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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Xanthomonas oryzae pv. oryzae (strain PXO99A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei154May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:PXO_00695
OrganismiXanthomonas oryzae pv. oryzae (strain PXO99A)
Taxonomic identifieri360094 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001740 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003720371 – 306GTP cyclohydrolase FolE2Add BLAST306

Structurei

3D structure databases

ProteinModelPortaliB2SJL4
SMRiB2SJL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000247517
KOiK09007

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

B2SJL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATLPDVAV TEAFTLSAPL RWVGMQDIAI PVHLDAASGS GLAARASVQV
60 70 80 90 100
DLPRAELKGI HMSRLYRLLD LHLQRPLSPA MLPQLLQALI ESHADCASRA
110 120 130 140 150
ARLTLSFALM LRMPALRSEG LSGWRAYPVR IAAQCRAGRT TIQLQVEVLY
160 170 180 190 200
ASTCPCSAAL SRQLLSDAFV QQHAWCDALP LQDVAQWLQD HGSYATPHSQ
210 220 230 240 250
RSVAQVCVDL PADTQGFAIQ ELIGLCEQAL ATPVQAAVRR PDEQAFARLN
260 270 280 290 300
GANLMYVEDA ARRLRKQLAE HYATFHVAVR HLESLHAHDA VAETGSDDET

FFPAAL
Length:306
Mass (Da):33,383
Last modified:May 5, 2009 - v2
Checksum:i7F85C6A280357FCF
GO

Sequence cautioni

The sequence ACD58798 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000967 Genomic DNA Translation: ACD58798.1 Different initiation.
RefSeqiWP_011408568.1, NC_010717.2

Genome annotation databases

EnsemblBacteriaiACD58798; ACD58798; PXO_00695
GeneIDi34178181
KEGGixop:PXO_00695

Similar proteinsi

Entry informationi

Entry nameiGCH4_XANOP
AccessioniPrimary (citable) accession number: B2SJL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: April 25, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health