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B2S9Y5 (MTB1_BRUA1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Modification methylase BabI

Short name=M.BabI
EC=2.1.1.72
Alternative name(s):
Adenine-specific methyltransferase BabI
DNA methyltransferase CcrM
M.CcrMI ortholog
Gene names
Name:ccrM
Ordered Locus Names:BAbS19_I04800
OrganismBrucella abortus (strain S19) [Complete proteome] [HAMAP]
Taxonomic identifier430066 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. CcrM-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology. Essential for viability By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386Modification methylase BabI
PRO_0000363188

Sequences

Sequence LengthMass (Da)Tools
B2S9Y5 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 9D83AD96152CAD6C

FASTA38643,306
        10         20         30         40         50         60 
MRSQVIEYPM SLVRLAHELP IEAPRTAWLD SIIKGDCVSA LERLPDHSVD VIFADPPYNL 

        70         80         90        100        110        120 
QLGGDLHRPD QSMVSAVDDH WDQFESFQAY DAFTRAWLLA CRRVLKPNGT IWVIGSYHNI 

       130        140        150        160        170        180 
FRVGTQLQDL GFWLLNDIVW RKTNPMPNFR GRRFQNAHET LIWASREQKG KGYTFNYEAM 

       190        200        210        220        230        240 
KAANDDVQMR SDWLFPICTG SERLKDENGD KVHPTQKPEA LLARIMMASS KPGDVILDPF 

       250        260        270        280        290        300 
FGSGTTGAVA KRLGRHFVGI EREQPYIDAA TARINAVEPL GKAELTVMTG KRAEPRVAFT 

       310        320        330        340        350        360 
SVMEAGLLRP GTVLCDERRR FAAIVRADGT LTANGEAGSI HRIGARVQGF DACNGWTFWH 

       370        380 
FEENGVLKPI DALRKIIREQ MAAAGA 

« Hide

References

[1]"Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes."
Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W.
PLoS ONE 3:E2193-E2193(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S19.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000887 Genomic DNA. Translation: ACD72015.1.
RefSeqYP_001934489.1. NC_010742.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING430066.BAbS19_I04800.

Protein family/group databases

REBASE18251. M.BabS19ORF4800P.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD72015; ACD72015; BAbS19_I04800.
GeneID6327641.
KEGGbmc:BAbS19_I04800.
PATRIC17817930. VBIBruAbo38055_1741.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0863.
HOGENOMHOG000125329.
KOK13581.
OMAFWHFEDG.
OrthoDBEOG6FV84T.
ProtClustDBCLSK2518600.

Enzyme and pathway databases

BioCycBABO430066:GHI6-472-MONOMER.

Family and domain databases

InterProIPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
[Graphical view]
PfamPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSPR00508. S21N4MTFRASE.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTB1_BRUA1
AccessionPrimary (citable) accession number: B2S9Y5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 1, 2008
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families