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B2S3D0

- PGK_TREPS

UniProt

B2S3D0 - PGK_TREPS

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Protein

Phosphoglycerate kinase

Gene
pgk, TPASS_0538
Organism
Treponema pallidum subsp. pallidum (strain SS14)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Substrate By similarity
Binding sitei137 – 1371Substrate By similarity
Binding sitei174 – 1741Substrate By similarity
Binding sitei225 – 2251ATP By similarity
Binding sitei316 – 3161ATP; via carbonyl oxygen By similarity
Binding sitei347 – 3471ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi376 – 3794ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPAL455434:GJ9E-565-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:TPASS_0538
OrganismiTreponema pallidum subsp. pallidum (strain SS14)
Taxonomic identifieri455434 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000001202: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Phosphoglycerate kinaseUniRule annotationPRO_1000096389Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi455434.TPASS_0538.

Structurei

3D structure databases

ProteinModelPortaliB2S3D0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate binding By similarity
Regioni60 – 634Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2S3D0-1 [UniParc]FASTAAdd to Basket

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MMLRTCKDVT MRGERVVVRV DFNVPMRDGM VQDDTRVTAA VPTLRYIIEQ    50
GPRHVVLISH LGDPTRDADK AEGNAKKDGC PFDRHAFING KHRLKPVADC 100
LAKKLGVPVH FAPSCVGQRE FIEGLPDGSV VLLENVRFHP EETSGDAKVQ 150
EQFARELAQY GDIFVNDAFG TAHREHASTV VLPRLMRRRV AGLLIEREVR 200
YLEPMVCNPK VPMVAVVGGA KVSSKIAVLE SLLRTSTALI IGGGMAYTFL 250
KAQGVGVGTS LVEDDFIDTA RMLLQKAQSG GVSVVLPVDH VCASTFCADA 300
QPVAVDDVHI PMHLMGMDVG PRTLEQYRAH LKGVSSVLWN GPVGVFEFDA 350
FAHGTRVLAQ LIAEATDAGA TSVVGGGDSI AAVSKFGLAS RMSHVSTGGG 400
ASLKLFEGKV LPGISCLET 419
Length:419
Mass (Da):44,944
Last modified:July 1, 2008 - v1
Checksum:i7A8C5CACA906342D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000805 Genomic DNA. Translation: ACD70959.1.
RefSeqiYP_001933538.1. NC_010741.1.
YP_008119278.1. NC_021508.1.

Genome annotation databases

EnsemblBacteriaiACD70959; ACD70959; TPASS_0538.
GeneIDi15843399.
6332857.
KEGGitpp:TPASS_0538.
PATRICi20528825. VBITrePal10923_0578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000805 Genomic DNA. Translation: ACD70959.1 .
RefSeqi YP_001933538.1. NC_010741.1.
YP_008119278.1. NC_021508.1.

3D structure databases

ProteinModelPortali B2S3D0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 455434.TPASS_0538.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD70959 ; ACD70959 ; TPASS_0538 .
GeneIDi 15843399.
6332857.
KEGGi tpp:TPASS_0538.
PATRICi 20528825. VBITrePal10923_0578.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227107.
KOi K00927.
OMAi AGHPVGK.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci TPAL455434:GJ9E-565-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays."
    Matejkova P., Strouhal M., Smajs D., Norris S.J., Palzkill T., Petrosino J.F., Sodergren E., Norton J.E., Singh J., Richmond T.A., Molla M.N., Albert T.J., Weinstock G.M.
    BMC Microbiol. 8:76-76(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS14.

Entry informationi

Entry nameiPGK_TREPS
AccessioniPrimary (citable) accession number: B2S3D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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