entry nameiLPXB_BURPP
AccessioniPrimary (citable) accession number: B2T5I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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