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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Francisella tularensis subsp. mediasiatica (strain FSC147)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciFTUL441952:G1GAQ-1591-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:FTM_1453
OrganismiFrancisella tularensis subsp. mediasiatica (strain FSC147)
Taxonomic identifieri441952 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalUniRule annotationAdd BLAST21
Transmembranei74 – 94HelicalUniRule annotationAdd BLAST21
Transmembranei95 – 115HelicalUniRule annotationAdd BLAST21
Transmembranei134 – 154HelicalUniRule annotationAdd BLAST21
Transmembranei168 – 188HelicalUniRule annotationAdd BLAST21
Transmembranei201 – 221HelicalUniRule annotationAdd BLAST21
Transmembranei240 – 260HelicalUniRule annotationAdd BLAST21
Transmembranei267 – 287HelicalUniRule annotationAdd BLAST21
Transmembranei292 – 312HelicalUniRule annotationAdd BLAST21
Transmembranei342 – 362HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000906271 – 365Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST365

Structurei

3D structure databases

SMRiB2SDR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275122
KOiK01000
OMAiLMSPLHH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

B2SDR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIYLFEWLS HYFKGLEVFS SYISVRIIMI SITSLLITLA LGRPMISWLQ
60 70 80 90 100
KMQIGQIVRD DGPQSHFSKR NTPTMGGVLI LSSVIISCLL WGDLTSIYLW
110 120 130 140 150
ILILVVIFFG AIGFFDDYLK LVLKHPKGLR AKHKFALQSI FSIVLAIVLF
160 170 180 190 200
YLLSKNGQMS LSIPFSKSLY IPMGIVIFVV LAFFIINGSS NAVNLTDGLD
210 220 230 240 250
GLAIVPVVLV AAGLGIYAYI ETNSTLANYL LFNYLGNPGL AEVAVFCAAV
260 270 280 290 300
CGSGLAFLWF NSHPAEVFMG DVGSLTLGAV LGVIAVMVRQ ELIFFIMGLL
310 320 330 340 350
FVVEALSVML QVGSYKLRNG KRIFRMAPIH HHFELKGWPE TKVVIRFWII
360
SLILFLIGLA AIKVR
Length:365
Mass (Da):40,494
Last modified:July 1, 2008 - v1
Checksum:i0F5953F99AEA41AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000915 Genomic DNA Translation: ACD31283.1
RefSeqiWP_012429785.1, NC_010677.1

Genome annotation databases

EnsemblBacteriaiACD31283; ACD31283; FTM_1453
KEGGiftm:FTM_1453

Similar proteinsi

Entry informationi

Entry nameiMRAY_FRATM
AccessioniPrimary (citable) accession number: B2SDR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: February 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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