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B2S7N1

- SYL_BRUA1

UniProt

B2S7N1 - SYL_BRUA1

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Brucella abortus (strain S19)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei631 – 6311ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO430066:GHI6-1695-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BAbS19_I16960
    OrganismiBrucella abortus (strain S19)
    Taxonomic identifieri430066 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002565: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 877877Leucine--tRNA ligasePRO_1000091295Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi430066.BAbS19_I16960.

    Structurei

    3D structure databases

    ProteinModelPortaliB2S7N1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi628 – 6325"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2S7N1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAERYNPRV AEAHWQKVWE ENRTFETDNS DSREKYYVLE MFPYPSGRIH    50
    MGHVRNYAMG DVVARYKRAK GFNVLHPMGW DAFGMPAENA AMQNKVHPKE 100
    WTYQNIATMK RQLKSMGLSL DWSREFATCD VEYYHRQQML FIDLYEKGLV 150
    TRKTSKVNWD PVDNTVLANE QVVDGRGWRS GALVEQRELT QWFFKITDFS 200
    EELLAGLDTL DQWPEKVRLM QRNWIGKSEG LQVRFALAAG TAPAGFSEVE 250
    VYTTRPDTLF GAAFVAISAD HPLAKKLSEG NAALSSFIEE CHQQGTSLAA 300
    LETAEKKGFD TGIKVKHPFD DNWELPVYVA NFVLMEYGTG AVFGCPAHDQ 350
    RDLDFANKYK LKVTPVVLPK GEDAASFSIG ETAYTDDGVM INSRFLDGMT 400
    PEAAFNEVAS RLEKTDLVGR PQAVRKVQFR LRDWGISRQR YWGCPIPMIH 450
    CESCGVNPVP RADLPVKLPD DVEFDRPGNP LDRHATWRHV KCPKCGGDAR 500
    RETDTMDTFV DSSWYYTRFT APWENEPTNR KAADHWLPVD QYIGGIEHAI 550
    LHLLYSRFFT RAMKVAGHVG VDEPFKGLFT QGMVVHETYK ANGQWVSPAD 600
    IRIEEIDGKR VATMLDSGAP VEIGSIEKMS KSKKNVVDPD DIIASYGADT 650
    ARWFVLSDSP PERDVIWTEA GAEGAHRFVQ RIWRLVAEAA PALKDVAPKA 700
    GTQGEALGVS KAVHKAVKAV GDDIEKLAFN RGVARLYELV NTLSGALQQA 750
    ADGKADAEMK GALREATEML VLMTAPMMPH LAEQCLAELG GKVAGKETLV 800
    ARAPWPVFDP ALVVENEIVL PVQINGKKRG DLTIARDADQ ASIQQAVLEL 850
    DFVKAALNGG SPKKIIVVPQ RIVNVVA 877
    Length:877
    Mass (Da):97,890
    Last modified:July 1, 2008 - v1
    Checksum:iD7910B19450827B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000887 Genomic DNA. Translation: ACD73178.1.
    RefSeqiYP_001935652.1. NC_010742.1.

    Genome annotation databases

    EnsemblBacteriaiACD73178; ACD73178; BAbS19_I16960.
    GeneIDi6326792.
    KEGGibmc:BAbS19_I16960.
    PATRICi17820690. VBIBruAbo38055_3085.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000887 Genomic DNA. Translation: ACD73178.1 .
    RefSeqi YP_001935652.1. NC_010742.1.

    3D structure databases

    ProteinModelPortali B2S7N1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 430066.BAbS19_I16960.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD73178 ; ACD73178 ; BAbS19_I16960 .
    GeneIDi 6326792.
    KEGGi bmc:BAbS19_I16960.
    PATRICi 17820690. VBIBruAbo38055_3085.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BABO430066:GHI6-1695-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes."
      Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W.
      PLoS ONE 3:E2193-E2193(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S19.

    Entry informationi

    Entry nameiSYL_BRUA1
    AccessioniPrimary (citable) accession number: B2S7N1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3