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B2SAP7

- B2SAP7_BRUA1

UniProt

B2SAP7 - B2SAP7_BRUA1

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Brucella abortus (strain S19)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511NADPUniRule annotation
Binding sitei150 – 1501NADPUniRule annotation
Binding sitei180 – 1801SubstrateUniRule annotation
Binding sitei184 – 1841SubstrateUniRule annotation
Binding sitei218 – 2181SubstrateUniRule annotation
Binding sitei237 – 2371SubstrateUniRule annotation
Active sitei242 – 2421Proton acceptorUniRule annotation
Binding sitei341 – 3411SubstrateUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciBABO430066:GHI6-2479-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:BAbS19_II04350Imported
OrganismiBrucella abortus (strain S19)Imported
Taxonomic identifieri430066 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002565: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi430066.BAbS19_II04350.

Structurei

3D structure databases

ProteinModelPortaliB2SAP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046192.
KOiK00036.
OMAiDSIMEAW.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2SAP7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSQTIPVDP FDCIVFGGTG DLAERKLIPA LYQRQRAGQL SDPTRIIGAS
60 70 80 90 100
RSQMTDDEYR TFAGNAIKEH VKPEEVDQAE VEIFLKRLHY VAVDAKSDEG
110 120 130 140 150
WDALKTLIGK KPEKIRAFYL AVSPTLFGDI ATRLKAHGLI TRDTRIVVEK
160 170 180 190 200
PIGRDLDSAK ALNDTLGSVF REDQIFRIDH YLGKETVQNL MALRFANALY
210 220 230 240 250
EPLWNSAHID HVQITVAEAV GLEGRAGYYD KAGALRDMVQ NHILQLLCLV
260 270 280 290 300
AMEPPSSIEA DAVHDEKVKV LRSLQPISTH NVEELTVRGQ YRAGASAGGP
310 320 330 340 350
VKGYLEDLES DTSNTETFVA LKAEIANWRW AGVPFYLRTG KRLATRVSEI
360 370 380 390 400
VVTFKPIPHS IFGESAGKVI ANQLVIRLQP DEGVKQWLMI KDPGPGGMRL
410 420 430 440 450
RHMPLDMSFA ESFEDRNPDA YERLIMDVVR GNQTLFMRRD EVEAAWRWID
460 470 480 490
PILQAWEFNS QPVQGYTAGT WGPSSSIALI ERDGRTWHES L
Length:491
Mass (Da):55,065
Last modified:July 1, 2008 - v1
Checksum:i9DD52902E2398ADA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000888 Genomic DNA. Translation: ACD73934.1.
RefSeqiYP_001932380.1. NC_010740.1.

Genome annotation databases

EnsemblBacteriaiACD73934; ACD73934; BAbS19_II04350.
GeneIDi6326255.
KEGGibmc:BAbS19_II04350.
PATRICi17815352. VBIBruAbo38055_0481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000888 Genomic DNA. Translation: ACD73934.1 .
RefSeqi YP_001932380.1. NC_010740.1.

3D structure databases

ProteinModelPortali B2SAP7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 430066.BAbS19_II04350.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD73934 ; ACD73934 ; BAbS19_II04350 .
GeneIDi 6326255.
KEGGi bmc:BAbS19_II04350.
PATRICi 17815352. VBIBruAbo38055_0481.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046192.
KOi K00036.
OMAi DSIMEAW.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci BABO430066:GHI6-2479-MONOMER.

Miscellaneous databases

PROi B2SAP7.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes."
    Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W.
    PLoS ONE 3:E2193-E2193(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S19Imported.

Entry informationi

Entry nameiB2SAP7_BRUA1
AccessioniPrimary (citable) accession number: B2SAP7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3