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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Brucella abortus (strain S19)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:BAbS19_I12310
OrganismiBrucella abortus (strain S19)
Taxonomic identifieri430066 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002565 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001337261 – 368Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST368

Interactioni

Protein-protein interaction databases

STRINGi430066.BAbS19_I12310

Structurei

3D structure databases

ProteinModelPortaliB2S6D5
SMRiB2S6D5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8 Bacteria
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH

Family and domain databases

Gene3Di3.30.2110.101 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

B2S6D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDETTPANK NPEKAELRCG WTTGACATAA TKAALTALIT GEFPDPVGII
60 70 80 90 100
LPKGEVPYFQ LAYEGLGEGY AMAGIVKDAG DDPDVTHGAT IISTVYPAPP
110 120 130 140 150
GTGIIFRAGE GVGTVTREGL AIPPGEAAIN PVPRRMMTEI CEAICAEYGL
160 170 180 190 200
PADLVITISV PGGEEIAQKT WNPRLGIIGG ISILGTTGVV HPFSCSAWIH
210 220 230 240 250
SIHRGIDVAR AAGQKHVLGA TGSTSEDAAQ ALYNLPDFAI LDMGDFAGGV
260 270 280 290 300
LKYLREHPID RLTIAGGFAK LTKLAQGALD LHSSRSQVDK GFLWQIAERA
310 320 330 340 350
GAPAGMKERI LLANTAMEVL ELTQSIGIDI AGPIALEARQ TALKTLRGAP
360
VEVEIIVTDR KGNILARV
Length:368
Mass (Da):38,530
Last modified:July 1, 2008 - v1
Checksum:i5F3040A081BDFFDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000887 Genomic DNA Translation: ACD72732.1
RefSeqiWP_002964416.1, NC_010742.1

Genome annotation databases

EnsemblBacteriaiACD72732; ACD72732; BAbS19_I12310
KEGGibmc:BAbS19_I12310

Similar proteinsi

Entry informationi

Entry nameiCBID_BRUA1
AccessioniPrimary (citable) accession number: B2S6D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome