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B2SC53

- MSRA_BRUA1

UniProt

B2SC53 - MSRA_BRUA1

Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Brucella abortus (strain S19)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

    Catalytic activityi

    Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
    L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei57 – 571UniRule annotation

    GO - Molecular functioni

    1. peptide-methionine (S)-S-oxide reductase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular protein modification process Source: UniProtKB-HAMAP
    2. protein repair Source: InterPro
    3. response to oxidative stress Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciBABO430066:GHI6-3001-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
    Short name:
    Protein-methionine-S-oxide reductaseUniRule annotation
    Alternative name(s):
    Peptide-methionine (S)-S-oxide reductaseUniRule annotation
    Short name:
    Peptide Met(O) reductaseUniRule annotation
    Gene namesi
    Name:msrAUniRule annotation
    Ordered Locus Names:BAbS19_II09570
    OrganismiBrucella abortus (strain S19)
    Taxonomic identifieri430066 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002565: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218Peptide methionine sulfoxide reductase MsrAPRO_1000145394Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi430066.BAbS19_II09570.

    Structurei

    3D structure databases

    ProteinModelPortaliB2SC53.
    SMRiB2SC53. Positions 15-213.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0225.
    HOGENOMiHOG000263862.
    KOiK07304.
    OMAiWQLGDGI.
    OrthoDBiEOG6091JX.

    Family and domain databases

    Gene3Di3.30.1060.10. 1 hit.
    HAMAPiMF_01401. MsrA.
    InterProiIPR028427. Met_Sox_Rdtase.
    IPR002569. Met_Sox_Rdtase_MsrA.
    [Graphical view]
    PANTHERiPTHR10173. PTHR10173. 1 hit.
    PfamiPF01625. PMSR. 1 hit.
    [Graphical view]
    SUPFAMiSSF55068. SSF55068. 1 hit.
    TIGRFAMsiTIGR00401. msrA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2SC53-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFFDSYRKK MQMPSKEEVL PGRVQPIPTA AAHFVSGHPL KGPWPDGMKQ    50
    VLFGMGCFWG AERLFWQVPG VYVTAVGYAG GITPNPTYEE TCTGLTGHAE 100
    VVLVVYDPKV VTLNELLALF WEEHDPTQGM RQGNDIGTTY RSVIYTFNAV 150
    DRAVAEKSRD AYSQALASRG LGPVTTQIAD APDFYYAEDY HQQYLAKNPD 200
    GYCGLRGTGV SCPIPLAH 218
    Length:218
    Mass (Da):24,017
    Last modified:July 1, 2008 - v1
    Checksum:i64B43110667417B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000888 Genomic DNA. Translation: ACD74440.1.
    RefSeqiYP_001932886.1. NC_010740.1.

    Genome annotation databases

    EnsemblBacteriaiACD74440; ACD74440; BAbS19_II09570.
    GeneIDi6325900.
    KEGGibmc:BAbS19_II09570.
    PATRICi17816521. VBIBruAbo38055_1054.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000888 Genomic DNA. Translation: ACD74440.1 .
    RefSeqi YP_001932886.1. NC_010740.1.

    3D structure databases

    ProteinModelPortali B2SC53.
    SMRi B2SC53. Positions 15-213.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 430066.BAbS19_II09570.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD74440 ; ACD74440 ; BAbS19_II09570 .
    GeneIDi 6325900.
    KEGGi bmc:BAbS19_II09570.
    PATRICi 17816521. VBIBruAbo38055_1054.

    Phylogenomic databases

    eggNOGi COG0225.
    HOGENOMi HOG000263862.
    KOi K07304.
    OMAi WQLGDGI.
    OrthoDBi EOG6091JX.

    Enzyme and pathway databases

    BioCyci BABO430066:GHI6-3001-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1060.10. 1 hit.
    HAMAPi MF_01401. MsrA.
    InterProi IPR028427. Met_Sox_Rdtase.
    IPR002569. Met_Sox_Rdtase_MsrA.
    [Graphical view ]
    PANTHERi PTHR10173. PTHR10173. 1 hit.
    Pfami PF01625. PMSR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55068. SSF55068. 1 hit.
    TIGRFAMsi TIGR00401. msrA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes."
      Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W.
      PLoS ONE 3:E2193-E2193(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S19.

    Entry informationi

    Entry nameiMSRA_BRUA1
    AccessioniPrimary (citable) accession number: B2SC53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3