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B2T2S1

- ACDH_BURPP

UniProt

B2T2S1 - ACDH_BURPP

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Protein
Acetaldehyde dehydrogenase
Gene
Bphyt_1467
Organism
Burkholderia phytofirmans (strain DSM 17436 / PsJN)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Acyl-thioester intermediate By similarity
Binding sitei292 – 2921NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 184NAD By similarity
Nucleotide bindingi164 – 1729NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBPHY398527:GJEX-1480-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene namesi
Ordered Locus Names:Bphyt_1467
OrganismiBurkholderia phytofirmans (strain DSM 17436 / PsJN)
Taxonomic identifieri398527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001739: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Acetaldehyde dehydrogenaseUniRule annotation
PRO_0000387633Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398527.Bphyt_1467.

Structurei

3D structure databases

ProteinModelPortaliB2T2S1.
SMRiB2T2S1. Positions 7-314.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiHARHEQL.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

B2T2S1-1 [UniParc]FASTAAdd to Basket

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MYDKQDKQAV AIIGSGNIGT DLMIKVLRDA KHLEMGAMVG IDPASDGLAR    50
AKRLGVATTA HGIEGLVTMP NFGAIRIAFD ATSAGAHHRH AAVLREHGVT 100
VIDLTPAAIG PFVVPVVNLF AHLDAPNLNM VTCGGQATIP IVHAVSRVAP 150
VRYAEIVASI ASRSAGPGTR ANIDEFTETT SKAIETVGGA ARGKAIIVLN 200
PAEPPLMMRD TVYCLTEEEA DTDEIESSIR AMVSAVASYV PGYRLKQAVQ 250
FDRYTAANPL ALHANERRAG LKVSVFLEVE GAAHYLPSYA GNLDIMTSAA 300
LAAAEQIAAS RVAA 314
Length:314
Mass (Da):32,943
Last modified:July 1, 2008 - v1
Checksum:i3A5BF970A913576E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001052 Genomic DNA. Translation: ACD15882.1.
RefSeqiWP_012432496.1. NC_010681.1.
YP_001895106.1. NC_010681.1.

Genome annotation databases

EnsemblBacteriaiACD15882; ACD15882; Bphyt_1467.
GeneIDi6282498.
KEGGibpy:Bphyt_1467.
PATRICi19212998. VBIBurPhy117947_5278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001052 Genomic DNA. Translation: ACD15882.1 .
RefSeqi WP_012432496.1. NC_010681.1.
YP_001895106.1. NC_010681.1.

3D structure databases

ProteinModelPortali B2T2S1.
SMRi B2T2S1. Positions 7-314.
ModBasei Search...

Protein-protein interaction databases

STRINGi 398527.Bphyt_1467.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD15882 ; ACD15882 ; Bphyt_1467 .
GeneIDi 6282498.
KEGGi bpy:Bphyt_1467.
PATRICi 19212998. VBIBurPhy117947_5278.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi HARHEQL.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci BPHY398527:GJEX-1480-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia phytofirmans PsJN."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
    , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17436 / PsJN.

Entry informationi

Entry nameiACDH_BURPP
AccessioniPrimary (citable) accession number: B2T2S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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