Reviewed, UniProtKB/Swiss-Prot B2SM18 (HGD_XANOP)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	PXO_04215

Organism

Xanthomonas oryzae pv. oryzae (strain PXO99A) [Complete proteome] [HAMAP]

Taxonomic identifier

360094 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Homogentisate 1,2-dioxygenase HAMAP MF_00334		PRO_1000119851
Sites
	Metal binding	330	1	Iron By similarity
	Metal binding	336	1	Iron By similarity
	Metal binding	366	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2SM18-1 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 05CF74A5847A7698	FASTA	441	48,542
	10 20 30 40 50 60 MHNPQHYMTG FGNEFATEAV AGSLPVGQNS PQRVAHGLYA EQLSGTAFTA PRGENRRSWL 70 80 90 100 110 120 YRIRPAAVHG RFSLIEQSRL HNDFGGGPVP PDQMRWSPLP LPATPTDFVD GLYTMAGNGS 130 140 150 160 170 180 PEAMTGVAVH LYAANASMHG RFFYNADGEL LLVPQLGRLR VCTELGVLEL EPQQIGVIPR 190 200 210 220 230 240 GVRFRVELLD SAARGYVCEN FGGLLRLPDL GPIGANGLAN PRDFETPRAA FEQRDGAFEL 250 260 270 280 290 300 VAKFQGHLWR ADIDHSPLDV VAWHGNYAPY RYDLRRFNTI GSISFDHPDP SIFTVLTSPS 310 320 330 340 350 360 DTHGTANMDF AIFPPRWLVA QHTFRPPWFH RNVASEFMGL VHGVYDAKAE GFAPGGASLH 370 380 390 400 410 420 NCMSGHGPDA ATFDKASQAD LTRPDVIAET MAFMFETRAV LRPTQQALSA AHRQADYQQC 430 440 WSGLRAAFQH PPAKNTTSVL R

References

[1]

"Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99A." Salzberg S.L., Sommer D.D., Schatz M.C., Phillippy A.M., Rabinowicz P.D., Tsuge S., Furutani A., Ochiai H., Delcher A.L., Kelley D., Madupu R., Puiu D., Radune D., Shumway M., Trapnell C., Aparna G., Jha G., Pandey A. , Patil P.B., Ishihara H., Meyer D.F., Szurek B., Verdier V., Koebnik R., Dow J.M., Ryan R.P., Hirata H., Tsuyumu S., Won Lee S., Seo Y.-S., Sriariyanum M., Ronald P.C., Sonti R.V., Van Sluys M.-A., Leach J.E., White F.F., Bogdanove A.J. BMC Genomics 9:204-204(2008) [PubMed: 18452608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000967 Genomic DNA. Translation: ACD57434.1.
RefSeq	YP_001911966.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6304306.
GenomeReviews	Gene locus PXO_04215 in contig CP000967_GR.
KEGG	xop:PXO_04215.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HRNCMSE.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_XANOP

Accession

Primary (citable) accession number: B2SM18

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	November 3, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)