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B2SC34 (GLK_BRUA1) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucokinase

EC=2.7.1.2
Alternative name(s):
Glucose kinase
Gene names
Name:glk
Ordered Locus Names:BAbS19_II09360
OrganismBrucella abortus (strain S19) [Complete proteome] [HAMAP]
Taxonomic identifier430066 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00524.

Sequence similarities

Belongs to the bacterial glucokinase family.

Sequence caution

The sequence AAC43672.1 differs from that shown. Reason: Erroneous initiation.

The sequence ACD74421.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glucokinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Glucokinase HAMAP-Rule MF_00524
PRO_0000383560

Regions

Nucleotide binding18 – 236ATP Potential

Sequences

Sequence LengthMass (Da)Tools
B2SC34 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: 2EBE41BFFF67FEC0

FASTA34337,073
        10         20         30         40         50         60 
MQAIIDAEQS FKFPVLVGDI GGTNARFSIL VDSNAEPKEF PVLQTADYAT IDEAIQHAIL 

        70         80         90        100        110        120 
DQTAIQPRSV ILAVAGPVDG DEIDLTNCDW VVRPKKMIAD LGFEDVTVLN DFEAQALAVV 

       130        140        150        160        170        180 
SLEGHHMEQI GGKPEEAVAT RVVLGPGTGL GVAGLFRTRH AWVPVPGEGG HIDIGPRTER 

       190        200        210        220        230        240 
DYQIFPHIER IEGRVTGEQI LSGRGLRNLY LGICAADKIT PTLETPVDIT SAGLDGSNPQ 

       250        260        270        280        290        300 
AAETLDLFAT YLGRLAGDLA LIFMAHGGVY LSGGIPVRIL SALKAGSFRA TFEDKAPHKA 

       310        320        330        340 
IMRDIPVRVI TYQLAALTGL SAFARTPSRF EVSTEGRRWR MRR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the glucokinase gene of Brucella abortus 19 and identification of three other genes."
Essenberg R.C.
J. Bacteriol. 177:6297-6300(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes."
Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W.
PLoS ONE 3:E2193-E2193(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S19.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U21919 Genomic DNA. Translation: AAC43672.1. Different initiation.
CP000888 Genomic DNA. Translation: ACD74421.1. Different initiation.
RefSeqYP_001932867.1. NC_010740.1.

3D structure databases

ProteinModelPortalB2SC34.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING430066.BAbS19_II09360.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD74421; ACD74421; BAbS19_II09360.
GeneID6325873.
KEGGbmc:BAbS19_II09360.
PATRIC17816478. VBIBruAbo38055_1034.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0837.
HOGENOMHOG000274469.
KOK00845.
OrthoDBEOG64BQ47.

Enzyme and pathway databases

BioCycBABO430066:GHI6-2980-MONOMER.

Family and domain databases

HAMAPMF_00524. Glucokinase.
InterProIPR003836. Glucokinase.
[Graphical view]
PfamPF02685. Glucokinase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00749. glk. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLK_BRUA1
AccessionPrimary (citable) accession number: B2SC34
Secondary accession number(s): Q576R6, Q59171
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families