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B2S3H7

- SYL_TREPS

UniProt

B2S3H7 - SYL_TREPS

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Protein

Leucine--tRNA ligase

Gene
leuS, TPASS_0586
Organism
Treponema pallidum subsp. pallidum (strain SS14)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei637 – 6371ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPAL455434:GJ9E-615-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:TPASS_0586
OrganismiTreponema pallidum subsp. pallidum (strain SS14)
Taxonomic identifieri455434 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000001202: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Leucine--tRNA ligaseUniRule annotationPRO_1000199232Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi455434.TPASS_0586.

Structurei

3D structure databases

ProteinModelPortaliB2S3H7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5412"HIGH" regionUniRule annotationAdd
BLAST
Motifi634 – 6385"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2S3H7-1 [UniParc]FASTAAdd to Basket

« Hide

MGYPFRALEK KWQAYWRDKR VFCVSEDERF PPERRAYVLD MFPYPSAQGL    50
HVGHPEGYTA TDIYCRYLRM GGYNVLHPMG FDAFGLPAEN FALKTGTHPR 100
VSTSANCDTF RRQIQSFGFS YDWEREISTA DPEYYRWTQW LFLKLYEKGL 150
AYEATAPINW CPSCKTGLAN EEVRDACCER CGAEVTRRGV RQWMVRITAY 200
AERLLSDLDE LDWPESVKQM QRNWIGKSCG AEIDFPVDAP ACSVHDKLPQ 250
TIRVYTTRAD TLFGVTYLVL APEHEAVTAL TTHAQRAAVQ AYVQRAAKKN 300
DLERTDLAKE KTGVFTGAYV RNPINDMRIP VWVGDYVLVS YGTGAVMAVP 350
AHDQRDWDFA TRFGLPKLTV VSADYTATVP NSNSPQGAVL QRCVSDEGFV 400
VNSGAFNGLA SADARERIVA HLEMRGAGAR RVTYRLRDWV FSRQRYWGEP 450
IPLVHCPSCG VVPLPESALP LLLPETADFT PTEDGQGPLA RARTWLRVPC 500
PQCASDAVRE TNTMPQWAGS CWYYLRYMDP RNKTAFCAPE KERYWAPVAL 550
YVGGAEHAVL HLLYARFWHK VLYDLGLVST KEPFARLVNQ GMITSYAYRR 600
KNGALVPHDE VHTNAQGTYV HARTGEKLEC VVAKMSKALK NVVNPDDMIA 650
AYGADACRVY EMFMGPLEAS KPWNTQGLVG VFRFLEKIWV LAGRVAAANG 700
IPQDSRAEPP GDLHAQKKSC SMYALETLLH RTIQKVTDDT SALSFNTAIS 750
QMMIFVNEAT RVARRMPLPS KMWEMFVKIL SPYAPHLAEE LWEMCGHTHT 800
IAYEPWPQVD PARVAPHVCS VVVQVNGKVR DTFSVAPNAP NEELEQKARE 850
TAGARKFLGT QQPKRVVIVP NKLVNFVL 878
Length:878
Mass (Da):98,991
Last modified:July 1, 2008 - v1
Checksum:iDCD74E2DC3652B74
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000805 Genomic DNA. Translation: ACD71006.1.
RefSeqiYP_001933585.1. NC_010741.1.
YP_008119324.1. NC_021508.1.

Genome annotation databases

EnsemblBacteriaiACD71006; ACD71006; TPASS_0586.
GeneIDi15843447.
6333359.
KEGGitpp:TPASS_0586.
PATRICi20528929. VBITrePal10923_0628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000805 Genomic DNA. Translation: ACD71006.1 .
RefSeqi YP_001933585.1. NC_010741.1.
YP_008119324.1. NC_021508.1.

3D structure databases

ProteinModelPortali B2S3H7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 455434.TPASS_0586.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD71006 ; ACD71006 ; TPASS_0586 .
GeneIDi 15843447.
6333359.
KEGGi tpp:TPASS_0586.
PATRICi 20528929. VBITrePal10923_0628.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci TPAL455434:GJ9E-615-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays."
    Matejkova P., Strouhal M., Smajs D., Norris S.J., Palzkill T., Petrosino J.F., Sodergren E., Norton J.E., Singh J., Richmond T.A., Molla M.N., Albert T.J., Weinstock G.M.
    BMC Microbiol. 8:76-76(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS14.

Entry informationi

Entry nameiSYL_TREPS
AccessioniPrimary (citable) accession number: B2S3H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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