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B2SJL4 (GCH4_XANOP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:PXO_00695
OrganismXanthomonas oryzae pv. oryzae (strain PXO99A) [Complete proteome] [HAMAP]
Taxonomic identifier360094 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Sequence caution

The sequence ACD58798.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000372037

Sites

Site1541May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
B2SJL4 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 7F85C6A280357FCF

FASTA30633,383
        10         20         30         40         50         60 
MSATLPDVAV TEAFTLSAPL RWVGMQDIAI PVHLDAASGS GLAARASVQV DLPRAELKGI 

        70         80         90        100        110        120 
HMSRLYRLLD LHLQRPLSPA MLPQLLQALI ESHADCASRA ARLTLSFALM LRMPALRSEG 

       130        140        150        160        170        180 
LSGWRAYPVR IAAQCRAGRT TIQLQVEVLY ASTCPCSAAL SRQLLSDAFV QQHAWCDALP 

       190        200        210        220        230        240 
LQDVAQWLQD HGSYATPHSQ RSVAQVCVDL PADTQGFAIQ ELIGLCEQAL ATPVQAAVRR 

       250        260        270        280        290        300 
PDEQAFARLN GANLMYVEDA ARRLRKQLAE HYATFHVAVR HLESLHAHDA VAETGSDDET 


FFPAAL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000967 Genomic DNA. Translation: ACD58798.1. Different initiation.
RefSeqYP_001913330.1. NC_010717.1.

3D structure databases

ProteinModelPortalB2SJL4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360094.PXO_00695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD58798; ACD58798; PXO_00695.
GeneID6305695.
KEGGxop:PXO_00695.
PATRIC24123758. VBIXanOry73153_2242.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycXORY360094:GI45-2176-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_XANOP
AccessionPrimary (citable) accession number: B2SJL4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways