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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Xanthomonas oryzae pv. oryzae (strain PXO99A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXORY360094:G1GBE-3560-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PXO_01874
OrganismiXanthomonas oryzae pv. oryzae (strain PXO99A)
Taxonomic identifieri360094 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001740 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913791 – 880Leucine--tRNA ligaseAdd BLAST880

Proteomic databases

PRIDEiB2SWH2

Structurei

3D structure databases

SMRiB2SWH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 56"HIGH" regionAdd BLAST11
Motifi638 – 642"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B2SWH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVEPNVYD PHQVETSAQQ FWDATRAFQV DENSEKPKFY CLSMLPYPSG
60 70 80 90 100
ALHMGHVRNY TISDVVSRYK RMTGHNVLQP MGWDAFGLPA ENAAIKNKTA
110 120 130 140 150
PAKWTYANIA HMRAQLKSLG YAIDWSREFA TCTPDYYVHE QRMFTRLMRK
160 170 180 190 200
GLAYRRNAVV NWDPIDQTVL ANEQVIDGRG WRSGAVVEKR EIPQWFLRIT
210 220 230 240 250
DYAQELLDGL DQLDGWPDSV KTMQRNWIGR SEGLEIQFDV RDTNGAALDP
260 270 280 290 300
LRVFTTRPDT LMGVTFVSIA AEHPLALHAA KSNPELAALL ETLKHGGVSE
310 320 330 340 350
AELETQEKRG MAIGLTAVHP ISGEQVPVWV ANFVLMGYGT GAVMAVPGHD
360 370 380 390 400
QRDFEFANKY GLPIVQVVKL REPRNDDEQR WDATEWRDWY TDKSRELELI
410 420 430 440 450
NSAEFDGLDF GGAFEALAER FERKGQGQRR VNYRLRDWGV SRQRYWGCPI
460 470 480 490 500
PVIYCPKCGA VPVPEDQLPV VLPENVEFAG TGSPIKTEPT WRQTTCPDCG
510 520 530 540 550
GPAERETDTF DTFMESSWYV ARYTSPNARE MVDRRANYWM PADLYVGGIE
560 570 580 590 600
HAILHLMYFR FYHKLMRDAR LVDSDEPVTN LLTQGMVIAD TFYRDADNGG
610 620 630 640 650
KDWINPADVE IQRDERGRVT GAVLIADGQP VHIGGTEKMS KSKNNGVDPQ
660 670 680 690 700
SMVAKYGADT VRLFSMFAAP PEQSLEWNEA GVDGMARFMR RLWAQVHKHV
710 720 730 740 750
GEGAAVALDV AALSAEQKAI RRKTHETIGK VSDDYGRRHS FNTAIAAVME
760 770 780 790 800
LSNALAKFDD ASDQGRAVRQ EALEAMVLLL NPITPHASHA LWQVLGRGET
810 820 830 840 850
LLENVAFPQA DVSALVRDAL TLAVQINGKL RGTIDVAADA AREQIEALAQ
860 870 880
AEPNAAKFLD GLSVRKIIIV PGKIVNIVAG
Length:880
Mass (Da):98,464
Last modified:July 1, 2008 - v1
Checksum:i1F589B7A3FC56632
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000967 Genomic DNA Translation: ACD60183.1
RefSeqiWP_012445585.1, NC_010717.2

Genome annotation databases

EnsemblBacteriaiACD60183; ACD60183; PXO_01874
GeneIDi34180798
KEGGixop:PXO_01874

Similar proteinsi

Entry informationi

Entry nameiSYL_XANOP
AccessioniPrimary (citable) accession number: B2SWH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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