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B2SDQ4

- SYR_FRATM

UniProt

B2SDQ4 - SYR_FRATM

Protein

Arginine--tRNA ligase

Gene

argS

Organism
Francisella tularensis subsp. mediasiatica (strain FSC147)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFTUL441952:GIY0-1431-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
    Alternative name(s):
    Arginyl-tRNA synthetaseUniRule annotation
    Short name:
    ArgRSUniRule annotation
    Gene namesi
    Name:argSUniRule annotation
    Ordered Locus Names:FTM_1437
    OrganismiFrancisella tularensis subsp. mediasiatica (strain FSC147)
    Taxonomic identifieri441952 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000001196: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 581581Arginine--tRNA ligasePRO_1000095366Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi441952.FTM_1437.

    Structurei

    3D structure databases

    ProteinModelPortaliB2SDQ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi122 – 13211"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0018.
    HOGENOMiHOG000247212.
    KOiK01887.
    OMAiMEHMGFG.
    OrthoDBiEOG6JB13C.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2SDQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIENYLSET LAKVFQKLGY VESFAKVVTS TREDVGHFQC NGAMPLAKFA    50
    KKPPLAIAEE IVEHIDAEDI FAKLEVAKPG FINITLAPKF LADTTNRFLN 100
    SNKFGVQNNL PNRKVVLDFG GPNVAKPMHV GHIRSALLGD ALQRIHRFCG 150
    DTVVSDVHLG DWGTQMGMLI EEIKLQSPQL VYFDENYTGE YPTESPVTVQ 200
    ELAEIYPRAS KRCKSDINEM EKARLATFEL QQGRRGYVAL WQHFVRISID 250
    AVKKDFDSLD VHFDLWLGES DANKFIDEMI SYFQANNFIY EDEGAWVIDT 300
    NKDGVPPLIV IKKDGGVMYG TTDLATLWQR SKDLDPDEII YVVDKRQSLH 350
    FKQVFSVAER TKVVSEKCKL KHVAFGTVNG KDGRPFKTRE GGVMHLADLI 400
    SQAKEYAKNR MPDENDDSII DQIAMATIKF GDLINNYAND YFFDLEKFAQ 450
    HEGKTGPYLL YTVVRAKSIL RKIFGDNYDI KSLAKDYKVV NAHNEYEEKL 500
    QLQLIQFPIA VQRAYENSQP HHICEYAYSL ANSFNKFYVN CPINNLDDES 550
    LKKARIALCM ATVKAMTIAS DLIGISIPER M 581
    Length:581
    Mass (Da):65,925
    Last modified:July 1, 2008 - v1
    Checksum:iCC0249E25C43EE0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000915 Genomic DNA. Translation: ACD31268.1.
    RefSeqiYP_001892047.1. NC_010677.1.

    Genome annotation databases

    EnsemblBacteriaiACD31268; ACD31268; FTM_1437.
    GeneIDi6290729.
    KEGGiftm:FTM_1437.
    PATRICi17957807. VBIFraTul67519_1783.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000915 Genomic DNA. Translation: ACD31268.1 .
    RefSeqi YP_001892047.1. NC_010677.1.

    3D structure databases

    ProteinModelPortali B2SDQ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 441952.FTM_1437.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD31268 ; ACD31268 ; FTM_1437 .
    GeneIDi 6290729.
    KEGGi ftm:FTM_1437.
    PATRICi 17957807. VBIFraTul67519_1783.

    Phylogenomic databases

    eggNOGi COG0018.
    HOGENOMi HOG000247212.
    KOi K01887.
    OMAi MEHMGFG.
    OrthoDBi EOG6JB13C.

    Enzyme and pathway databases

    BioCyci FTUL441952:GIY0-1431-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular evolutionary consequences of niche restriction in Francisella tularensis, a facultative intracellular pathogen."
      Larsson P., Elfsmark D., Svensson K., Wikstroem P., Forsman M., Brettin T., Keim P., Johansson A.
      PLoS Pathog. 5:E1000472-E1000472(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FSC147.

    Entry informationi

    Entry nameiSYR_FRATM
    AccessioniPrimary (citable) accession number: B2SDQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3