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B2SC28 (UPPP_BRUA1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:BAbS19_II09300
OrganismBrucella abortus (strain S19) [Complete proteome] [HAMAP]
Taxonomic identifier430066 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197354

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane107 – 12721Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane185 – 20521Helical; Potential
Transmembrane213 – 23321Helical; Potential
Transmembrane246 – 26621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B2SC28 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 10A3AFD1330B2CAD

FASTA26829,169
        10         20         30         40         50         60 
MDFFNLLEAA FLGLIEGLTE FIPVSSTGHL LLIGHFLGFE STGKTFEVLI QLGAILAILS 

        70         80         90        100        110        120 
VYSAKLARIA TDFPRDARTR RFVLGVLVAF LPAAVIGALA HGFIKGVLFE TPMLVCIMLI 

       130        140        150        160        170        180 
VGGFILLWVD QLNLRPRYHN VMDYPLPICL AIGFIQCLAM IPGVSRSGST IVGSLLLGAD 

       190        200        210        220        230        240 
KRSAAEFSFF LAMPTMAGAF AYDLFKSRNI LSFNDGALIV VGFIMAFISG VFVVRHLLDY 

       250        260 
VSRHGFALFG WWRLIVGSAG MAALIIWG 

« Hide

References

[1]"Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes."
Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W.
PLoS ONE 3:E2193-E2193(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S19.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000888 Genomic DNA. Translation: ACD74415.1.
RefSeqYP_001932861.1. NC_010740.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING430066.BAbS19_II09300.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD74415; ACD74415; BAbS19_II09300.
GeneID6325750.
KEGGbmc:BAbS19_II09300.
PATRIC17816464. VBIBruAbo38055_1027.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAMGASKRS.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycBABO430066:GHI6-2974-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_BRUA1
AccessionPrimary (citable) accession number: B2SC28
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families