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B2SGM9

- SYL_FRATM

UniProt

B2SGM9 - SYL_FRATM

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Francisella tularensis subsp. mediasiatica (strain FSC147)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei578 – 5781ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFTUL441952:GIY0-958-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:FTM_0959
OrganismiFrancisella tularensis subsp. mediasiatica (strain FSC147)
Taxonomic identifieri441952 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001196: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Leucine--tRNA ligasePRO_1000091320Add
BLAST

Proteomic databases

PRIDEiB2SGM9.

Interactioni

Protein-protein interaction databases

STRINGi441952.FTM_0959.

Structurei

3D structure databases

ProteinModelPortaliB2SGM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionAdd
BLAST
Motifi575 – 5795"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2SGM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEYNFSDIE KSTQEYWRKN DTFKTIEDNT KEKFYCLSML PYPSGTLHMG
60 70 80 90 100
HVRNYTIGDV IARYQKMQGK NVLHPMGWDA FGLPAENAAI KHKKSPYEWT
110 120 130 140 150
KSNIAYMRSQ FDSLGFSFDW SREIATCDED YYKWEQWFFI QLYKKGLAYR
160 170 180 190 200
KNSVVNWDPV DQTVLANEQV VDGRGWRSGA LVEKKEIPQW FLKITDYADE
210 220 230 240 250
LLQDINKLDN WPEAVKTMQI NWIGKSKGLT VKFKVKDSNQ EIEVFTTRPD
260 270 280 290 300
TLMGVNYLGI APEHPLALKE AKSNSQLAEF IEECKKTSTM EADLATQEKK
310 320 330 340 350
GFKTSIKVIH PISAETIDVW VANFVLMGYG SGAVMSVPAH DQRDWEFAQK
360 370 380 390 400
YNIPLKQVIE SNDNKLKIDL EKQAFTEKGI LINSGEFDSL NFKNAYQAIK
410 420 430 440 450
KYLTEQNKGY ETTNFRIHDW GISRQRYWGC PIPMIHCDDC GAVPEKEENL
460 470 480 490 500
PVRLPTDVAL TEAGSPLKDI PEFINVACPE CGKPAKRETD TFDTFFESSW
510 520 530 540 550
YYARYTCPTA NQMLDQEANY WLPVDKYIGG IEHAIMHLLY ARFFHKLMRD
560 570 580 590 600
QGLVKSDEPF KNLLTQGMVL KDGAKMSKSK GNIVDPQELI DKYGADTVRL
610 620 630 640 650
FSMFAAPPEQ SLEWSETGVE GTNKFLRKVF NYAELNKVIF AKNITLESQK
660 670 680 690 700
LTKEDKKARF EIHSNLKQAI FDFDKSQFNT VVSACMKILN TLNNYDNLSE
710 720 730 740 750
SVKVEGFSIL LRILAPFTPH LCHYLWQQLN LGEDILHTSF PTVDNNALEK
760 770 780 790 800
DEFLLVVQIN GKLKAKLELD ASLSSNQVEE VVLADEHVKS FIDNKQVVKV
810
IYVPQKLINI VIK
Length:813
Mass (Da):93,519
Last modified:July 1, 2008 - v1
Checksum:i5AB1688851684D2E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000915 Genomic DNA. Translation: ACD30888.1.
RefSeqiWP_012429522.1. NC_010677.1.
YP_001891666.1. NC_010677.1.

Genome annotation databases

EnsemblBacteriaiACD30888; ACD30888; FTM_0959.
GeneIDi6290486.
KEGGiftm:FTM_0959.
PATRICi17956608. VBIFraTul67519_1201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000915 Genomic DNA. Translation: ACD30888.1 .
RefSeqi WP_012429522.1. NC_010677.1.
YP_001891666.1. NC_010677.1.

3D structure databases

ProteinModelPortali B2SGM9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 441952.FTM_0959.

Proteomic databases

PRIDEi B2SGM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD30888 ; ACD30888 ; FTM_0959 .
GeneIDi 6290486.
KEGGi ftm:FTM_0959.
PATRICi 17956608. VBIFraTul67519_1201.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci FTUL441952:GIY0-958-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular evolutionary consequences of niche restriction in Francisella tularensis, a facultative intracellular pathogen."
    Larsson P., Elfsmark D., Svensson K., Wikstroem P., Forsman M., Brettin T., Keim P., Johansson A.
    PLoS Pathog. 5:E1000472-E1000472(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FSC147.

Entry informationi

Entry nameiSYL_FRATM
AccessioniPrimary (citable) accession number: B2SGM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3