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B2SM18

- HGD_XANOP

UniProt

B2SM18 - HGD_XANOP

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Protein
Homogentisate 1,2-dioxygenase
Gene
hmgA, PXO_04215
Organism
Xanthomonas oryzae pv. oryzae (strain PXO99A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate By similarity.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei287 – 2871Proton acceptor By similarity
Metal bindingi330 – 3301Iron By similarity
Metal bindingi336 – 3361Iron By similarity
Binding sitei345 – 3451homogentisate By similarity
Metal bindingi366 – 3661Iron By similarity
Binding sitei366 – 3661homogentisate By similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciXORY360094:GI45-787-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Short name:
HGDO
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hmgA
Ordered Locus Names:PXO_04215
OrganismiXanthomonas oryzae pv. oryzae (strain PXO99A)
Taxonomic identifieri360094 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001740: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Homogentisate 1,2-dioxygenaseUniRule annotation
PRO_1000119851Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi360094.PXO_04215.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiSITTECG.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2SM18-1 [UniParc]FASTAAdd to Basket

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MHNPQHYMTG FGNEFATEAV AGSLPVGQNS PQRVAHGLYA EQLSGTAFTA    50
PRGENRRSWL YRIRPAAVHG RFSLIEQSRL HNDFGGGPVP PDQMRWSPLP 100
LPATPTDFVD GLYTMAGNGS PEAMTGVAVH LYAANASMHG RFFYNADGEL 150
LLVPQLGRLR VCTELGVLEL EPQQIGVIPR GVRFRVELLD SAARGYVCEN 200
FGGLLRLPDL GPIGANGLAN PRDFETPRAA FEQRDGAFEL VAKFQGHLWR 250
ADIDHSPLDV VAWHGNYAPY RYDLRRFNTI GSISFDHPDP SIFTVLTSPS 300
DTHGTANMDF AIFPPRWLVA QHTFRPPWFH RNVASEFMGL VHGVYDAKAE 350
GFAPGGASLH NCMSGHGPDA ATFDKASQAD LTRPDVIAET MAFMFETRAV 400
LRPTQQALSA AHRQADYQQC WSGLRAAFQH PPAKNTTSVL R 441
Length:441
Mass (Da):48,542
Last modified:July 1, 2008 - v1
Checksum:i05CF74A5847A7698
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000967 Genomic DNA. Translation: ACD57434.1.
RefSeqiWP_011409528.1. NC_010717.1.
YP_001911966.1. NC_010717.1.

Genome annotation databases

EnsemblBacteriaiACD57434; ACD57434; PXO_04215.
GeneIDi6304306.
KEGGixop:PXO_04215.
PATRICi24120876. VBIXanOry73153_0817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000967 Genomic DNA. Translation: ACD57434.1 .
RefSeqi WP_011409528.1. NC_010717.1.
YP_001911966.1. NC_010717.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360094.PXO_04215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD57434 ; ACD57434 ; PXO_04215 .
GeneIDi 6304306.
KEGGi xop:PXO_04215.
PATRICi 24120876. VBIXanOry73153_0817.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi SITTECG.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci XORY360094:GI45-787-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PXO99A.

Entry informationi

Entry nameiHGD_XANOP
AccessioniPrimary (citable) accession number: B2SM18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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