Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B2T2S1

- ACDH_BURPP

UniProt

B2T2S1 - ACDH_BURPP

Protein

Acetaldehyde dehydrogenase

Gene

Bphyt_1467

Organism
Burkholderia phytofirmans (strain DSM 17436 / PsJN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei133 – 1331Acyl-thioester intermediateUniRule annotation
    Binding sitei292 – 2921NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 184NADUniRule annotation
    Nucleotide bindingi164 – 1729NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBPHY398527:GJEX-1480-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]UniRule annotation
    Gene namesi
    Ordered Locus Names:Bphyt_1467
    OrganismiBurkholderia phytofirmans (strain DSM 17436 / PsJN)
    Taxonomic identifieri398527 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001739: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Acetaldehyde dehydrogenasePRO_0000387633Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398527.Bphyt_1467.

    Structurei

    3D structure databases

    ProteinModelPortaliB2T2S1.
    SMRiB2T2S1. Positions 7-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiHARHEQL.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2T2S1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYDKQDKQAV AIIGSGNIGT DLMIKVLRDA KHLEMGAMVG IDPASDGLAR    50
    AKRLGVATTA HGIEGLVTMP NFGAIRIAFD ATSAGAHHRH AAVLREHGVT 100
    VIDLTPAAIG PFVVPVVNLF AHLDAPNLNM VTCGGQATIP IVHAVSRVAP 150
    VRYAEIVASI ASRSAGPGTR ANIDEFTETT SKAIETVGGA ARGKAIIVLN 200
    PAEPPLMMRD TVYCLTEEEA DTDEIESSIR AMVSAVASYV PGYRLKQAVQ 250
    FDRYTAANPL ALHANERRAG LKVSVFLEVE GAAHYLPSYA GNLDIMTSAA 300
    LAAAEQIAAS RVAA 314
    Length:314
    Mass (Da):32,943
    Last modified:July 1, 2008 - v1
    Checksum:i3A5BF970A913576E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001052 Genomic DNA. Translation: ACD15882.1.
    RefSeqiWP_012432496.1. NC_010681.1.
    YP_001895106.1. NC_010681.1.

    Genome annotation databases

    EnsemblBacteriaiACD15882; ACD15882; Bphyt_1467.
    GeneIDi6282498.
    KEGGibpy:Bphyt_1467.
    PATRICi19212998. VBIBurPhy117947_5278.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001052 Genomic DNA. Translation: ACD15882.1 .
    RefSeqi WP_012432496.1. NC_010681.1.
    YP_001895106.1. NC_010681.1.

    3D structure databases

    ProteinModelPortali B2T2S1.
    SMRi B2T2S1. Positions 7-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398527.Bphyt_1467.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD15882 ; ACD15882 ; Bphyt_1467 .
    GeneIDi 6282498.
    KEGGi bpy:Bphyt_1467.
    PATRICi 19212998. VBIBurPhy117947_5278.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi HARHEQL.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci BPHY398527:GJEX-1480-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia phytofirmans PsJN."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
      , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17436 / PsJN.

    Entry informationi

    Entry nameiACDH_BURPP
    AccessioniPrimary (citable) accession number: B2T2S1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3