B2SUY3 (LLDD_XANOP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-lactate dehydrogenase [cytochrome]
EC=1.1.2.3

Gene names

Name:	lldD
Ordered Locus Names:	PXO_03463

Organism

Xanthomonas oryzae pv. oryzae (strain PXO99A) [Complete proteome] [HAMAP]

Taxonomic identifier

360094 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas › Xanthomonas oryzae › Xanthomonas oryzae pv. oryzae

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP-Rule MF_01559
Cofactor	FMN By similarity.
Sequence similarities	Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Contains 1 FMN hydroxy acid dehydrogenase domain.

Ontologies

Keywords
Ligand	FMN Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lactate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	FMN binding Inferred from electronic annotation. Source: InterPro L-lactate dehydrogenase (cytochrome) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	L-lactate dehydrogenase [cytochrome] HAMAP-Rule MF_01559		PRO_0000383454
Regions
	Domain	1 – 380	380	FMN hydroxy acid dehydrogenase
	Nucleotide binding	306 – 330	25	FMN By similarity
Sites
	Active site	275	1	Proton acceptor By similarity
	Binding site	24	1	Substrate Potential
	Binding site	106	1	FMN By similarity
	Binding site	127	1	FMN By similarity
	Binding site	129	1	Substrate By similarity
	Binding site	155	1	FMN By similarity
	Binding site	164	1	Substrate By similarity
	Binding site	251	1	FMN By similarity
	Binding site	278	1	Substrate Potential

Sequences

	Sequence		Length	Mass (Da)
	B2SUY3 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 235429AB03A06DC2	FASTA	388	41,842
	10 20 30 40 50 60 MIISAASDYR AAAQARLPPF LFHYIDGGAY AEHTLRRNVS DLADVALRQR VLRNMSDLRL 70 80 90 100 110 120 STELFGETLA MPVALGPVGL TGMYARRGEV QAARAAAARG IPFTLSTVSV CPIEEVAPAI 130 140 150 160 170 180 ERPMWFQLYV LKDRGFMRNA LERAKAAGVT TLVFTVDMPT PGARYRDAHS GMSGPNASLR 190 200 210 220 230 240 RMLQAVTHPR WAWDVGVLGK PHDLGNISAY RGNPTGLQDY IGWLGANFDP SIAWKDLEWI 250 260 270 280 290 300 REFWTGPMVI KGILDPEDAR DAVRFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVKGE 310 320 330 340 350 360 LKILADSGIR SGLDVVRMLA LGADAVLLGR AFVYALAADG QAGVENLLTL IEKEMRVAMT 370 380 LTGTHSIAQI SADALSRVTR EQANAVSP

References

[1]

"Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99A." Salzberg S.L., Sommer D.D., Schatz M.C., Phillippy A.M., Rabinowicz P.D., Tsuge S., Furutani A., Ochiai H., Delcher A.L., Kelley D., Madupu R., Puiu D., Radune D., Shumway M., Trapnell C., Aparna G., Jha G., Pandey A. , Patil P.B., Ishihara H., Meyer D.F., Szurek B., Verdier V., Koebnik R., Dow J.M., Ryan R.P., Hirata H., Tsuyumu S., Won Lee S., Seo Y.-S., Sriariyanum M., Ronald P.C., Sonti R.V., Van Sluys M.-A., Leach J.E., White F.F., Bogdanove A.J. BMC Genomics 9:204-204(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PXO99A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000967 Genomic DNA. Translation: ACD56688.1.
RefSeq	YP_001911220.1. NC_010717.1.
3D structure databases
ProteinModelPortal	B2SUY3.
ModBase	Search...
Protein-protein interaction databases
STRING	360094.PXO_03463.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACD56688; ACD56688; PXO_03463.
GeneID	6303540.
KEGG	xop:PXO_03463.
PATRIC	24119268. VBIXanOry73153_0020.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1304.
HOGENOM	HOG000217464.
KO	K00101.
OMA	EGPEMSL.
ProtClustDB	PRK11197.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_01559. L-lact_dehydr.
InterPro	IPR013785. Aldolase_TIM. IPR012133. Alpha-hydoxy_acid_DH_FMN. IPR000262. FMN-dep_DH. IPR008259. FMN_hydac_DH_AS. IPR020920. L-lactate_DHase_cyt. [Graphical view]
Pfam	PF01070. FMN_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITE	PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LLDD_XANOP

Accession

Primary (citable) accession number: B2SUY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 1, 2008
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program