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B2SC34

- GLK_BRUA1

UniProt

B2SC34 - GLK_BRUA1

Protein

Glucokinase

Gene

glk

Organism
Brucella abortus (strain S19)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 2 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-glucose = ADP + D-glucose 6-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 236ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glucokinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO430066:GHI6-2980-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucokinase (EC:2.7.1.2)
    Alternative name(s):
    Glucose kinase
    Gene namesi
    Name:glk
    Ordered Locus Names:BAbS19_II09360
    OrganismiBrucella abortus (strain S19)
    Taxonomic identifieri430066 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002565: Chromosome 2

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343GlucokinasePRO_0000383560Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi430066.BAbS19_II09360.

    Structurei

    3D structure databases

    ProteinModelPortaliB2SC34.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bacterial glucokinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0837.
    HOGENOMiHOG000274469.
    KOiK00845.
    OrthoDBiEOG64BQ47.

    Family and domain databases

    HAMAPiMF_00524. Glucokinase.
    InterProiIPR003836. Glucokinase.
    [Graphical view]
    PfamiPF02685. Glucokinase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00749. glk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2SC34-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQAIIDAEQS FKFPVLVGDI GGTNARFSIL VDSNAEPKEF PVLQTADYAT    50
    IDEAIQHAIL DQTAIQPRSV ILAVAGPVDG DEIDLTNCDW VVRPKKMIAD 100
    LGFEDVTVLN DFEAQALAVV SLEGHHMEQI GGKPEEAVAT RVVLGPGTGL 150
    GVAGLFRTRH AWVPVPGEGG HIDIGPRTER DYQIFPHIER IEGRVTGEQI 200
    LSGRGLRNLY LGICAADKIT PTLETPVDIT SAGLDGSNPQ AAETLDLFAT 250
    YLGRLAGDLA LIFMAHGGVY LSGGIPVRIL SALKAGSFRA TFEDKAPHKA 300
    IMRDIPVRVI TYQLAALTGL SAFARTPSRF EVSTEGRRWR MRR 343
    Length:343
    Mass (Da):37,073
    Last modified:September 22, 2009 - v2
    Checksum:i2EBE41BFFF67FEC0
    GO

    Sequence cautioni

    The sequence AAC43672.1 differs from that shown. Reason: Erroneous initiation.
    The sequence ACD74421.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U21919 Genomic DNA. Translation: AAC43672.1. Different initiation.
    CP000888 Genomic DNA. Translation: ACD74421.1. Different initiation.
    RefSeqiYP_001932867.1. NC_010740.1.

    Genome annotation databases

    EnsemblBacteriaiACD74421; ACD74421; BAbS19_II09360.
    GeneIDi6325873.
    KEGGibmc:BAbS19_II09360.
    PATRICi17816478. VBIBruAbo38055_1034.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U21919 Genomic DNA. Translation: AAC43672.1 . Different initiation.
    CP000888 Genomic DNA. Translation: ACD74421.1 . Different initiation.
    RefSeqi YP_001932867.1. NC_010740.1.

    3D structure databases

    ProteinModelPortali B2SC34.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 430066.BAbS19_II09360.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD74421 ; ACD74421 ; BAbS19_II09360 .
    GeneIDi 6325873.
    KEGGi bmc:BAbS19_II09360.
    PATRICi 17816478. VBIBruAbo38055_1034.

    Phylogenomic databases

    eggNOGi COG0837.
    HOGENOMi HOG000274469.
    KOi K00845.
    OrthoDBi EOG64BQ47.

    Enzyme and pathway databases

    BioCyci BABO430066:GHI6-2980-MONOMER.

    Family and domain databases

    HAMAPi MF_00524. Glucokinase.
    InterProi IPR003836. Glucokinase.
    [Graphical view ]
    Pfami PF02685. Glucokinase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00749. glk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the glucokinase gene of Brucella abortus 19 and identification of three other genes."
      Essenberg R.C.
      J. Bacteriol. 177:6297-6300(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes."
      Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W.
      PLoS ONE 3:E2193-E2193(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S19.

    Entry informationi

    Entry nameiGLK_BRUA1
    AccessioniPrimary (citable) accession number: B2SC34
    Secondary accession number(s): Q576R6, Q59171
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3