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B2S3D0

- PGK_TREPS

UniProt

B2S3D0 - PGK_TREPS

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Treponema pallidum subsp. pallidum (strain SS14)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361SubstrateUniRule annotation
    Binding sitei137 – 1371SubstrateUniRule annotation
    Binding sitei174 – 1741SubstrateUniRule annotation
    Binding sitei225 – 2251ATPUniRule annotation
    Binding sitei316 – 3161ATP; via carbonyl oxygenUniRule annotation
    Binding sitei347 – 3471ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi376 – 3794ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTPAL455434:GJ9E-565-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:TPASS_0538
    OrganismiTreponema pallidum subsp. pallidum (strain SS14)
    Taxonomic identifieri455434 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000001202: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419Phosphoglycerate kinasePRO_1000096389Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi455434.TPASS_0538.

    Structurei

    3D structure databases

    ProteinModelPortaliB2S3D0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 233Substrate bindingUniRule annotation
    Regioni60 – 634Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227107.
    KOiK00927.
    OMAiAGHPVGK.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2S3D0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMLRTCKDVT MRGERVVVRV DFNVPMRDGM VQDDTRVTAA VPTLRYIIEQ    50
    GPRHVVLISH LGDPTRDADK AEGNAKKDGC PFDRHAFING KHRLKPVADC 100
    LAKKLGVPVH FAPSCVGQRE FIEGLPDGSV VLLENVRFHP EETSGDAKVQ 150
    EQFARELAQY GDIFVNDAFG TAHREHASTV VLPRLMRRRV AGLLIEREVR 200
    YLEPMVCNPK VPMVAVVGGA KVSSKIAVLE SLLRTSTALI IGGGMAYTFL 250
    KAQGVGVGTS LVEDDFIDTA RMLLQKAQSG GVSVVLPVDH VCASTFCADA 300
    QPVAVDDVHI PMHLMGMDVG PRTLEQYRAH LKGVSSVLWN GPVGVFEFDA 350
    FAHGTRVLAQ LIAEATDAGA TSVVGGGDSI AAVSKFGLAS RMSHVSTGGG 400
    ASLKLFEGKV LPGISCLET 419
    Length:419
    Mass (Da):44,944
    Last modified:July 1, 2008 - v1
    Checksum:i7A8C5CACA906342D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000805 Genomic DNA. Translation: ACD70959.1.
    RefSeqiYP_001933538.1. NC_010741.1.
    YP_008119278.1. NC_021508.1.

    Genome annotation databases

    EnsemblBacteriaiACD70959; ACD70959; TPASS_0538.
    GeneIDi15843399.
    6332857.
    KEGGitpp:TPASS_0538.
    PATRICi20528825. VBITrePal10923_0578.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000805 Genomic DNA. Translation: ACD70959.1 .
    RefSeqi YP_001933538.1. NC_010741.1.
    YP_008119278.1. NC_021508.1.

    3D structure databases

    ProteinModelPortali B2S3D0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 455434.TPASS_0538.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD70959 ; ACD70959 ; TPASS_0538 .
    GeneIDi 15843399.
    6332857.
    KEGGi tpp:TPASS_0538.
    PATRICi 20528825. VBITrePal10923_0578.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227107.
    KOi K00927.
    OMAi AGHPVGK.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci TPAL455434:GJ9E-565-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays."
      Matejkova P., Strouhal M., Smajs D., Norris S.J., Palzkill T., Petrosino J.F., Sodergren E., Norton J.E., Singh J., Richmond T.A., Molla M.N., Albert T.J., Weinstock G.M.
      BMC Microbiol. 8:76-76(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS14.

    Entry informationi

    Entry nameiPGK_TREPS
    AccessioniPrimary (citable) accession number: B2S3D0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3