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B2SWH2

- SYL_XANOP

UniProt

B2SWH2 - SYL_XANOP

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Protein

Leucine--tRNA ligase

Gene
leuS, PXO_01874
Organism
Xanthomonas oryzae pv. oryzae (strain PXO99A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXORY360094:GI45-3600-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:PXO_01874
OrganismiXanthomonas oryzae pv. oryzae (strain PXO99A)
Taxonomic identifieri360094 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001740: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880Leucine--tRNA ligaseUniRule annotationPRO_1000091379Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360094.PXO_01874.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionUniRule annotationAdd
BLAST
Motifi638 – 6425"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiYAANYIL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2SWH2-1 [UniParc]FASTAAdd to Basket

« Hide

MSTVEPNVYD PHQVETSAQQ FWDATRAFQV DENSEKPKFY CLSMLPYPSG    50
ALHMGHVRNY TISDVVSRYK RMTGHNVLQP MGWDAFGLPA ENAAIKNKTA 100
PAKWTYANIA HMRAQLKSLG YAIDWSREFA TCTPDYYVHE QRMFTRLMRK 150
GLAYRRNAVV NWDPIDQTVL ANEQVIDGRG WRSGAVVEKR EIPQWFLRIT 200
DYAQELLDGL DQLDGWPDSV KTMQRNWIGR SEGLEIQFDV RDTNGAALDP 250
LRVFTTRPDT LMGVTFVSIA AEHPLALHAA KSNPELAALL ETLKHGGVSE 300
AELETQEKRG MAIGLTAVHP ISGEQVPVWV ANFVLMGYGT GAVMAVPGHD 350
QRDFEFANKY GLPIVQVVKL REPRNDDEQR WDATEWRDWY TDKSRELELI 400
NSAEFDGLDF GGAFEALAER FERKGQGQRR VNYRLRDWGV SRQRYWGCPI 450
PVIYCPKCGA VPVPEDQLPV VLPENVEFAG TGSPIKTEPT WRQTTCPDCG 500
GPAERETDTF DTFMESSWYV ARYTSPNARE MVDRRANYWM PADLYVGGIE 550
HAILHLMYFR FYHKLMRDAR LVDSDEPVTN LLTQGMVIAD TFYRDADNGG 600
KDWINPADVE IQRDERGRVT GAVLIADGQP VHIGGTEKMS KSKNNGVDPQ 650
SMVAKYGADT VRLFSMFAAP PEQSLEWNEA GVDGMARFMR RLWAQVHKHV 700
GEGAAVALDV AALSAEQKAI RRKTHETIGK VSDDYGRRHS FNTAIAAVME 750
LSNALAKFDD ASDQGRAVRQ EALEAMVLLL NPITPHASHA LWQVLGRGET 800
LLENVAFPQA DVSALVRDAL TLAVQINGKL RGTIDVAADA AREQIEALAQ 850
AEPNAAKFLD GLSVRKIIIV PGKIVNIVAG 880
Length:880
Mass (Da):98,464
Last modified:July 1, 2008 - v1
Checksum:i1F589B7A3FC56632
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000967 Genomic DNA. Translation: ACD60183.1.
RefSeqiYP_001914715.1. NC_010717.1.

Genome annotation databases

EnsemblBacteriaiACD60183; ACD60183; PXO_01874.
GeneIDi6307119.
KEGGixop:PXO_01874.
PATRICi24126702. VBIXanOry73153_3702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000967 Genomic DNA. Translation: ACD60183.1 .
RefSeqi YP_001914715.1. NC_010717.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360094.PXO_01874.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD60183 ; ACD60183 ; PXO_01874 .
GeneIDi 6307119.
KEGGi xop:PXO_01874.
PATRICi 24126702. VBIXanOry73153_3702.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi YAANYIL.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci XORY360094:GI45-3600-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PXO99A.

Entry informationi

Entry nameiSYL_XANOP
AccessioniPrimary (citable) accession number: B2SWH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi