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B2S469 (SYR_TREPS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:TPASS_0831
OrganismTreponema pallidum subsp. pallidum (strain SS14) [Complete proteome] [HAMAP]
Taxonomic identifier455434 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 589589Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000095417

Regions

Motif132 – 14211"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
B2S469 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: FA6156A69F4568E3

FASTA58967,132
        10         20         30         40         50         60 
MQDLCEMWRH AVARVLSQLQ GPAVEPVEGA QLVMEEPPEP GMGDIAFPLF LFAKRVRRSP 

        70         80         90        100        110        120 
AQLAQQLCTL LEEDTSMCAY GTPQARGPYL NVFLNKECVA AHTLDAIFAQ GERYGHTQYL 

       130        140        150        160        170        180 
QGKRIMVEFS SPNTNKPLHV GHLRNNAIGE SLSRIIAFCG ADVFKVNIIN DRGVHICKSM 

       190        200        210        220        230        240 
CAYQKFAHGK TPAHTGIKSD RFVGDWYVQF NRYAQQYPEE AEHDVRDLLQ RWESADPHVR 

       250        260        270        280        290        300 
ALWRTMNEWA LRGIKQTYER TGISFDKLYF ESETYTKGRE EVRRGLACGV FYQMEDNSIW 

       310        320        330        340        350        360 
VDLSSLGLDK KALLRSDGTT MYITQDIGTA IFRAQDWPFD QLLYVVGNEQ NYHFKVLFFV 

       370        380        390        400        410        420 
LRLLGYPWAQ QLHHVSYGMV NLPHGRMKSR EGTVVDADDI LDRLHSAAEE EIAKKGRENA 

       430        440        450        460        470        480 
LKHAQCIAEN VAIAALHYFL LQVSPQKDMV FHPEESLSFN GNTGPYLQYM GARISSLLKK 

       490        500        510        520        530        540 
VQEDVEQKGP REVRCDPALL THEAEWELVK ALARFPACVT RAAQGHDPSV ITGYLYTLSK 

       550        560        570        580 
SFSRFYHDCP ILCEARPDYA CARLELVRAV RIVLRTAMRL VLIPFLEEM 

« Hide

References

[1]"Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays."
Matejkova P., Strouhal M., Smajs D., Norris S.J., Palzkill T., Petrosino J.F., Sodergren E., Norton J.E., Singh J., Richmond T.A., Molla M.N., Albert T.J., Weinstock G.M.
BMC Microbiol. 8:76-76(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS14.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000805 Genomic DNA. Translation: ACD71248.1.
RefSeqYP_001933827.1. NC_010741.1.
YP_008119554.1. NC_021508.1.

3D structure databases

ProteinModelPortalB2S469.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING455434.TPASS_0831.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD71248; ACD71248; TPASS_0831.
GeneID15843693.
6332947.
KEGGtpp:TPASS_0831.
PATRIC20529463. VBITrePal10923_0880.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247211.
KOK01887.
OMAMEHMGFG.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycTPAL455434:GJ9E-873-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_TREPS
AccessionPrimary (citable) accession number: B2S469
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries