Skip Header

Contribute Send feedback
Read comments (?) or add your own

B2SZ66 (B2SZ66_BURPP) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase HAMAP-Rule MF_01018
Short name=ATP-PRT HAMAP-Rule MF_01018
Short name=ATP-PRTase HAMAP-Rule MF_01018
EC=2.4.2.17 HAMAP-Rule MF_01018
Gene names
Name:hisG HAMAP-Rule MF_01018
Ordered Locus Names:Bphyt_3561 EMBL ACD17951.1
OrganismBurkholderia phytofirmans (strain DSM 17436 / PsJN) [Complete proteome] [HAMAP] EMBL ACD17951.1
Taxonomic identifier398527 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia ›

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP-Rule MF_01018 SAAS SAAS024893

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01018 SAAS SAAS024893

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP-Rule MF_01018 SAAS SAAS024893

Subunit structure

Heteromultimer composed of HisG and HisZ subunits By similarity. HAMAP-Rule MF_01018 SAAS SAAS024893

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01018 SAAS SAAS024893.

Domain

Lacks the C-terminal regulatory region which is replaced by HisZ By similarity. HAMAP-Rule MF_01018

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Short subfamily. HAMAP-Rule MF_01018

Sequences

Sequence LengthMass (Da)Tools
B2SZ66 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 252C453994D69A9D

FASTA23224,541
        10         20         30         40         50         60 
MSAMPQTSSS PAVSAPLTLA LSKGRIFEET LPLLAAAGIE VAEDPETSRK LILPTTDANL 

        70         80         90        100        110        120 
RVIIVRATDV PTYVEYGAAD FGVAGKDVLL EHGGSGLYQP VDLDIARCRM SVAVAAGFDY 

       130        140        150        160        170        180 
ANAVRQGARL RVATKYVETA REHFAAKGVH VDLIKLYGSM ELAPLVGLAD AIVDLVSSGN 

       190        200        210        220        230 
TLRANNLVEV EEIMQISSRL VVNQAALKLK RAALRPILDA FERASKAGAA TA

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia phytofirmans PsJN."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17436 / PsJN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001052 Genomic DNA. Translation: ACD17951.1.
RefSeqYP_001897175.1. NC_010681.1.

3D structure databases

ProteinModelPortalB2SZ66.
ModBaseSearch...

Protein-protein interaction databases

STRING398527.Bphyt_3561.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD17951; ACD17951; Bphyt_3561.
GeneID6282202.
KEGGbpy:Bphyt_3561.
PATRIC19217705. VBIBurPhy117947_7592.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0040.
HOGENOMHOG000223248.
KOK00765.
OMAQVDIIKL.
ProtClustDBPRK01686.

Enzyme and pathway databases

BioCycBPHY398527:GJEX-3614-MONOMER.
UniPathwayUPA00031; UER00006.

Family and domain databases

HAMAPMF_01018. HisG_Short.
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR024893. ATP_PRibTrfase_HisG_short.
[Graphical view]
PANTHERPTHR21403. PTHR21403. 1 hit.
PfamPF01634. HisG. 1 hit.
[Graphical view]
TIGRFAMsTIGR00070. hisG. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2SZ66_BURPP
AccessionPrimary (citable) accession number: B2SZ66
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info