B2S7W9 (B2S7W9_BRUA1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902
Ordered Locus Names:	BAbS19_I00630

Organism

Brucella abortus (strain S19) [Complete proteome] [HAMAP]

Taxonomic identifier

430066 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	1071 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004013
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS004013.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS004013 DNA replication HAMAP MF_01902 SAAS SAAS004013
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2S7W9 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 3F903145CBC566D0	FASTA	1,071	120,199
	10 20 30 40 50 60 MAAASNFSFL CGASHPQELV ERAHALDLSG IGIADRNTLA GVVRAHAQWK DIRKESGFRL 70 80 90 100 110 120 FIGCRLSFID GTPDMVVYPR DRAAYGQLCR LLTEGKHRAA IKGECHLEWA DLLFRARQFQ 130 140 150 160 170 180 IAVFPPDEDE PDFAARLTEI AQAAPGSVWL ALTMPHQGQD GRRAERIARF AAQAGVPLIA 190 200 210 220 230 240 TNDVLYHHPD RRPLQDVLTA TRHHTTVFAA GRLLEKNAER HLKPPHEMVR LFRDYPEAIA 250 260 270 280 290 300 ATADFVAPIT FQLDELKYAY PDEPIPPGKT AQQHLYDLVW EGAARHYGAD MIPPKVQGLI 310 320 330 340 350 360 NKELALIARL EYEPYFLTVY DIVTHAREKG ILCQGRGSAA NSVVCFCLGI TGVNPTQVDL 370 380 390 400 410 420 LFERFISAER KEPPDIDVDF EHERREEVMQ YVYDRYSRDR AAIVATVISY RSRSAIRDVG 430 440 450 460 470 480 KALGLSEDVT AALANTVWGL SGGGIDRQHI RQAGLDPDNP IIQRAVELAI TLIGFPRHLS 490 500 510 520 530 540 QHVGGFVLTR DRLDETVPIG PAAMDKRSFI EWDKDDIDEV GLMKVDVLSL GMLTCIRKAF 550 560 570 580 590 600 DLIHQHKPQL YGGEKLTLAS LPRKDKAVYD MLCKGDSLGV FQVESRAQMN MLPRLRPQEF 610 620 630 640 650 660 YDLVIEVAIV RPGPIQGDMV HPYLRRRSGQ EPCTLPSPSP QHGPANELQQ ILGKTKGVPL 670 680 690 700 710 720 FQEQAMRIAM EAAKFTPEEA NQLRRAMATF RKMGTIHTME KKMIDGMVNR GYDRTFAENC 730 740 750 760 770 780 FNQIKGFGEY GFPESHAASF AHLVYISAWL KCHHPEVFAA ALLNSQPMGF YAPAQIVRDA 790 800 810 820 830 840 REHGVTVLPV DVNFSQWDNI LEETPDVHLA LRLGFRQIDG FSKRDTELLI ADRQEPYRTI 850 860 870 880 890 900 EDMHRRLRLD RRAFTLLADA DAFGSLDIDR RAALWAVRRL PNDETLPLFR AAAASELAQE 910 920 930 940 950 960 PRTKLPEMAA SEHVIADYET TRLSLKGHPL QYLREGLAAE GVSTCRAVQE GADGRRMKVA 970 980 990 1000 1010 1020 GVVTVRQRPG SAKGVVFLTI EDETGIANIV IWPKIMKVFR REVMSARLIH IEGRIQRSLE 1030 1040 1050 1060 1070 GVVHLVAAKL QDRSAALIEM SGREAQRLIA PSQMAHHPRN VRVMPNSRDF H

References

[1]

"Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes." Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W. PLoS ONE 3:E2193-E2193(2008) [PubMed: 18478107] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000887 Genomic DNA. Translation: ACD71623.1.
RefSeq	YP_001934097.1. NC_010742.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B2S7W9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6328011.
GenomeReviews	Gene locus BAbS19_I00630 in contig CP000887_GR.
KEGG	bmc:BAbS19_I00630.
PATRIC	17816979. VBIBruAbo38055_1273.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734490.
OMA	EQPAIRL.
ProtClustDB	PRK05672.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR012340. NA-bd_OB-fold. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B2S7W9_BRUA1

Accession

Primary (citable) accession number: B2S7W9

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)