B2S452 (B2S452_TREPS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thioredoxin reductase RuleBase RU003881
EC=1.8.1.9 RuleBase RU003881

Gene names

Name:	trxB EMBL ACD71231.1
Ordered Locus Names:	TPASS_0814

Organism

Treponema pallidum subsp. pallidum (strain SS14) [Complete proteome] [HAMAP]

Taxonomic identifier

455434 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH. RuleBase RU003881
Cofactor	Binds 1 FAD per subunit By similarity. RuleBase RU003881
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. RuleBase RU003880

Ontologies

Keywords
Domain	Redox-active center RuleBase RU003880
Ligand	FAD RuleBase RU003880 Flavoprotein RuleBase RU003880
Molecular function	Oxidoreductase RuleBase RU003880
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	removal of superoxide radicals Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2S452 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 2519A5BA3BB4E012	FASTA	307	32,868
	10 20 30 40 50 60 METDYDVIIV GAGAAGLSAA QYACRANLRT LVIESKAHGG QALLIDSLEN YPGYATPISG 70 80 90 100 110 120 FEYAENMKKQ AVAFGAQIAY EEVTTIGKRD SVFHITTGTG AYTAMSVILA TGAEHRKMGI 130 140 150 160 170 180 PGESEFLGRG VSYCATCDGP FFRNKHVVVI GGGDAACDES LVLSRLTDRV TMIHRRDTLR 190 200 210 220 230 240 AQKAIAERTL KNPHIAVQWN TTLEAVRGET KVSSVLLKDV KTGETRELAC DAVFFFIGMV 250 260 270 280 290 300 PITGLLPDAE KDSTGYIVTD DEMRTSVEGI FAAGDVRAKS FRQVITATSD GALAAHAAAS YIDTLQN

References

[1]

"Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays." Matejkova P., Strouhal M., Smajs D., Norris S.J., Palzkill T., Petrosino J.F., Sodergren E., Norton J.E., Singh J., Richmond T.A., Molla M.N., Albert T.J., Weinstock G.M. BMC Microbiol. 8:76-76(2008) [PubMed: 18482458] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000805 Genomic DNA. Translation: ACD71231.1.
RefSeq	YP_001933810.1. NC_010741.1.
3D structure databases
ProteinModelPortal	B2S452.
ModBase	Search...
Protein-protein interaction databases
STRING	B2S452.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6333385.
GenomeReviews	Gene locus TPASS_0814 in contig CP000805_GR.
KEGG	tpp:TPASS_0814.
PATRIC	20529421. VBITrePal10923_0859.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG669726.
OMA	GGQMLMT.
ProtClustDB	CLSK2300308.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR005982. Thioredox_Rdtase. [Graphical view]
KO	K00384.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
TIGRFAMs	TIGR01292. TRX_reduct. 1 hit.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2S452_TREPS

Accession

Primary (citable) accession number: B2S452

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)