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B2T2S1 (ACDH_BURPP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Ordered Locus Names:Bphyt_1467
OrganismBurkholderia phytofirmans (strain DSM 17436 / PsJN) [Complete proteome] [HAMAP]
Taxonomic identifier398527 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387633

Regions

Nucleotide binding15 – 184NAD By similarity
Nucleotide binding164 – 1729NAD By similarity

Sites

Active site1331Acyl-thioester intermediate By similarity
Binding site2921NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B2T2S1 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 3A5BF970A913576E

FASTA31432,943
        10         20         30         40         50         60 
MYDKQDKQAV AIIGSGNIGT DLMIKVLRDA KHLEMGAMVG IDPASDGLAR AKRLGVATTA 

        70         80         90        100        110        120 
HGIEGLVTMP NFGAIRIAFD ATSAGAHHRH AAVLREHGVT VIDLTPAAIG PFVVPVVNLF 

       130        140        150        160        170        180 
AHLDAPNLNM VTCGGQATIP IVHAVSRVAP VRYAEIVASI ASRSAGPGTR ANIDEFTETT 

       190        200        210        220        230        240 
SKAIETVGGA ARGKAIIVLN PAEPPLMMRD TVYCLTEEEA DTDEIESSIR AMVSAVASYV 

       250        260        270        280        290        300 
PGYRLKQAVQ FDRYTAANPL ALHANERRAG LKVSVFLEVE GAAHYLPSYA GNLDIMTSAA 

       310 
LAAAEQIAAS RVAA 

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia phytofirmans PsJN."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17436 / PsJN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001052 Genomic DNA. Translation: ACD15882.1.
RefSeqYP_001895106.1. NC_010681.1.

3D structure databases

ProteinModelPortalB2T2S1.
SMRB2T2S1. Positions 7-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING398527.Bphyt_1467.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD15882; ACD15882; Bphyt_1467.
GeneID6282498.
KEGGbpy:Bphyt_1467.
PATRIC19212998. VBIBurPhy117947_5278.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAHARHEQL.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycBPHY398527:GJEX-1480-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_BURPP
AccessionPrimary (citable) accession number: B2T2S1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families