B2SIT6 (KMO_XANOP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9

Alternative name(s):
Kynurenine 3-hydroxylase

Gene names

Name:	kmo
Ordered Locus Names:	PXO_00760

Organism

Xanthomonas oryzae pv. oryzae (strain PXO99A) [Complete proteome] [HAMAP]

Taxonomic identifier

360094 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
Sequence caution	The sequence ACD58731.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Kynurenine 3-monooxygenase		PRO_0000361952

Sequences

	Sequence		Length	Mass (Da)
	B2SIT6 [UniParc]. Last modified February 10, 2009. Version 2. Checksum: 5FA4778CE64A75ED	FASTA	455	51,014
	10 20 30 40 50 60 MNPVSPRSLT MIGAGLAGCL LAILLSRRGW QITVYERRGD PRIKGYECGR SINLALAERG 70 80 90 100 110 120 RHALRQAGAE EVVMAKAVMM RGRMVHPLVG EPQLQRYGRD DSEVIWSIHR AALNVALLDL 130 140 150 160 170 180 AEQAGARVHF YRRLHTVDFD AGYARFIDDR DDQPHEIHFQ SLIGSDGAGS ALRAAMQRKS 190 200 210 220 230 240 PLGERTEFLD HSYKELEIPP LPGGGFRIEG NALHIWPRGR YMFIALPNDG GTFTVTLFLP 250 260 270 280 290 300 NAGEPSFATT RNGDEAFALF ARDFPDALPL IPQLKQHWEE HPPGLLGTLT LDRWHLDGRA 310 320 330 340 350 360 LLIGDAAHAM VPFHGQGMNC AFEDCVALAD QLDAHDDLAS AFAAFEAARR DDAGAIQQMA 370 380 390 400 410 420 LENYLEMRDR VDDPEFLLQR QLEQQLQARW PTRFVPHYTM VTFLRTRYSI ALARSEIQRE 430 440 450 ILVEATRGHS DLSRLDWAAL ETIVHARLEP LDGAH

References

[1]

"Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99A." Salzberg S.L., Sommer D.D., Schatz M.C., Phillippy A.M., Rabinowicz P.D., Tsuge S., Furutani A., Ochiai H., Delcher A.L., Kelley D., Madupu R., Puiu D., Radune D., Shumway M., Trapnell C., Aparna G., Jha G., Pandey A. , Patil P.B., Ishihara H., Meyer D.F., Szurek B., Verdier V., Koebnik R., Dow J.M., Ryan R.P., Hirata H., Tsuyumu S., Won Lee S., Seo Y.-S., Sriariyanum M., Ronald P.C., Sonti R.V., Van Sluys M.-A., Leach J.E., White F.F., Bogdanove A.J. BMC Genomics 9:204-204(2008) [PubMed: 18452608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PXO99A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000967 Genomic DNA. Translation: ACD58731.1. Different initiation.
RefSeq	YP_001913263.1. NC_010717.1.
3D structure databases
ProteinModelPortal	B2SIT6.
ModBase	Search...
Protein-protein interaction databases
STRING	B2SIT6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6305628.
GenomeReviews	Gene locus PXO_00760 in contig CP000967_GR.
KEGG	xop:PXO_00760.
PATRIC	24123624. VBIXanOry73153_2175.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG430104.
ProtClustDB	CLSK903475.
Family and domain databases
InterPro	IPR002938. mOase_FAD-bd. IPR003042. Rng_hydrolase-like. [Graphical view]
KO	K00486.
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_XANOP

Accession

Primary (citable) accession number: B2SIT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 24 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program