Reviewed, UniProtKB/Swiss-Prot B2SY84 (KYNB_BURPP)

Names and origin

Protein names

Recommended name:
    Kynurenine formamidase
      Short name=KFA
    EC=3.5.1.9
Alternative name(s):
    N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	Bphyt_3227

Organism

Burkholderia phytofirmans (strain DSM 17436 / PsJN) [Complete proteome] [HAMAP]

Taxonomic identifier

398527 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Kynurenine formamidase		PRO_0000362114

Sequences

	Sequence		Length	Mass (Da)
	B2SY84-1 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: C32BDA747423C06C	FASTA	212	22,802
	10 20 30 40 50 60 MPTLWDITPA VDTATPVWPG DTPVGIERVW RMEAGSPVNV ARLTLSPHTG AHTDAPLHYD 70 80 90 100 110 120 AEGVAIGEVP LDAYLGRCRV IHCIGASPVV TPQHLSGSLD DLPPRVLLRT YRNAPTAAWD 130 140 150 160 170 180 SAFCAVAPDT IDLLAARGVK LIGIDTPSLD PQESKTMDAH HRIRTHRMAI LEGIVLDDVA 190 200 210 PGDYELIALP LKLTTLDASP VRAILRALPE SQ

References

[1]

"Complete sequence of chromosome 1 of Burkholderia phytofirmans PsJN." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Nowak J., Sessitsch A., Lazarovits G., Compant S., Barka E., Tiedje J. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001052 Genomic DNA. Translation: ACD17619.1.
RefSeq	YP_001896843.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6280895.
GenomeReviews	Gene locus Bphyt_3227 in contig CP001052_GR.
KEGG	bpy:Bphyt_3227.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	WPGDTPF.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BURPP

Accession

Primary (citable) accession number: B2SY84

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	July 1, 2008
Last modified:	November 3, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)