B2SC53 (MSRA_BRUA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	BAbS19_II09570

Organism

Brucella abortus (strain S19) [Complete proteome] [HAMAP]

Taxonomic identifier

430066 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP-Rule MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular_function	peptide-methionine (S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Peptide methionine sulfoxide reductase MsrA HAMAP-Rule MF_01401		PRO_1000145394
Sites
	Active site	57	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2SC53 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 64B43110667417B0	FASTA	218	24,017
	10 20 30 40 50 60 MSFFDSYRKK MQMPSKEEVL PGRVQPIPTA AAHFVSGHPL KGPWPDGMKQ VLFGMGCFWG 70 80 90 100 110 120 AERLFWQVPG VYVTAVGYAG GITPNPTYEE TCTGLTGHAE VVLVVYDPKV VTLNELLALF 130 140 150 160 170 180 WEEHDPTQGM RQGNDIGTTY RSVIYTFNAV DRAVAEKSRD AYSQALASRG LGPVTTQIAD 190 200 210 APDFYYAEDY HQQYLAKNPD GYCGLRGTGV SCPIPLAH

References

[1]

"Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes." Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W. PLoS ONE 3:E2193-E2193(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S19.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000888 Genomic DNA. Translation: ACD74440.1.
RefSeq	YP_001932886.1. NC_010740.1.
3D structure databases
ProteinModelPortal	B2SC53.
SMR	B2SC53. Positions 15-213.
ModBase	Search...
Protein-protein interaction databases
STRING	430066.BAbS19_II09570.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACD74440; ACD74440; BAbS19_II09570.
GeneID	6325900.
KEGG	bmc:BAbS19_II09570.
PATRIC	17816521. VBIBruAbo38055_1054.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HOG000263862.
KO	K07304.
OMA	QETSFEQ.
ProtClustDB	PRK00058.
Enzyme and pathway databases
BioCyc	BABO430066:GHI6-2999-MONOMER.
Family and domain databases
Gene3D	3.30.1060.10. 1 hit.
HAMAP	MF_01401. MsrA.
InterPro	IPR002569. Met_Sox_Rdtase_MsrA. [Graphical view]
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_BRUA1

Accession

Primary (citable) accession number: B2SC53

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program