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Protein

Glucokinase

Gene

glk

Organism
Brucella abortus (strain S19)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 236ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glucokinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO430066:GHI6-2980-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Gene namesi
Name:glk
Ordered Locus Names:BAbS19_II09360
OrganismiBrucella abortus (strain S19)
Taxonomic identifieri430066 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002565 Componenti: Chromosome 2

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343GlucokinasePRO_0000383560Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi430066.BAbS19_II09360.

Structurei

3D structure databases

ProteinModelPortaliB2SC34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial glucokinase family.Curated

Phylogenomic databases

eggNOGiCOG0837.
HOGENOMiHOG000274469.
KOiK00845.
OrthoDBiEOG64BQ47.

Family and domain databases

HAMAPiMF_00524. Glucokinase.
InterProiIPR003836. Glucokinase.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00749. glk. 1 hit.

Sequencei

Sequence statusi: Complete.

B2SC34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAIIDAEQS FKFPVLVGDI GGTNARFSIL VDSNAEPKEF PVLQTADYAT
60 70 80 90 100
IDEAIQHAIL DQTAIQPRSV ILAVAGPVDG DEIDLTNCDW VVRPKKMIAD
110 120 130 140 150
LGFEDVTVLN DFEAQALAVV SLEGHHMEQI GGKPEEAVAT RVVLGPGTGL
160 170 180 190 200
GVAGLFRTRH AWVPVPGEGG HIDIGPRTER DYQIFPHIER IEGRVTGEQI
210 220 230 240 250
LSGRGLRNLY LGICAADKIT PTLETPVDIT SAGLDGSNPQ AAETLDLFAT
260 270 280 290 300
YLGRLAGDLA LIFMAHGGVY LSGGIPVRIL SALKAGSFRA TFEDKAPHKA
310 320 330 340
IMRDIPVRVI TYQLAALTGL SAFARTPSRF EVSTEGRRWR MRR
Length:343
Mass (Da):37,073
Last modified:September 22, 2009 - v2
Checksum:i2EBE41BFFF67FEC0
GO

Sequence cautioni

The sequence AAC43672.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence ACD74421.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21919 Genomic DNA. Translation: AAC43672.1. Different initiation.
CP000888 Genomic DNA. Translation: ACD74421.1. Different initiation.
RefSeqiYP_001932867.1. NC_010740.1.

Genome annotation databases

EnsemblBacteriaiACD74421; ACD74421; BAbS19_II09360.
KEGGibmc:BAbS19_II09360.
PATRICi17816478. VBIBruAbo38055_1034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21919 Genomic DNA. Translation: AAC43672.1. Different initiation.
CP000888 Genomic DNA. Translation: ACD74421.1. Different initiation.
RefSeqiYP_001932867.1. NC_010740.1.

3D structure databases

ProteinModelPortaliB2SC34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi430066.BAbS19_II09360.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD74421; ACD74421; BAbS19_II09360.
KEGGibmc:BAbS19_II09360.
PATRICi17816478. VBIBruAbo38055_1034.

Phylogenomic databases

eggNOGiCOG0837.
HOGENOMiHOG000274469.
KOiK00845.
OrthoDBiEOG64BQ47.

Enzyme and pathway databases

BioCyciBABO430066:GHI6-2980-MONOMER.

Family and domain databases

HAMAPiMF_00524. Glucokinase.
InterProiIPR003836. Glucokinase.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00749. glk. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the glucokinase gene of Brucella abortus 19 and identification of three other genes."
    Essenberg R.C.
    J. Bacteriol. 177:6297-6300(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes."
    Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W.
    PLoS ONE 3:E2193-E2193(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S19.

Entry informationi

Entry nameiGLK_BRUA1
AccessioniPrimary (citable) accession number: B2SC34
Secondary accession number(s): Q576R6, Q59171
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: April 1, 2015
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.