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B2S3H7

- SYL_TREPS

UniProt

B2S3H7 - SYL_TREPS

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Treponema pallidum subsp. pallidum (strain SS14)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei637 – 6371ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTPAL455434:GJ9E-615-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:TPASS_0586
    OrganismiTreponema pallidum subsp. pallidum (strain SS14)
    Taxonomic identifieri455434 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000001202: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 878878Leucine--tRNA ligasePRO_1000199232Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi455434.TPASS_0586.

    Structurei

    3D structure databases

    ProteinModelPortaliB2S3H7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5412"HIGH" regionAdd
    BLAST
    Motifi634 – 6385"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2S3H7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGYPFRALEK KWQAYWRDKR VFCVSEDERF PPERRAYVLD MFPYPSAQGL    50
    HVGHPEGYTA TDIYCRYLRM GGYNVLHPMG FDAFGLPAEN FALKTGTHPR 100
    VSTSANCDTF RRQIQSFGFS YDWEREISTA DPEYYRWTQW LFLKLYEKGL 150
    AYEATAPINW CPSCKTGLAN EEVRDACCER CGAEVTRRGV RQWMVRITAY 200
    AERLLSDLDE LDWPESVKQM QRNWIGKSCG AEIDFPVDAP ACSVHDKLPQ 250
    TIRVYTTRAD TLFGVTYLVL APEHEAVTAL TTHAQRAAVQ AYVQRAAKKN 300
    DLERTDLAKE KTGVFTGAYV RNPINDMRIP VWVGDYVLVS YGTGAVMAVP 350
    AHDQRDWDFA TRFGLPKLTV VSADYTATVP NSNSPQGAVL QRCVSDEGFV 400
    VNSGAFNGLA SADARERIVA HLEMRGAGAR RVTYRLRDWV FSRQRYWGEP 450
    IPLVHCPSCG VVPLPESALP LLLPETADFT PTEDGQGPLA RARTWLRVPC 500
    PQCASDAVRE TNTMPQWAGS CWYYLRYMDP RNKTAFCAPE KERYWAPVAL 550
    YVGGAEHAVL HLLYARFWHK VLYDLGLVST KEPFARLVNQ GMITSYAYRR 600
    KNGALVPHDE VHTNAQGTYV HARTGEKLEC VVAKMSKALK NVVNPDDMIA 650
    AYGADACRVY EMFMGPLEAS KPWNTQGLVG VFRFLEKIWV LAGRVAAANG 700
    IPQDSRAEPP GDLHAQKKSC SMYALETLLH RTIQKVTDDT SALSFNTAIS 750
    QMMIFVNEAT RVARRMPLPS KMWEMFVKIL SPYAPHLAEE LWEMCGHTHT 800
    IAYEPWPQVD PARVAPHVCS VVVQVNGKVR DTFSVAPNAP NEELEQKARE 850
    TAGARKFLGT QQPKRVVIVP NKLVNFVL 878
    Length:878
    Mass (Da):98,991
    Last modified:July 1, 2008 - v1
    Checksum:iDCD74E2DC3652B74
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000805 Genomic DNA. Translation: ACD71006.1.
    RefSeqiYP_001933585.1. NC_010741.1.
    YP_008119324.1. NC_021508.1.

    Genome annotation databases

    EnsemblBacteriaiACD71006; ACD71006; TPASS_0586.
    GeneIDi15843447.
    6333359.
    KEGGitpp:TPASS_0586.
    PATRICi20528929. VBITrePal10923_0628.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000805 Genomic DNA. Translation: ACD71006.1 .
    RefSeqi YP_001933585.1. NC_010741.1.
    YP_008119324.1. NC_021508.1.

    3D structure databases

    ProteinModelPortali B2S3H7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 455434.TPASS_0586.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD71006 ; ACD71006 ; TPASS_0586 .
    GeneIDi 15843447.
    6333359.
    KEGGi tpp:TPASS_0586.
    PATRICi 20528929. VBITrePal10923_0628.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci TPAL455434:GJ9E-615-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays."
      Matejkova P., Strouhal M., Smajs D., Norris S.J., Palzkill T., Petrosino J.F., Sodergren E., Norton J.E., Singh J., Richmond T.A., Molla M.N., Albert T.J., Weinstock G.M.
      BMC Microbiol. 8:76-76(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS14.

    Entry informationi

    Entry nameiSYL_TREPS
    AccessioniPrimary (citable) accession number: B2S3H7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3