SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B2SC53

- MSRA_BRUA1

UniProt

B2SC53 - MSRA_BRUA1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Peptide methionine sulfoxide reductase MsrA
Gene
msrA, BAbS19_II09570
Organism
Brucella abortus (strain S19)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei57 – 571 By similarity

GO - Molecular functioni

  1. peptide-methionine (S)-S-oxide reductase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular protein modification process Source: UniProtKB-HAMAP
  2. protein repair Source: InterPro
  3. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciBABO430066:GHI6-3001-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrA (EC:1.8.4.11)
Short name:
Protein-methionine-S-oxide reductase
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name:
Peptide Met(O) reductase
Gene namesi
Name:msrA
Ordered Locus Names:BAbS19_II09570
OrganismiBrucella abortus (strain S19)
Taxonomic identifieri430066 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002565: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Peptide methionine sulfoxide reductase MsrAUniRule annotation
PRO_1000145394Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi430066.BAbS19_II09570.

Structurei

3D structure databases

ProteinModelPortaliB2SC53.
SMRiB2SC53. Positions 15-213.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0225.
HOGENOMiHOG000263862.
KOiK07304.
OMAiWQLGDGI.
OrthoDBiEOG6091JX.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2SC53-1 [UniParc]FASTAAdd to Basket

« Hide

MSFFDSYRKK MQMPSKEEVL PGRVQPIPTA AAHFVSGHPL KGPWPDGMKQ    50
VLFGMGCFWG AERLFWQVPG VYVTAVGYAG GITPNPTYEE TCTGLTGHAE 100
VVLVVYDPKV VTLNELLALF WEEHDPTQGM RQGNDIGTTY RSVIYTFNAV 150
DRAVAEKSRD AYSQALASRG LGPVTTQIAD APDFYYAEDY HQQYLAKNPD 200
GYCGLRGTGV SCPIPLAH 218
Length:218
Mass (Da):24,017
Last modified:July 1, 2008 - v1
Checksum:i64B43110667417B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000888 Genomic DNA. Translation: ACD74440.1.
RefSeqiYP_001932886.1. NC_010740.1.

Genome annotation databases

EnsemblBacteriaiACD74440; ACD74440; BAbS19_II09570.
GeneIDi6325900.
KEGGibmc:BAbS19_II09570.
PATRICi17816521. VBIBruAbo38055_1054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000888 Genomic DNA. Translation: ACD74440.1 .
RefSeqi YP_001932886.1. NC_010740.1.

3D structure databases

ProteinModelPortali B2SC53.
SMRi B2SC53. Positions 15-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 430066.BAbS19_II09570.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD74440 ; ACD74440 ; BAbS19_II09570 .
GeneIDi 6325900.
KEGGi bmc:BAbS19_II09570.
PATRICi 17816521. VBIBruAbo38055_1054.

Phylogenomic databases

eggNOGi COG0225.
HOGENOMi HOG000263862.
KOi K07304.
OMAi WQLGDGI.
OrthoDBi EOG6091JX.

Enzyme and pathway databases

BioCyci BABO430066:GHI6-3001-MONOMER.

Family and domain databases

Gene3Di 3.30.1060.10. 1 hit.
HAMAPi MF_01401. MsrA.
InterProi IPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view ]
PANTHERi PTHR10173. PTHR10173. 1 hit.
Pfami PF01625. PMSR. 1 hit.
[Graphical view ]
SUPFAMi SSF55068. SSF55068. 1 hit.
TIGRFAMsi TIGR00401. msrA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes."
    Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W.
    PLoS ONE 3:E2193-E2193(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S19.

Entry informationi

Entry nameiMSRA_BRUA1
AccessioniPrimary (citable) accession number: B2SC53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi