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B2SAP7

- B2SAP7_BRUA1

UniProt

B2SAP7 - B2SAP7_BRUA1

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Brucella abortus (strain S19)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511NADPUniRule annotation
    Binding sitei150 – 1501NADPUniRule annotation
    Binding sitei180 – 1801SubstrateUniRule annotation
    Binding sitei184 – 1841SubstrateUniRule annotation
    Binding sitei218 – 2181SubstrateUniRule annotation
    Binding sitei237 – 2371SubstrateUniRule annotation
    Active sitei242 – 2421Proton acceptorUniRule annotation
    Binding sitei341 – 3411SubstrateUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolismUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBABO430066:GHI6-2479-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:BAbS19_II04350Imported
    OrganismiBrucella abortus (strain S19)Imported
    Taxonomic identifieri430066 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002565: Chromosome 2

    Interactioni

    Protein-protein interaction databases

    STRINGi430066.BAbS19_II04350.

    Structurei

    3D structure databases

    ProteinModelPortaliB2SAP7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046192.
    KOiK00036.
    OMAiDSIMEAW.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2SAP7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSQTIPVDP FDCIVFGGTG DLAERKLIPA LYQRQRAGQL SDPTRIIGAS    50
    RSQMTDDEYR TFAGNAIKEH VKPEEVDQAE VEIFLKRLHY VAVDAKSDEG 100
    WDALKTLIGK KPEKIRAFYL AVSPTLFGDI ATRLKAHGLI TRDTRIVVEK 150
    PIGRDLDSAK ALNDTLGSVF REDQIFRIDH YLGKETVQNL MALRFANALY 200
    EPLWNSAHID HVQITVAEAV GLEGRAGYYD KAGALRDMVQ NHILQLLCLV 250
    AMEPPSSIEA DAVHDEKVKV LRSLQPISTH NVEELTVRGQ YRAGASAGGP 300
    VKGYLEDLES DTSNTETFVA LKAEIANWRW AGVPFYLRTG KRLATRVSEI 350
    VVTFKPIPHS IFGESAGKVI ANQLVIRLQP DEGVKQWLMI KDPGPGGMRL 400
    RHMPLDMSFA ESFEDRNPDA YERLIMDVVR GNQTLFMRRD EVEAAWRWID 450
    PILQAWEFNS QPVQGYTAGT WGPSSSIALI ERDGRTWHES L 491
    Length:491
    Mass (Da):55,065
    Last modified:July 1, 2008 - v1
    Checksum:i9DD52902E2398ADA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000888 Genomic DNA. Translation: ACD73934.1.
    RefSeqiYP_001932380.1. NC_010740.1.

    Genome annotation databases

    EnsemblBacteriaiACD73934; ACD73934; BAbS19_II04350.
    GeneIDi6326255.
    KEGGibmc:BAbS19_II04350.
    PATRICi17815352. VBIBruAbo38055_0481.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000888 Genomic DNA. Translation: ACD73934.1 .
    RefSeqi YP_001932380.1. NC_010740.1.

    3D structure databases

    ProteinModelPortali B2SAP7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 430066.BAbS19_II04350.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD73934 ; ACD73934 ; BAbS19_II04350 .
    GeneIDi 6326255.
    KEGGi bmc:BAbS19_II04350.
    PATRICi 17815352. VBIBruAbo38055_0481.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046192.
    KOi K00036.
    OMAi DSIMEAW.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci BABO430066:GHI6-2479-MONOMER.

    Miscellaneous databases

    PROi B2SAP7.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes."
      Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W.
      PLoS ONE 3:E2193-E2193(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S19Imported.

    Entry informationi

    Entry nameiB2SAP7_BRUA1
    AccessioniPrimary (citable) accession number: B2SAP7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3