B2T2S7 (B2T2S7_BURPP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800

Gene names

Ordered Locus Names:

Bphyt_1473

Organism

Burkholderia phytofirmans (strain DSM 17436 / PsJN) [Complete proteome] [HAMAP] EMBL ACD15888.1

Taxonomic identifier

398527 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800
Catalytic activity	L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038800
Pathway	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800
Subunit structure	Homodimer By similarity. PIRNR PIRNR038800
Sequence similarities	Belongs to the kynureninase family. PIRNR PIRNR038800

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis PIRNR PIRNR038800
Ligand	Pyridoxal phosphate PIRNR PIRNR038800
Molecular function	Hydrolase PIRNR PIRNR038800
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro tryptophan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2T2S7 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 313959FD62178E41	FASTA	409	44,548
	10 20 30 40 50 60 MITREHCAAL DAADTLAHCR ARFDLPADTI YLDGNSLGAM PANVPARIEQ ALKHEWAHGL 70 80 90 100 110 120 IRSWNDAGWY PAPQRTGNKI ARLIGAGQDE VIVADSTSVN LFKVLVAATR MRPGRNVILA 130 140 150 160 170 180 ERTNFPTDVY IASSVAEMTG CDLRCVDPDE IVSAIDDTVA IVSLTHVNYK TGKRYDMEAV 190 200 210 220 230 240 TRQAQEAGAL IVWDLCHSAG AMPVNLNRCD ADFAVGCGYK YLNGGPGAPA FVFVASRHIE 250 260 270 280 290 300 AVRQPLTGWH GHSRPFEFAH DYAPHPGIDR MLTGTAPQLG VIALESALEA FDGVDLDVLR 310 320 330 340 350 360 DKSVALGNLF IELTDQELTG LGCTLASPRD AEMRGSQVSL GHAQGYAIMQ ALIARNVIGD 370 380 390 400 FRAPDILRFG FAPLYVRYVD IWDTIAQLKD IIATDAWNTD EFKARKSVT

References

[1]

"Complete sequence of chromosome 1 of Burkholderia phytofirmans PsJN." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001052 Genomic DNA. Translation: ACD15888.1.
RefSeq	YP_001895112.1. NC_010681.1.
3D structure databases
ProteinModelPortal	B2T2S7.
SMR	B2T2S7. Positions 3-397.
ModBase	Search...
Protein-protein interaction databases
STRING	B2T2S7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6284103.
GenomeReviews	Gene locus Bphyt_1473 in contig CP001052_GR.
KEGG	bpy:Bphyt_1473.
PATRIC	19213010. VBIBurPhy117947_5284.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG523016.
OMA	NFPTDVY.
ProtClustDB	CLSK769898.
Family and domain databases
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K01556.
PANTHER	PTHR14084. Kynureninase. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PIRSF	PIRSF038800. KYNU. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01814. Kynureninase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B2T2S7_BURPP

Accession

Primary (citable) accession number: B2T2S7

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)